Long-term prognosis of Guillain-Barré syndrome not determined by treatment options?

Wang, Ying; Lang, Wenjuan; Zhang, Yaqian; Ma, Xiaoyi; Zhou, Chunkui; Zhang, Hongliang

doi:10.18632/oncotarget.20620

Cited by 17 publications

(14 citation statements)

References 26 publications

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“…This is supported by evidence from a systematic review of randomized controlled trials showing that early administration of IVIg or PEX significantly hastened recovery from GBS, 24 whereas the evidence for corticosteroids and other agents is limited and of low quality 25 . There is little evidence for long‐term benefits from immunotherapy 26 …”

Section: Discussionmentioning

confidence: 99%

Exploring the experiences of having Guillain‐Barré Syndrome: A qualitative interview study

Akanuwe

Laparidou

Curtis

et al. 2020

Health Expectations

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Background Guillain‐Barré syndrome (GBS) is a rare inflammatory disorder affecting the peripheral nerves. Although typically there is full neurological recovery, some people continue to experience residual physical, psychological or social problems longer term. Evidence describing the experiences of people with GBS is limited. Objective We aimed to explore the experiences of people with GBS in the UK. Design We used qualitative (face‐to‐face and telephone) interviews to explore experiences of people with GBS. Audio‐recorded data were transcribed verbatim and analysed using the Framework Method supported by NVivo 11. Setting and Participants We purposively recruited a sample of 16 volunteers with a prior diagnosis of GBS of varying age, sex, ethnicity, location, marital status, time since diagnosis and length of hospital stay to maximize differences in experience. Interviewees were required to have been discharged from hospital, able to give informed consent, able to speak and understand English and currently resident in the United Kingdom. Results The key themes arising from the analysis were as follows: the importance of early diagnosis; the experiences of inpatient care; the importance of active support for recovery; the need for communication throughout the course of the illness; the need for greater awareness, knowledge and provision of information by health‐care staff; and path to achieving function. Conclusion This is the first qualitative study exploring experiences of people with GBS in the UK through their whole illness journey from onset to recovery. The findings contribute to our understanding of the experiences and support needs of people recovering from GBS.

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Section: Discussionmentioning

confidence: 99%

Exploring the experiences of having Guillain‐Barré Syndrome: A qualitative interview study

Akanuwe

Laparidou

Curtis

et al. 2020

Health Expectations

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“…There is no study showing that a second IVIG application is effective when deterioration continues in GBS (2). It has been reported in the literature that treatment options in GBS prognosis are not effective and that recovery may be due to self-limitation of the disease (23). In our study, 44 patients (86.3%) received IVIG and six patients (11.8%) underwent plasmapheresis+IVIG.…”

Section: Discussionmentioning

confidence: 64%

Factors Associated with Prognosis in Patients with Guillain-Barré Syndrome

Çetiner¹,

Seyit²,

Akdağ³

et al. 2019

tnd

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Objective: We aimed to evaluate the demographic, clinical, laboratory and electrophysiological findings of patients with inpatient Guillain-Barré syndrome in our clinics and to investigate the effect of these parameters on the prognosis of the disease. Materials and Methods: Between January 2014 and April 2018, file records of patients admitted to our clinics with the diagnosis of Guillain-Barré syndrome were retrospectively reviewed. Demographic characteristics, clinical, laboratory and electrophysiological findings of the patients at the time of admission were recorded. Patients were clinically graded according to the Hughes classification at the time of admission and on the 3 rd month after discharge. Results: In the study, 25 of the 51 patients were male (49%) and 26 were female (51%) and the mean age was 54.21±17.32 years. According to clinical and electrophysiologic diagnosis, 34 patients (66.7%) had acute inflammatory demyelinating polyradiculoneuropathy, 9 patients (17.6%) had acute motor axonal neuropathy, 6 patients (11.8%) had acute motor sensory axonal neuropathy and 2 patients (3.9%) had Miller Fisher syndrome. According to Hughes scoring on the 3 rd month after discharge, 31 patients (60.8%) had in good prognosis (Hughes score ≤2) and 20 patients (39.2%) had in poor prognosis group (Hughes score >2). In the comparison between the two groups according to clinical, demographic, and laboratory parameters, older age (≥50), high Hughes score at admission, weakness in extremities as first complaint, the presence of complications, need for mechanical ventilation and presence of gastroenteritis as a leading infection were evaluated as prognostic factors. Conclusion: The most common variant of Guillain-Barré syndrome in our study was acute inflammatory demyelinating polyradiculoneuropathy. Older age (≥50), high Hughes score at admission, weakness in extremities as the first symptom, presence of complications, need for mechanical ventilation, and presence of gastroenteritis as a precursor infection were poor prognostic factors.

