Long-Term Prognostic Factors in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A 15-Year Multicenter Retrospective Study

Liao, Qian-Qian; Ren, Ya-Fei; Zhu, Ke-Wei; Qin, Dong; Mo, Yan-Ju; Cong, Shan; Wu, Juan; Wang, Chunying; Cui, Xiao-Jiao; Xu, Hong-Zhen; Guo, Lin-Zheng; Zhang, Youyan; Song, Hai-Xia; Zhang, Wei; Yang, Zhe; Tang, Yan-Feng; Li, Zhuo-Jun; Xie, Zhou-Ni; Li, Limei; Wang, Huijuan; Zhou, Meng-Meng; Wei, Fang-Ning; Chen, Peng; Shi, Yuhong

doi:10.3389/fimmu.2022.913667

Cited by 18 publications

(8 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, liver involvement was proven to be related to the disease activity and to predict poor clinical outcomes. 9 In the present case, the patient did not comply with the treatment. He presented after two years with acute heart failure with a rapidly progressive fatal outcome.…”

Section: Discussioncontrasting

confidence: 50%

Case Report: An unusual presentation of granulomatosis with polyangiitis

et al. 2023

View full text Add to dashboard Cite

Aim: We are reporting a case of an unusual presentation of granulomatosis with polyangiitis (GPA) with liver involvement. Case presentation: A 45-year-old male patient presented with erythematous plaques on the face and bilateral nasal obstruction. On physical examination, the patient had a ring-shaped squamous plaque on the face. The laboratory findings revealed an accelerated erythrocyte sedimentation rate at 100 mm/h, an elevated C-reactive protein at 66 mg/L, hyper gamma globulinemia 16 g/L and an elevated alkaline phosphatase (twice the upper normal limit). The craniofacial and thoracoabdominal computed tomography (CT) -scans showed ethmoid and maxillary sinusitis, low facial bone density, multiple mediastinal and hilar lymphadenopathy, diffuse small pulmonary nodules, and hepatomegaly. A cutaneous lesion biopsy, the nasal mucosa, and the liver showed a chronic inflammatory granulomatosis process with necrosis. Serum anti-neutrophil cytoplasmic antibody (ANCA) against PR3 was positive. The clinical, biological, radiological, and histological findings substantiated the diagnosis of GPA. The patient received systemic steroids combined with cyclophosphamide pulses on days 1, 14 and 28 and then he was lost to follow-up. Two-years later, he presented with a cardiac failure and skin ulcer in the right lower limb. A nasal endoscopic exam showed nasal septum cartilage perforation with resorption of the middle and inferior nasal concha. Two weeks later, he developed a diffuse alveolar hemorrhage and was therefore transferred to the intensive care unit but died of respiratory failure 3 days later. Conclusion: Clinicians should be aware of GPA atypical clinical manifestations.

show abstract

Section: Discussioncontrasting

confidence: 50%

Case Report: An unusual presentation of granulomatosis with polyangiitis

et al. 2023

View full text Add to dashboard Cite

show abstract

“…A calibration curve and decision curve analysis (DCA) were used to evaluate the clinical applicability of the nomogram. 17 The calibration curve was plotted through bootstrap sampling 2000 times, and it showed that the predicted values by the nomogram were in line with the actually observed values (Fig. 3A).…”

Section: Establishment and Validation Of A Predictive Modelsupporting

confidence: 59%

Prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP)

Cui,

Xie,

Zhu

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Severe community-acquired pneumonia (SCAP) is a serious respiratory inflammation disease with high morbidity and mortality. This study aimed to evaluate the prognostic value of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR) and eosinophil-to-lymphocyte ratio (ELR) in patients with SCAP. The study retrospectively included 554 patients with SCAP, and the clinical data were obtained from the electronic patient record (EMR) system. The primary outcome was in-hospital mortality, and the secondary outcomes included hospital length of stay (LOS), overall survival (OS), admission to ICU, ICU LOS, and ICU mortality. As a result, both increased NLR and BLR were significant but independent risk factors for in-hospital mortality; NLR was negatively correlated with hospital LOS while ELR was positively correlated with hospital LOS; both increased NLR and BLR were associated with reduced OS, while in-creased ELR was associated with improved OS; increased PLR, NLR, MLR, and BLR were all correlated with elevated ICU admission rates, while increased ELR was correlated with reduced ICU admission rates; ELR was positively correlated with ICU LOS; both higher NLR and BLR were associated with elevated ICU mortality. In summary, NLR and BLR were useful biomarkers for clinical outcomes in patients with SCAP.

show abstract

“…Decision curve analysis (DCA) was performed to assess the clinical applicability of the nomogram as we previously described. 30 The nomogram with MLR and ELR added high net benefits within a wide range of threshold probabilities ( Figure 8B ). Calibration curves were plotted through bootstrap sampling 2000 times.…”

Section: Resultsmentioning

confidence: 94%

Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte Ratio (MLR), and Eosinophil-to-Lymphocyte Ratio (ELR) as Biomarkers in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

Liao,

Mo,

Zhu

et al. 2024

COPD

Self Cite

View full text Add to dashboard Cite

Purpose The study comprehensively evaluated the prognostic roles of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR), and eosinophil-to-lymphocyte ratio (ELR) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Patients and Methods Six hundred and nineteen patients with AECOPD and 300 healthy volunteers were retrospectively included into the study. The clinical characteristics of the patients with AECOPD and the complete blood counts (CBCs) of the healthy volunteers were collected. The associations of PLR, NLR, MLR, BLR, and ELR with airflow limitation, hospital length of stay (LOS), C-reactive protein (CRP), and in-hospital mortality in patients with AECOPD were analyzed. Results Compared with the healthy volunteers, PLR, NLR, MLR, BLR, and ELR were all elevated in COPD patients under stable condition. PLR, NLR, MLR, and BLR were further elevated while ELR was lowered during exacerbation. In the patients with AECOPD, PLR, NLR, and MLR were positively correlated with hospital LOS as well as CRP. In contrast, ELR was negatively correlated with hospital LOS as well as CRP. Elevated PLR, NLR, and MLR were all associated with more severe airflow limitation in AECOPD. Elevated PLR, NLR, and MLR were all associated with increased in-hospital mortality while elevated ELR was associated with decreased in-hospital mortality. Binary logistic regression analysis showed that smoking history, FEV1% predicted, pneumonia, pulmonary heart disease (PHD), uric acid (UA), albumin, and MLR were significant independent predictors ofin-hospital mortality. These predictors along with ELR were used to construct a nomogram for predicting in-hospital mortality in AECOPD. The nomogram had a C-index of 0.850 (95% CI: 0.799–0.901), and the calibration curve, decision curve analysis (DCA), and clinical impact curve (CIC) further demonstrated its good predictive value and clinical applicability. Conclusion In summary, PLR, NLR, MLR, and ELR served as useful biomarkers in patients with AECOPD.

show abstract

Long-Term Prognostic Factors in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A 15-Year Multicenter Retrospective Study

Cited by 18 publications

References 38 publications

Case Report: An unusual presentation of granulomatosis with polyangiitis

Case Report: An unusual presentation of granulomatosis with polyangiitis

Prognostic value of the platelet, neutrophil, monocyte, basophil, and eosinophil to lymphocyte ratios in patients with severe community-acquired pneumonia (SCAP)

Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte Ratio (MLR), and Eosinophil-to-Lymphocyte Ratio (ELR) as Biomarkers in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

Contact Info

Product

Resources

About