Long-term prognostic value of elevated heart rate one year after heart transplantation

Castel, María Ángeles; Roig, Eulàlia; Ríos, José; Tomàs, Carles; Mirabet, Sònia; Cardona, Montserrat; Brossa, Vicens; López, Laura; Vargas, Luis; Sionís, Alessandro; Vallejos, I.; Pérez‐Villa, Félix

doi:10.1016/j.ijcard.2012.12.089

Cited by 25 publications

(27 citation statements)

References 31 publications

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“…The absence of vagal reinnervation and the presence of sympathetic reinnervation may explain the association between increased HR at rest and increased leptin levels through cardiac leptin receptors . A resting HR ≥90 or 100 beats per minute (bpm) in early recipients at 1 year post‐HTx was found in multivariate analyses to be an independent predictor of mortality following transplantation . Recipients with higher baseline HR ≥90 bpm at 1 year post‐HTx had lower survival rates at 3, 5, and 10 years post‐HTx when compared with recipients with HR <90 bpm …”

Section: Heart Rate At Restmentioning

confidence: 99%

“…A resting HR ≥90 or 100 beats per minute (bpm) in early recipients at 1 year post‐HTx was found in multivariate analyses to be an independent predictor of mortality following transplantation . Recipients with higher baseline HR ≥90 bpm at 1 year post‐HTx had lower survival rates at 3, 5, and 10 years post‐HTx when compared with recipients with HR <90 bpm …”

Section: Heart Rate At Restmentioning

confidence: 99%

See 1 more Smart Citation

Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review

Awad

Czer

Hou

et al. 2016

JAHA

105

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Section: Heart Rate At Restmentioning

confidence: 99%

Section: Heart Rate At Restmentioning

confidence: 99%

Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review

Awad

Czer

Hou

et al. 2016

JAHA

105

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“…Current data on the effects of increased resting HR on all‐cause mortality in HTx patients and CAV development are contradictory. While there is relatively uniform evidence of tachycardia‐related effects on mortality, the impact on CAV development is less clear . Due to small sample sizes, retrospective and observational approaches, and overall design, previous studieshave failed to produce convincing data on the role of tachycardia in CAV development.…”

Section: Discussionmentioning

confidence: 99%

“…Compared to other studies, a relatively high proportion of patients in our cohort were prescribed beta blockers (51.7% at M1, 66.4% at M12). There are three possible explanations for this: (a) Assumption that increased HR predicts worse outcomes in cardiovascular disease could be associated with over‐prescription of beta blockers to achieve resting HR <95‐100/min; (b) favoured beta blockers for the treatment of symptomatic atrial ectopy which can be indirectly suggested by higher frequency of atrial premature complexes on 24‐hour ECG Holter observed at 1 month in patients treated with beta blockers; (c) preference of beta blockers in combination treatment of arterial hypertension.…”

Section: Discussionmentioning

confidence: 99%

Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3‐D optical coherence tomography analysis

Pazderník

Wichterle

Chen

et al. 2020

Clinical Transplantation

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Introduction Heart rate slowing agents are frequently prescribed to manage heart transplant (HTx) patients with the assumption that higher heart rate is a risk factor in cardiovascular disease. Patients and Methods This prospective two‐center study investigated early progression of cardiac allograft vasculopathy (CAV) in 116 HTx patients. Examinations by coronary optical coherence tomography and 24‐hour ambulatory ECG monitoring were performed both at baseline (1 month after HTx) and during follow‐up (12 months after HTx). Results During the first post‐HTx year, we observed a significant reduction in the mean coronary luminal area from 9.0 ± 2.5 to 8.0 ± 2.4 mm2 (P < .001), and progression in mean intimal thickness (IT) from 106.5 ± 40.4 to 130.1 ± 53.0 µm (P < .001). No significant relationship was observed between baseline and follow‐up mean heart rates and IT progression (R = .02, P = .83; R = −.13, P = .18). We found a mild inverse association between beta‐blocker dosage at 12 months and IT progression (R = −.20, P = .035). Conclusion Our study did not confirm a direct association between mean heart rate and progression of CAV. The role of beta blockers warrants further investigation, with our results indicating that they may play a protective role in early CAV development.

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“…We divided the patients into 2 groups: Group A (n = 278) with an average heart rate < 90/min, and Group B (n = 52) with a heart rate ≥ 90/min. We chose the cut off value for heart rate as 90/min based on previously published literature (8,9,10). Echocardiography was performed at time of Holter monitoring, ejection fraction was assessed by Simpson's biplane according to the guidelines.…”

Section: Methodsmentioning

confidence: 99%

Association between the heart rate early after heart transplantation and the long term clinical outcomes

Bedáňová¹,

Fila²,

Horváth³

et al. 2017

BLL

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BACKGROUND: A strong correlation between a lower heart rate and survival has been demonstrated in various patient populations. The optimal heart rate for heart transplant patients is still unknown. The aim of our study was to evaluate the association between an early heart rate and survival after heart transplantation. MATERIAL AND METHODS: We retrospectively analysed a group of 330 patients, who underwent heart transplantation in our institution from 1994 to 2014 and complete datasets, including 24-hour heart rate monitoring one month after the heart transplantation. Patients were divided in 2 groups: Group A (n = 278) with the average 24-hour heart rate < 90 bpm, and Group B (n = 52) with ≥ 90 bpm. RESULTS: The average period of monitoring was 7.5 ± 5.3 years. No differences in baseline characteristics were observed in both groups of recipients and respective donors. One-year survival in groups A and B was 92 % and 81 %, respectively; 5-year survival was 79 % and 60 %, respectively; and 10-year survival was 66 % and 50 %, respectively (p = 0.001). CONCLUSION: Increased heart rate in the early post-transplant period was signifi cantly associated with a poorer survival rate in patients after heart transplantation (Tab. 2, Fig. 1, Ref. 25). Text in PDF www.elis.sk. KEY WORDS: heart rate early heart transplantation, long term clinical outcomes.

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Long-term prognostic value of elevated heart rate one year after heart transplantation

Cited by 25 publications

References 31 publications

Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review

Early Denervation and Later Reinnervation of the Heart Following Cardiac Transplantation: A Review

Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3‐D optical coherence tomography analysis

Association between the heart rate early after heart transplantation and the long term clinical outcomes

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