Long-term prognosis of idiopathic nephrotic syndrome in children

Özlü, Sare Gülfem; Demircin, Gülay; Tökmeci, Nazan; Yılmaz, Aysun Çaltık; Aydoğ, Özlem; Bülbül, Mehmet; Öner, Ayşe

doi:10.3109/0886022x.2015.1010940

Cited by 14 publications

(14 citation statements)

References 29 publications

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“…However, studies from Taiwan, Turkey and Nigeria with larger sample sizes showed a lower prevalence rate (about 3%-4%) of CKD. (2,8,(15)(16)(17) Hypertension, AKI and microscopic haematuria were the features of SRNS, (16)(17)(18) as well as the predictive factors for progression to CKD. (2,8,11) However, in our cohort, those features did not differ between patients with SSNS and SRNS.…”

Section: Table I Simple Cox Regression Analysis Of Potential Factorsmentioning

confidence: 99%

“…These findings were in accordance with other cohorts from Thailand, (15) Japan (22) and Iran (23) when compared to less than 50% from Europe (10) and Turkey. (16) Banh et al have reported that INS among Asians has a better outcome when compared to the European populations. (24) This high response rate in Asian patients, when compared to Western data, was possibly due to the influence of ethnic and genetic differences.…”

Section: Table I Simple Cox Regression Analysis Of Potential Factorsmentioning

confidence: 99%

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Timing and predictive factors of developing chronic kidney disease in childhood-onset idiopathic nephrotic syndrome: an Asian experience

Idris

Nasir

Ismail

et al. 2020

smedj

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Section: Table I Simple Cox Regression Analysis Of Potential Factorsmentioning

confidence: 99%

Section: Table I Simple Cox Regression Analysis Of Potential Factorsmentioning

confidence: 99%

Timing and predictive factors of developing chronic kidney disease in childhood-onset idiopathic nephrotic syndrome: an Asian experience

Idris

Nasir

Ismail

et al. 2020

smedj

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“…Histologically, most children have minimal change disease (MCD); initial sensitivity to corticosteroids is used as a prognostic tool [2, 3]. …”

Section: Introductionmentioning

confidence: 99%

Low-dose rituximab is no less effective for nephrotic syndrome measured by 12-month outcome

Maxted¹,

Dalrymple

Chisholm

et al. 2018

Pediatr Nephrol

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ObjectiveRituximab is an effective treatment for children with steroid dependent or frequently relapsing nephrotic syndrome. The optimum dosing schedule for rituximab has not been established. We hypothesized that a single low dose of 375 mg/m2 would have comparable outcomes to higher doses in reducing the frequency of relapse and time to B cell reconstitution.MethodsWe conducted a multicenter retrospective observational cohort study of children with steroid-sensitive frequently relapsing nephrotic syndrome. Data were extracted from clinical records including the dates of diagnosis, treatment, relapses, the use of concomitant immunosuppression, and lymphocyte subset profiling. Patients treated earlier received variable doses of rituximab, although typically two doses of 750 mg/m2. Later, patients received the current regimen of a single dose of 375 mg/m2. The primary outcome was an absence of clinically confirmed relapse 12 months following rituximab administration. Secondary outcomes were median time to relapse, probability of being relapse-free at 6 and 24 months and time to reconstitution of CD19+ B cells.ResultsSixty patients received 143 courses of rituximab. Seven different dosing regimen strategies were used, ranging between 375 and 750 mg/m2 per dose, with administration of 1–4 doses. There was no significant difference in event-free survival at 12 months between dosing strategies. The median time to reconstitution of B cells was not significantly different between groups.ConclusionsUse of a single low-dose regimen of rituximab in the management of frequently relapsing nephrotic syndrome does not affect the probability of relapse at 12 months or time to B cell reconstitution compared to a conventional higher dose.Electronic supplementary materialThe online version of this article (10.1007/s00467-018-4172-3) contains supplementary material, which is available to authorized users.

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“…Furthermore, persistent proteinuria which is unresponsive to therapy is an important correlate of disease progression in lupus nephritis. Additionally, it is well known that patients with resistant nephrotic syndrome, such as focal segmental glomerulosclerosis (FSGS) are at significant increased risk of progression to CKD [38]. In the CKiD cohort, Wong et al reported that patients diagnosed with a glomerular disorder causing CKD had Up/c levels that were on average 140 % higher than those in patients with CKD of nonglomerular etiology [6].…”

Section: Proteinuria In Children With Glomerular Disordersmentioning

confidence: 98%

Proteinuria and progression of pediatric chronic kidney disease: lessons from recent clinical studies

Fathallah-Shaykh

2016

Pediatr Nephrol

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Proteinuria in children with chronic kidney disease (CKD) is common and its etiology differs from that in adults. How proteinuria influences the rate of progression of CKD has been analyzed in multiple retrospective clinical studies and more recently in a few prospective ones. In this review I summarize the results, strengths and weaknesses of each of these studies. The findings of several retrospective studies in children with CKD have confirmed what we have learned from adult studies on the association between proteinuria and worsening kidney function. Larger prospective clinical studies have examined the effects of proteinuria on the rate of decline of kidney function and the risk of end-stage kidney disease. They have also considered children with glomerular and, more importantly, the more common, congenital causes of CKD. Current studies have important strengths but also a few weaknesses that limit the validity of the conclusions which can be drawn. There is still a need for large clinical trials that focus primarily on studying the influence of proteinuria on kidney function and on finding remedies that delay progression.

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Long-term prognosis of idiopathic nephrotic syndrome in children

Cited by 14 publications

References 29 publications

Timing and predictive factors of developing chronic kidney disease in childhood-onset idiopathic nephrotic syndrome: an Asian experience

Timing and predictive factors of developing chronic kidney disease in childhood-onset idiopathic nephrotic syndrome: an Asian experience

Low-dose rituximab is no less effective for nephrotic syndrome measured by 12-month outcome

Proteinuria and progression of pediatric chronic kidney disease: lessons from recent clinical studies

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