Long-term prognostic impact of beta-blockers in patients with Takotsubo syndrome: Results from the RETAKO Registry

Raposeiras‐Roubín, Sergio; Núñez‐Gil, Iván J.; Jamhour, K; Abu‐Assi, Emad; Conty, D. Aritza; Vedia, Óscar; Almendro‐Delia, Manuel; Sionís, Alessandro; Martín-García, Agustín; Corbí-Pascual, Miguel; Martínez‐Sellés, Manuel; Uribarri, Aitor; Guillén, Marta; Acuña, José María García; Pais, J Lopez; Blanco, Emilia; Vicente, José; Flecha, Alejandro Sánchez Grande; Andrés, Mireia; Pérez‐Castellanos, Alberto; Alonso, Joaquín; Rosselló, Xavier; Romo, Andrés Íñiguez; Feltes, Gisela

doi:10.1016/j.repc.2022.02.010

Cited by 7 publications

(2 citation statements)

References 25 publications

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“…Due to its specific pathophysiology and the aforementioned catecholamine surge, the interest and potential usefulness of BB in this scenario would appear evident. However, while in a large registry the use of ACEI or ARBs showed enhanced survival rates at the one-year follow-up and was additionally linked to a reduced occurrence of TTS recurrence ( 8 ), the use of BB therapy did not demonstrate any survival benefit or reduction in recurrences ( 159 ). Further investigation and validation are necessary to determine the significance of these findings, considering the low recurrence rate and conflicting results observed in other studies ( 160 , 161 ).…”

Section: Discussionmentioning

confidence: 97%

Takotsubo syndrome: unravelling the enigma of the broken heart syndrome?—a narrative review

Salamanca,

Alfonso

2023

Cardiovasc Diagn Ther

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Background and Objective Takotsubo syndrome (TTS) is a condition characterized by transient ventricular regional wall motion abnormalities, without causative coronary artery disease, typically triggered by emotional or physical stress. TTS is more common in post-menopausal women, closely resembling acute coronary syndrome (ACS) in its clinical presentation, with multiple proposed underlying pathophysiological mechanisms and no evidence-based treatments. This review aims to provide a comprehensive summary of the latest research, encompassing the pathophysiology, diagnostic findings, prognosis, and treatment options for TTS patients. Methods Relevant literature from 1990 to June 2023 on TTS epidemiology, physiopathology, diagnosis, clinical manifestations, treatment, and prognosis was retrieved through PubMed research. Only English publications were included. Key Content and Findings TTS is an increasingly recognized cardiovascular disorder, a significant release of catecholamines is thought to be a key contributing element, yet its exact mechanism remains unclear. Notably, TTS poses significant short and long-term risks akin to ACS. Initial treatment should focus on ruling out ACS and providing standard care for subsequent left ventricular dysfunction and complications. Research hints at a potential role for Angiotensin-converting enzyme inhibitors and Angiotensin II receptor blockers in improving long-term prognosis in TTS patients. Conclusions Significant knowledge gaps still exist in our understanding of the pathophysiology, treatment options, and areas for improvement in diagnosing and prognosticating this intriguing condition. Further research is therefore needed.

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Section: Discussionmentioning

confidence: 97%

Takotsubo syndrome: unravelling the enigma of the broken heart syndrome?—a narrative review

Salamanca,

Alfonso

2023

Cardiovasc Diagn Ther

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“… 19 However, large-scale registries demonstrate that β-blockers might not significantly reduce the recurrence duration of TTS. 19 , 20 Furthermore, comorbid conditions, such as anxiety, must be addressed. 9 , 13 …”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Recurrent Takotsubo Cardiomyopathy Complicated by Thromboemboli

Javed,

Ashraf,

Singh

et al. 2024

Journal of Investigative Medicine High Impact Case Reports

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Takotsubo syndrome (TTS) is a transient ventricular dysfunction with apical ballooning triggered by emotional and/or physical stress. A few risk factors have been observed in patients with recurrent TTS, for example, excessive sympathetic stimuli, medications, stress, and tumors. Clinical features can vary from chest pain to overt hemodynamic instability. Diagnosis requires both electrocardiographic features and invasive imaging such as angiography to rule out other causes of cardiomyopathy prior to diagnosis. In addition, renal infarcts presenting as a complication of TTS are relatively uncommon. In this case report, we discuss the case of a 61-year-old African American woman with a prior history of TTS being managed for abdominal pain who developed a recurrence of the TTS during the hospital course. Prompt diagnosis and management of the condition is crucial to improve outcomes especially in patients with thromboembolic phenomenon or hemodynamic instability. Further large-scale studies are warranted to determine outcomes of patients with recurrent Takotsubo cardiomyopathy with thromboembolic phenomenon.

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Effect of β-Blocker Use on Long-Term Mortality in Takotsubo Cardiomyopathy: A Systematic Review and Meta-Analysis

Ahsan¹,

Ahmad²,

Dvalishvili³

et al. 2023

The American Journal of Cardiology

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Long-term prognostic impact of beta-blockers in patients with Takotsubo syndrome: Results from the RETAKO Registry

Cited by 7 publications

References 25 publications

Takotsubo syndrome: unravelling the enigma of the broken heart syndrome?—a narrative review

Takotsubo syndrome: unravelling the enigma of the broken heart syndrome?—a narrative review

A Rare Case of Recurrent Takotsubo Cardiomyopathy Complicated by Thromboemboli

Effect of β-Blocker Use on Long-Term Mortality in Takotsubo Cardiomyopathy: A Systematic Review and Meta-Analysis

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