Long-term psychiatric outcomes in pediatric brain tumor survivors

Shah, Sumedh S.; Dellarole, Anna; Peterson, Eric C.; Bregy, Amadé; Komotar, Ricardo J.; Harvey, Philip D.; Elhammady, Mohamed Samy

doi:10.1007/s00381-015-2669-7

Cited by 78 publications

(57 citation statements)

References 25 publications

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“…Systematic and narrative reviews describe CCS as experiencing lower psychological well‐being, greater anxiety, more problem behaviors, and more PTSS . Brain tumor survivors report greater depression, anxiety, suicidal ideation, and behavioral problems . Studies of acute lymphoblastic leukemia survivors report higher risk for adverse psychological outcomes such as depression and somatic distress …”

Section: Resultsmentioning

confidence: 99%

“…Future research should validate SMART among other populations with special health care needs.Research question clearly stated; qualitative approach clearly justified; study context clearly described; role of the researcher clearly described; sampling strategy appropriate for research question; method of data collection clearly described; method of data analysis clearly described; issues with follow‐up or missing data clearly described4, 6xShah, 2015 Long‐term psychiatric outcomes in pediatric brain tumor survivors. Child's nervous system: ChNS: official journal of the International Society for Pediatric Neurosurgery Systematic review.…”

Section: Supplementary Informationmentioning

confidence: 99%

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Psychosocial Follow‐Up in Survivorship as a Standard of Care in Pediatric Oncology

Lown

Phillips

Schwartz

et al. 2015

Pediatric Blood & Cancer

110

113

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Childhood cancer survivors (CCS) have a high risk of medical late effects following cancer therapy. Psychosocial late effects are less often recognized. Many CCS do not receive long-term follow-up (LTFU) care, and those who do are rarely screened for psychosocial late effects. An interdisciplinary team conducted a systematic review of qualitative and quantitative studies to assess social, educational, vocational, psychological, and behavioral outcomes along with factors related to receipt of LTFU care. We propose that psychosocial screening be considered a standard of care in long-term follow-up care and that education be provided to promote the use LTFU care starting early in the treatment trajectory.

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Section: Resultsmentioning

confidence: 99%

Section: Supplementary Informationmentioning

confidence: 99%

Psychosocial Follow‐Up in Survivorship as a Standard of Care in Pediatric Oncology

Lown

Phillips

Schwartz

et al. 2015

Pediatric Blood & Cancer

110

113

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show abstract

“…Nevertheless, a large body of evidence shows that cancer and its treatments have long‐term and lasting adverse effects on the psychological well‐being and neurocognitive functioning of childhood cancer survivors . In particular, survivors of pediatric brain tumors reportedly have more negative psychological and cognitive sequela than do survivors of other childhood cancers . The long‐term neuropsychiatric conditions in cancer survivors, such as depression, anxiety, and behavioral and social problems, may result from damage to neural cells as a result of a brain tumors or its treatment, as well as potential interactions with psychological adjustments .…”

Section: Introductionmentioning

confidence: 99%

“…Pediatric brain tumors survivors' quality of life is severely compromised because of the devastating effects imposed by the tumor and sequela of its treatment, which appear across domains of cognitive, physical, and psychological functioning . Coping with psychological sequela is a distressing experience for survivors of pediatric brain tumors, leading to long‐term decrement of their quality of life …”

Section: Introductionmentioning

confidence: 99%

Efficacy of musical training on psychological outcomes and quality of life in Chinese pediatric brain tumor survivors

Cheung¹,

Ho²,

Lam³

et al. 2018

Psycho-Oncology

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Background Evidence has shown that survivors of pediatric brain tumors have more negative psychological sequela, particularly depression, than do survivors of other childhood cancers. This study examined the efficacy of a musical training program in reducing depressive symptoms and enhancing self‐esteem and quality of life in Hong Kong Chinese pediatric brain tumor survivors. Methods A prospective randomized controlled trial, two‐group pretest and repeated posttest, between‐subjects design was conducted to 60 pediatric brain tumor survivors (8‐5 years old). Participants in the experimental group received a weekly 45‐min lesson on musical training for 52 weeks. Participants in the control group received a placebo intervention. The primary outcome was depressive symptoms at 12 months. Secondary outcomes were self‐esteem and quality of life at 12 months. Data were collected at baseline and 6 and 12 months after the intervention began. Results Participants in the experimental group reported statistically significant fewer depressive symptoms (P < 0.001), higher levels of self‐esteem (P < 0.001), and better quality of life (P < 0.001) than the control group at 12‐month follow‐up. Conclusions This study provides evidence that musical training is effective in reducing depressive symptoms and enhancing self‐esteem and quality of life in Hong Kong Chinese pediatric brain tumor survivors. These results indicate that musical training is not only a leisure activity but also carries therapeutic effects in promoting psychological well‐being and quality of life in pediatric brain tumor survivors.

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“…These tumors are also highly aggressive, difficult to treat, and result in high morbidity and mortality rates. Furthermore, current treatment modalities for these pediatric brain tumors, including RT and chemotherapy (CT), demonstrate long-term effects on development, such as cognitive dysfunction, neuroendocrine dysregulation, and developmental delays [11,12]. The dismal medial survival time has been attributed to the existence of the multiple drug resistance capabilities of HGGs (e.g., treatment resistant cancer stem cells, up-regulation of drug resistant genes, pro-survival responses such as autophagy, etc.)…”

Section: Introductionmentioning

confidence: 99%

Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives

et al. 2016

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Resistance mechanisms employed by high-grade gliomas allow them to successfully evade current standard treatment of chemotherapy and radiation treatment. Withaferin A (WA), utilized in Ayurvedic medicine for centuries, is attracting attention for its antitumor capabilities. Here we review pertinent literature on WA as a high-grade glioma treatment, and discuss the cancerous mechanisms it affects. WA is relatively nontoxic and has shown potential in crossing the blood-brain barrier. WA prevents p53 alterations and inactivates overexpressed MDM2 through ARF and ROS production. Furthermore, WA upregulates Bax, inducing mitochondrial death cascades, inhibits mutated Akt, mTOR, and NF-κB pathways, and inhibits angiogenesis in tumors. Therapy with WA for high-grade gliomas is supported through the literature. Further investigation is warranted and encouraged to fully unearth its abilities against malignant gliomas.

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Long-term psychiatric outcomes in pediatric brain tumor survivors

Cited by 78 publications

References 25 publications

Psychosocial Follow‐Up in Survivorship as a Standard of Care in Pediatric Oncology

Psychosocial Follow‐Up in Survivorship as a Standard of Care in Pediatric Oncology

Efficacy of musical training on psychological outcomes and quality of life in Chinese pediatric brain tumor survivors

Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives

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