Long-term prognosis of clinical variables, coronary reserve and extent of coronary disease in patients with a first episode of unstable angina

High‐density lipoprotein cholesterol, C‐reactive protein, and prevalence and severity of coronary artery disease in 5641 consecutive patients undergoing coronary angiography

“…It is well known that higher HDL‐C levels protect from future cardiovascular events [23–25] and its therapeutic elevation is associated with plaque regression on intravascular ultrasound studies [26]. Data are less conclusive concerning its interrelationship with CAD prevalence or even severity, with some studies reporting a significant association [27–35] and others not [36–38]. Altogether, the number of patients with angiographic evaluation of CAD in these reports was much lower than in our study.…”

Neutrophil-to-lymphocyte ratio as an independent predictor of left main and/or three-vessel disease in patients with non-ST-segment elevation myocardial infarction

“…Second, the severity of CAD was assessed based on a visual interpretation of the number of diseased vessels instead of using validated scoring system including SYNTAX score or Gensini score, or evaluating for functional ischemia. Although visual assessment of lesion severity is inherently subjective and may result in over-or underestimation, the number of diseased vessels according to visual assessment has been shown to be associated with prognosis [1][2][3]. Lastly, we did not have the data regarding time from symptom onset to presentation.…”

“…Patients with acute coronary syndrome due to left main and/or three-vessel disease (LM/3VD) are at the highest risk of short-and long-term adverse cardiovascular events [1][2][3]. In contrast to the welldefined indication for an emergent coronary angiography in ST elevation myocardial infarction (STEMI) population, there is still an uncertainty regarding the optimal timing of angiography in non-ST-elevation myocardial infarction (NSTEMI) patients, and ischemiaguided strategy is an appropriate strategy for selected low-risk patients [4].…”

Predictive Value of ST-Segment Elevation in Lead aVR for Left Main and/or Three-Vessel Disease in Non-ST-Segment Elevation Myocardial Infarction

“…11 Inclusion criteria for the study were (1) a troponin level greater than the 99th percentile reference value before cardiac catheterization; (2) chest pain (or anginal equivalent) or ischemic change on the electrocardiogram (ECG) including horizontal or down-sloping ST-segment depression (ࣙ0.05 mV) or T-wave inversion (ࣙ0.1 mV) in two or more contiguous leads; and (3) absence of ST-segment elevation and new left bundle branch block on the ECG. Myocardial infarction (MI) was diagnosed according to the criteria of the European Society of Cardiology and American College of Cardiology.…”

“…[1][2][3] Early recognition of patients with LM/3VD is crucial for disease management including coronary angiogram and revascularization, as well as choice of pharmacological agents. [1][2][3] Early recognition of patients with LM/3VD is crucial for disease management including coronary angiogram and revascularization, as well as choice of pharmacological agents.…”