Long-Term Protective Effect of Serial Infections with H5N8 Highly Pathogenic Avian Influenza Virus in Wild Ducks

Caliendo, Valentina; Leijten, Lonneke; Bildt, Marco W. G. van de; Poen, Marjolein J; Kok, Adinda; Bestebroer, Theo M.; Richard, Mathilde; Fouchier, Ron A. M.; Kuiken, Thijs

doi:10.1128/jvi.01233-22

Cited by 16 publications

(23 citation statements)

References 35 publications

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“…Comprehensive comparisons of both viral distribution and histopathological observations between experimentally and naturally infected white-tailed eagles imply that viral replication in the brain is responsible for the disease severity and mortality in this species. Caliendo et al (2022) inoculated two species of wild ducks-tufted duck (Aythya fuligula) and mallard (Anas platyrhynchos)-first with 2014 H5N8 HPAI virus and after 9 months with 2016 H5N8 HPAI virus, to test the hypothesis that previous infection with a HPAI virus provides long-term immunity against subsequent infection with another HPAI virus. Both viruses belong to the 2.3.4.4b clade.…”

Section: Hpai In Wild Birdsmentioning

confidence: 99%

Avian influenza overview September – December 2022

Adlhoch¹,

Fusaro²,

Gonzáles³

et al. 2023

EFS2

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Between October 2021 and September 2022 Europe has suffered the most devastating highly pathogenic avian influenza (HPAI) epidemic with a total of 2,520 outbreaks in poultry, 227 outbreaks in captive birds, and 3,867 HPAI virus detections in wild birds. The unprecedent geographical extent (37 European countries affected) resulted in 50 million birds culled in affected establishments. In the current reporting period, between 10 September and 2 December 2022, 1,163 HPAI virus detections were reported in 27 European countries in poultry (398), captive (151) and wild birds (613). A decrease in HPAI virus detections in colony‐breeding seabirds species and an increase in the number of detections in waterfowl has been observed. The continuous circulation of the virus in the wild reservoir has led to the frequent introduction of the virus into poultry populations. It is suspected that waterfowl might be more involved than seabirds in the incursion of HPAI virus into poultry establishments. In the coming months, the increasing infection pressure on poultry establishments might increase the risk of incursions in poultry, with potential further spread, primarily in areas with high poultry densities. The viruses detected since September 2022 (clade 2.3.4.4b) belong to eleven genotypes, three of which have circulated in Europe during the summer months, while eight represent new genotypes. HPAI viruses were also detected in wild and farmed mammal species in Europe and North America, showing genetic markers of adaptation to replication in mammals. Since the last report, two A(H5N1) detections in humans in Spain, one A(H5N1), one A(H5N6) and one A(H9N2) human infection in China as well as one A(H5) infection without NA‐type result in Vietnam were reported, respectively. The risk of infection is assessed as low for the general population in the EU/EEA, and low to medium for occupationally exposed people.

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Section: Hpai In Wild Birdsmentioning

confidence: 99%

Avian influenza overview September – December 2022

Adlhoch¹,

Fusaro²,

Gonzáles³

et al. 2023

EFS2

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“…H5 AIV spread to other regions through bird migration 45 and the poultry trade 46 , and our results reveal a 2-3- year delay between the peak of lineage dissemination from Chinese poultry and the peak of lineage introduction into European poultry. Although it has been suggested that the intercontinental spread of H5 AIV may occur within a single avian migratory cycle 8,45, 47–50 , the delay we observe may be attributed in part to pre-existing immunity in wild birds, which may provide partial protection against infection and disease 51–53 , leading to reduced circulation and potentially dampening large-scale outbreaks in wild birds. However, the duration of protection conferred by previous AIV infection and its impact on the epidemiology of AIV have yet to be elucidated fully 54 .…”

Section: Discussionmentioning

confidence: 63%

Association of poultry vaccination with the interspecies transmission and molecular evolution of H5 subtype avian influenza virus

Li,

Raghwani,

Hill

et al. 2023

Preprint

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The effectiveness of vaccinating poultry in preventing the transmission of highly pathogenic avian influenza viruses (AIVs) has been questioned for years and its impact on wild birds is uncertain1–3. Here we reconstruct movements of H5 subtype AIV lineages among vaccinated poultry, unvaccinated poultry, and wild birds, worldwide from 1996 to 2023. We find that lineage transitions among host types are lagged and that movements from wild birds to unvaccinated poultry were more frequent than those from wild birds to vaccinated poultry. However, we also find that the HA gene of the AIV lineage that circulated predominately among Chinese poultry with high vaccination coverage underwent faster evolution and greater nonsynonymous divergence than other lineages. Further, this Chinese poultry lineage contained more codons inferred to be under positive selection, including at known antigenic sites, and its rates of nonsynonymous divergence and adaptative fixation increased after mass poultry vaccination began. Our results indicate that the epidemiological, ecological and evolutionary consequences of widespread AIV vaccination in poultry may be linked in complex ways, and that much work is needed to better understand how such interventions may affect AIV transmission to, within and from wild birds.

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“…Wade, Ashton-Butt, Scott et al suggest other measurements to detect and count infected wild birds such as utilisation and expansion of hunter harvested AI surveillance network [ 19 ]. Furthermore, some wild bird species may have developed antibodies overtime which could have influenced the observed and recorded numbers in some areas [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Spread of avian influenza among poultry specialists in England during winter 2022/23: National poultry housing order and environmental drivers

Tammes

2024

Dialogues in Health

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Long-Term Protective Effect of Serial Infections with H5N8 Highly Pathogenic Avian Influenza Virus in Wild Ducks

Cited by 16 publications

References 35 publications

Avian influenza overview September – December 2022

Avian influenza overview September – December 2022

Association of poultry vaccination with the interspecies transmission and molecular evolution of H5 subtype avian influenza virus

Spread of avian influenza among poultry specialists in England during winter 2022/23: National poultry housing order and environmental drivers

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