Long term prognosis of recurrent haematuria.

Miller, Patrick F.; Speirs, N I; Aparicio, S R; Lendon, M; Savage, J. M.; Postlethwaite, R J; Brocklebank, J T; Houston, I. B.; Meadow, S R

doi:10.1136/adc.60.5.420

Cited by 19 publications

(5 citation statements)

References 12 publications

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“…Hematuria co-existing with proteinuria correlated well with the severity of the morphological glomeruli alterations in symptomless proteinuria and hematuria of the school-age population [14,15]. Hisano et al reported that a renal biopsy on patients with urine abnormalities detected by urine screening revealed IgAN in 53.7% of the patients testing positive for both proteinuria and hematuria [16].…”

Section: Discussionmentioning

confidence: 97%

Hematuria and proteinuria in a mass school urine screening test

et al. 2005

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A total of 1,044 school children identified with hematuria and/or proteinuria during a mass school urine screening test were referred to pediatric nephrologists at 13 hospitals in Korea. These children had isolated hematuria (IH) (60.1%), isolated proteinuria (IP) (26.4%: transient, 19.6%; orthostatic, 4.9%; persistent, 1.9%) or combined hematuria and proteinuria (CHP) (13.5%). The patient's history, physical examination, laboratory tests, kidney ultrasound and Doppler ultrasonography were obtained. Renal biopsies were performed on 113 children who showed severe proteinuria, hypertension, abnormal renal function, family history of chronic renal disease, systemic diseases or persistent hematuria and/or proteinuria for more than 12 months. IgA nephropathy (IgAN), thin basement membrane nephropathy (TBMN), membranoproliferative glomerulonephritis (MPGN), focal segmental glomerulosclerosis (FSGS), other GN, Alport syndrome and lupus nephritis were detected. IgAN and TBMN were the most common causes in the CHP group and IH group, respectively. Abnormal findings on the renal ultrasound with or without Doppler ultrasonography were noted in 147 cases (suspected nutcracker phenomenon, 65; increased parenchymal echogenicity, 40; hydronephrosis, 15). This study showed that the use of a mass school urine screening program can detect chronic renal disease in its early stage and recommends that more attention should be paid to identifying those children with CHP and massive proteinuria. A school urine screening program can detect chronic renal disease in its early stage. When mass screening is used, the initial aggressive diagnostic procedures such as renal biopsy are not needed. In addition, a regular follow-up for those children with IH and IP is certainly warranted.

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Section: Discussionmentioning

confidence: 97%

Hematuria and proteinuria in a mass school urine screening test

et al. 2005

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“…Hematuria coexisting with proteinuria was well correlated with the severity of morphological changes of glomerular structure of kidneys in the pediatric patients with asymptomatic proteinuria and hematuria. 27,28…”

Section: Discussionmentioning

confidence: 99%

Urine screening for a sample of egyptian school students: two centers experience

El-Gamasy

Fakhreldin

2018

IJFCM

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Abbreviations: RBCs, red blood cells; CHP, combination of both hematuria and proteinuria; PSAGN, post streptococcal acute glomerulonephritis; IH, isolated hematuria; IP, isolated proteinuria; DMP, diffuse mesangial proliferation; SLE, systemic lupus erytheromatosis Ethical issues I. The research followed the tenets of the Declaration of Helsinki.II. Obtaining informed written or oral consents from the students' parents or their school managers.III. The study was carried out after approval from by the Research Ethical Committees of Tanta and Aswan Faculties of Medicine.All participants in this study were instructed to collect a sample of urine by voiding a clean catch mid stream urine specimen into a 200 ml vessel, which was sent to a laboratory of clinical pathology departments Int J Fam Commun Med. 2018;2(1):22-26 22 Abstract Background: Mass urine screening was a beneficial method to determine the prevalence of kidney disorders and to improve their sequlae. Our work was done to determine the prevalence of silent (hidden) urinary abnormal findings among primary school students in Gharbia and Aswan Governates in Egypt. Subjects and methods:Apparently 2505 healthy primary school students were included in this study. Urine screening was done by urine sampling using the urinary dipstick method.Results: Sixty six children (2.6 %) had urinary abnormalities at the first urine screening test and only thirty six (1.4%) had urinary abnormalities at the second screening. Of the children who had urinary abnormalities, eighteen (0.72%) had isolated hematuria (IH), six (0.24%) had isolated proteinuria (IP) and twelve (0.48%) had combined hematuria and proteinuria (CHP). Renal biopsy was performed on 12 children 6 [50%] with CHP, 3[25%] with IH and 3[25%] with IP. Post streptococcal acute glomerulonephritis (PSAGN) was identified in 9 (50%), hypercalciuria in 3(16.7%), urolithiasis in 3(16.7%) and undetermined cause in 3(16.7%) of the IH children. Three (50 %) of the IP children had orthostatic proteinuria and the other 3(50%) had focal segmental glomerulosclerosis. The pattern of kidney diseases in CHP children was PSAGN in 6(50%), diffuse mesangial proliferation in 3 (25%) and IgA nephropathy in 3(25%). Conclusions:Asymptomatic urinary abnormalities were reported in a few number of primary school students in Gharbia and Aswan Governates in Egypt and PSAGN was the main etiology for these urinary findings. Nine (0.36%) of studied subjects had evidence of chronic kidney disease. This study clarified the significance of comparing the cost-benefit ratio for the application of the national program of the urine screening among school children.Citation: El-Gamasy MA, Fakhreldin AR. Urine screening for a sample of egyptian school students: two centers experience. Int J Fam Commun Med. 2018;2(1):22-26.

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“…Most consider the finding to be non-specific. However, reports of large series of biopsies performed for hematuria [7][8][9][10] fail to note this positive IF finding, which would have been expected to occur randomly if it were a non-specific finding. Vascular C3 deposits have been considered to be non-specific as they have been seen in conjunction with IgA nephropathy [11,12] and hypertension-related renal disease [13,14].…”

Section: Discussionmentioning

confidence: 93%

Vascular C3 deposits on renal biopsy in pediatric patients with hematuria

Sheth

Hawkins

Brewer

2000

Pediatric Nephrology

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Isolated deposition of the third component of complement (C3) in the renal arterioles has been noted on biopsy specimens in patients with hematuria. This entity is of little known significance and reports of this finding in pediatric patients with hematuria are rare. We reviewed the clinical histories and biopsies of 17 children with hematuria and vascular C3 deposition on biopsy at Texas Children's Hospital over an 14-year period. The mean age of presentation was 10.8 (range 4.5-16.6) years with a male preponderance (71%). Family history for hematuria was positive in 6 of 17 patients (35%). Light microscopy was normal or showed only minor abnormalities. Immunofluorescence was negative for IgA and IgG in all patients. Seven patients (41.1%) were noted to have diffuse or focally thin basement membranes on electron microscopy in addition to positive C3 immunofluorescence. The mean follow-up time was 23.8 months, during which 2 of 17 patients (12%) developed worsening proteinuria. The etiopathogenesis of this condition remains unclear, but an underlying immunological process cannot be ruled out. It is possible that this condition represents a stage of an acute glomerulonephritis. Clinical follow-up of these patients is warranted, as the long-term prognosis remains unclear.

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Long term prognosis of recurrent haematuria.

Cited by 19 publications

References 12 publications

Hematuria and proteinuria in a mass school urine screening test

Hematuria and proteinuria in a mass school urine screening test

Urine screening for a sample of egyptian school students: two centers experience

Vascular C3 deposits on renal biopsy in pediatric patients with hematuria

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