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“…It was reported that by the third month, 47.1% of GBS patients are expected to have a complete recovery, while 24.3% will have poor recovery (wheelchair-bound) 40. One longitudinal study stated that the rates of GBS patients with complete recovery or minor limitations was 41% in the first month, 71% in the third, 86% in the sixth, and 92% in the twelfth 41. Residual paralysis at the second month post onset of disease was highly associated with patients of age 8–14 years (65.2%) in this setting, which is compatible with findings reported by a study conducted in Iraq 12.…”

Section: Discussionmentioning

confidence: 99%

<p>Prevalence and outcomes of Guillain-Barré syndrome among pediatrics in Saudi Arabia: a 10-year retrospective study</p>

Asiri

Altwaijri

Baarmah

et al. 2019

NDT

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Background Guillain-Barré syndrome (GBS) is a progressive acute form of paralysis most probably secondary to an immune-mediated process. GBS among Saudis has been seldom investigated, which leaves both clinicians and researchers with scarcity in knowledge. Therefore, this study aims to assess the prevalence and clinical prognosis of GBS among pediatrics admitted with acute paralysis at a large healthcare facility in Riyadh, Saudi Arabia. Methods This retrospective study reviewed patients’ medical records between 2005 and 2015. Eligible cases were children (<14 years old) admitted to the hospital complaining of acute paralysis and later diagnosed with one form or variant of GBS. Pearson’s chi-square, Fisher’s exact test, and binary logistic regression were employed to analyze the collected data. Results The prevalence of GBS was 49%. The male-to-female ratio was 1.45:1. The mean ± standard deviation age was 7±3.7 years. There were 34 (69.4%) cases with progression to maximum paralysis in ≤2 weeks, while 15 (30.6%) cases occurred beyond 2 weeks. Males (n=24, 82.8%) were more likely to endure progression to maximum paralysis in ≤2 weeks after the disease onset, compared to females (n=10, 50%), P =0.014. All cases complaining of respiratory problems exhibited a progression to maximum paralysis in ≤2 weeks, compared to those with no respiratory problems, P =0.027. Residual paralysis at 60 days post disease onset was highly associated with GBS patients of age 8–14 years (n=15, 65.2%), compared to younger patients (n=8, 30.8%), P =0.016. Patients admitted in colder seasons (n=14, 63.6%) were more likely to suffer residual paralysis too, compared to those in warmer seasons (n=9, 33.3%), P =0.035. GBS cases who complained of facial weakness (n=9, 75%) and ocular abnormalities (n=10, 71.4%) were also more likely to endure residual paralysis at 60 days post disease onset, P =0.025 and P =0.03, respectively. Conclusion Male gender could be a determinant of rapid progression to maximum paralysis, while the older age group in pediatrics is expected to endure residual paralysis at 60 days post disease onset. GBS can be accounted as a rare disease, especially in pediatrics, so confirmed cases should be investigated comprehensively for research purposes.

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Long-term prognosis of Guillain-Barré syndrome not determined by treatment options?

Cited by 17 publications

References 26 publications

Exploring the experiences of having Guillain‐Barré Syndrome: A qualitative interview study

Exploring the experiences of having Guillain‐Barré Syndrome: A qualitative interview study

Factors Associated with Prognosis in Patients with Guillain-Barré Syndrome

<p>Prevalence and outcomes of Guillain-Barré syndrome among pediatrics in Saudi Arabia: a 10-year retrospective study</p>

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Long-term prognosis of Guillain-Barré syndrome not determined by treatment options?

Cited by 17 publications

References 26 publications

Exploring the experiences of having Guillain‐Barré Syndrome: A qualitative interview study

Exploring the experiences of having Guillain‐Barré Syndrome: A qualitative interview study

Factors Associated with Prognosis in Patients with Guillain-Barré Syndrome

<p>Prevalence and outcomes of Guillain-Barr&eacute; syndrome among pediatrics in Saudi Arabia: a 10-year retrospective study</p>

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<p>Prevalence and outcomes of Guillain-Barré syndrome among pediatrics in Saudi Arabia: a 10-year retrospective study</p>