Long-term predictors of subsequent cardiovascular events with coronary artery disease and 'desirable' levels of plasma total cholesterol.

Miller, Michael; Seidler, Alexander J.; Kwiterovich, Peter O.; Pearson, Thomas A.

doi:10.1161/01.cir.86.4.1165

Cited by 120 publications

(44 citation statements)

References 45 publications

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“…PI may also have direct value in CAD patients with reduced HDL-C but normal total cholesterol levels, in whom the risk of recurrent cardiovascular events is doubled (27,28). Therefore, future studies are required to examine the effects of PI in patients with low HDL-C levels.…”

Section: Discussionmentioning

confidence: 99%

Phosphatidylinositol increases HDL-C levels in humans

Burgess¹,

Neville

Rouillard³

et al. 2005

Journal of Lipid Research

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Studies have shown that phosphatidylinositol (PI) can stimulate reverse cholesterol transport by enhancing the flux of cholesterol into HDL and by promoting the transport of high density lipoprotein-cholesterol (HDL-C) to the liver and bile. The goal of this study was to determine the safety and therapeutic value of PI after oral administration to normolipidemic human subjects. We performed a randomized 2 week study in 16 normolipidemic subjects. Subjects received either 2.8 or 5.6 g of PI, with or without food. PI was well tolerated by all subjects. PI significantly affected the levels of HDL-C and triglyceride in the plasma of subjects receiving PI with food. The lower dose showed a 13% increase in HDL-C, whereas the high dose showed an increase of 18% over the 2 week period. Both low-and highdose groups showed significant increases in plasma apolipoprotein A-I. The high dose of PI also decreased plasma triglycerides by 36% in the fed subjects. These data suggest that after only 2 weeks, PI may have a comparable therapeutic value to niacin, with negligible side effects.

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Section: Discussionmentioning

confidence: 99%

Phosphatidylinositol increases HDL-C levels in humans

Burgess¹,

Neville

Rouillard³

et al. 2005

Journal of Lipid Research

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“…Miller et al 29 demonstrated the significance of low HDL-C as risk factor on the incidence of recurrent cardiovascular events in a follow-up study of patients with angiographically proven CAD and desirable TC levels. The AFCAPS/TexCAPS study 3 showed that, in a population without a history of CAD and with normal TC and LDL-C levels, a below-average HDL-C level (0.94 mmol/L for men and 1.03 mmol/L for women) forms an important risk factor for a first major coronary event.…”

Section: Hdl Metabolism and Recurrent Cardiovascular Eventsmentioning

confidence: 99%

Apolipoprotein Concentrations During Treatment and Recurrent Coronary Artery Disease Events

Lennep

Westerveld

Lennep

et al. 2000

ATVB

141

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Abstract-The effect of untreated total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) as cardiovascular risk factors in both primary and secondary prevention has been extensively investigated. The predictive value of on-treatment lipid and apolipoprotein levels on subsequent cardiovascular events is as yet uncertain. Eight hundred forty-eight patients (675 men and 173 women) with angiographically proven coronary artery disease (CAD) who received effective statin therapy (Ն30% decrease of baseline TC) were studied. We analyzed the predictive value of on-treatment levels of TC, LDL-C, triglycerides (TG), apolipoprotein A-I (apoA-I) and apolipoprotein B (apoB) on subsequent myocardial infarction (MI) and all cause mortality. On-treatment LDL-C levels were 2.55Ϯ0.55 mmol/L and 2.58Ϯ0.62 mmol/L for men and women respectively. Age-adjusted Cox regression analysis showed that only on-treatment apoA-I was predictive for future CAD events in both men and women, whereas on-treatment HDL-C was exclusively predictive in women. On-treatment apoB levels were predictive for recurrent CAD events in the total population but not after separate analysis for men and women. On-treatment levels of TC, LDL-C, and TG did not predict subsequent events. Multivariate analysis showed that on-treatment apoA-I and apoB were the only significant predictors for future cardiovascular events. On-treatment levels of TC, LDL-C, and TG were no longer associated with increased risk of recurrent cardiovascular events in CAD patients treated to target levels, which justifies the current guidelines. However, on-treatment levels of apoB and in particular apoA-I (and HDL-C in women) were significantly predictive for MI and all-cause mortality and may therefore be more suitable for cardiovascular risk assessment in this population. (Arterioscler Thromb Vasc

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“…9 -11 Previous studies from our laboratory have shown that subjects with isolated low HDL cholesterol were neither characterized by hyperinsulinemia nor by visceral obesity. 12 Although studies have suggested that patients with isolated low HDL cholesterol syndrome may be at increased CHD risk, 9,10,13,14 it appears very difficult to increase HDL cholesterol levels in these individuals by diet, weight loss, or pharmacotherapy. 15 …”

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confidence: 99%

Effects of Endurance Exercise Training on Plasma HDL Cholesterol Levels Depend on Levels of Triglycerides

Couillard

Després

Lamarche

et al. 2001

ATVB

254

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Abstract-High density lipoprotein (HDL) cholesterol concentrations have been shown to increase with regular endurance exercise and, therefore, can contribute to a lower risk of coronary heart disease in physically active individuals compared with sedentary subjects. Although low HDL cholesterol levels are frequently observed in combination with hypertriglyceridemia, some individuals may be characterized by isolated hypoalphalipoproteinemia, ie, low HDL cholesterol levels in the absence of elevated triglyceride (TG) concentrations. The present study compared the responses of numerous lipoprotein-lipid variables to a 20-week endurance exercise training program in men categorized on the basis of baseline TG and HDL cholesterol concentrations: (1)

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Long-term predictors of subsequent cardiovascular events with coronary artery disease and 'desirable' levels of plasma total cholesterol.

Abstract: Low HDL-C (or high TC:HDL-C) is strongly predictive of subsequent cardiovascular events in subjects with CAD, despite desirable TC. As such, identification of this potentially modifiable risk factor should be actively pursued in this high-risk subgroup.

Cited by 120 publications

References 45 publications

Phosphatidylinositol increases HDL-C levels in humans

Phosphatidylinositol increases HDL-C levels in humans

Apolipoprotein Concentrations During Treatment and Recurrent Coronary Artery Disease Events

Effects of Endurance Exercise Training on Plasma HDL Cholesterol Levels Depend on Levels of Triglycerides

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