Long-term prognosis of early and late prosthetic valve endocarditis

Castillo, Juan Carlos; Anguita, Manuel; Torres, Francisco; Mesa, Dolores; Franco, Manuel; González, Emilio; Muñoz, Ignacio; Vallés, F

doi:10.1016/j.amjcard.2004.01.056

Cited by 43 publications

(20 citation statements)

References 13 publications

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“…These findings are consistent with previous findings of a high mortality rate of 15% to 70%, regardless of which therapy was given. [3][4][5][6][7][8][9] The best treatment strategy for patients with PVE is still debated because guidelines based on prospective randomized trials are lacking. 11,12 Antibiotics and valve surgery both play major roles in the treatment of PVE.…”

Section: Discussionmentioning

confidence: 99%

Prosthetic Valve Endocarditis in a Multicenter Registry of Chinese Patients

Hee-Hwa

Siu

Yiu

et al. 2010

Asian Cardiovasc Thorac Ann

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We evaluated the clinical outcomes of prosthetic valve endocarditis in 2 major tertiary referral centers in Hong Kong. The study population comprised 80 consecutive Chinese patients who fulfilled the modified Duke criteria for prosthetic valve endocarditis from March 2000 to June 2007. The major clinical endpoints analyzed were hospital mortality, need for valve surgery, and relapse of prosthetic endocarditis. The mean age at presentation was 56 ± 13 years, with a slight male preponderance. There were 76 (95%) patients with involvement of a mechanical prosthesis; the majority (69%) had late prosthetic endocarditis. Major hospital complications occurred in 49 (61%) patients. The overall hospital mortality was 28% (22 patients). Thirty-four (42%) patients required valve surgery during index hospitalization, of whom 5 (15%) died due to uncontrolled sepsis. Factors associated with hospital mortality were older age at presentation, Staphylococcus aureus infection, embolic events, severe heart failure, valve surgery, and any major complication. On multivariate analysis, severe heart failure was the only independent predictor of hospital death. Among the 58 hospital survivors followed up for a mean of 48 ± 31 months, 6 (10%) developed late complications related to prosthetic valve endocarditis, with 5 documented cases of relapse.

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Section: Discussionmentioning

confidence: 99%

Prosthetic Valve Endocarditis in a Multicenter Registry of Chinese Patients

Hee-Hwa

Siu

Yiu

et al. 2010

Asian Cardiovasc Thorac Ann

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“…Prosthetic valve endocarditis (PVE) remains a diagnostic challenge, with non-specific and variable clinical symptoms and cardiac conditions. Treatment options include prolonged antibiotic therapy, repair of prosthetic valve and repeat valve replacement in complicated cases [3][4][5][6]. PVE not only carries a high in-hospital mortality risk but also is associated with high long term mortality and needs close follow up.…”

Section: Introductionmentioning

confidence: 99%

Predictors of mortality in patients with prosthetic valve infective endocarditis: A nation-wide multicenter study

Elbey

Kalkan²,

Akdağ³

et al. 2013

Cardiol J

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(OR 24.5;) and high CRP (OR 1.02; 95% CI 1.00-1.03) measured on admission were independent risk associates for in-hospital mortality Conclusions: High creatinine level, poor functional status and high CRP measured on admission were independent risk associates for in-hospital mortality, whereas a NYHA class of III/IV and high CRP reflected independent risk for stroke/mortality end point. (Cardiol J 2013; 20, 3: 323-328)

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“…This property allows for significant absorption of ciprofloxacin by polyester, followed by a slow steady release. Secondly, ciprofloxacin is a broad spectrum antibiotic that provides coverage against the most common pathogens of early prosthetic valve endocarditits [7], including coagulase-negative Staphylococcus, S. aureus, Streptococcus spp., and Enterococcus. Our group is also presently working with other antimicrobial agents, such as linezolid, which could be used in a similar fashion to ciprofloxacin.…”

Section: Discussionmentioning

confidence: 99%

“…We have previously described a methodology for coating polyester with ciprofloxacin by exploiting its dye-like characteristics [5,6]. Ciprofloxacin exhibits broad-spectrum antimicrobial activity and would be an ideal agent for the prevention of prosthetic valve endocarditis given the microbiology of its causative organisms [7]. The present investigation represents the preliminary in vivo testing of a ciprofloxacin-dyed sewing cuff and evaluation of its infection-resistance and tissue incorporation.…”

Section: Introductionmentioning

confidence: 99%