Long‐term psychosocial adjustment of older vs younger survivors of breast and endometrial cancer

Kornblith, Alice B.; Powell, Mark; Regan, Meredith M.; Bennett, Samantha; Krasner, Carolyn; Moy, Beverly; Younger, Jerry; A, Goodman; Berkowitz, Ross S.; Winer, Eric P.

doi:10.1002/pon.1146

Cited by 185 publications

(174 citation statements)

References 36 publications

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“…With growing age, physical problems are likely to increase, even irrespective of the cancer diagnosis. However, the finding that age was not predictive of other QoL domains contradicts the hypothesis, as well as previous studies that have reported greater distress in younger breast cancer patients in both the short term and long term [7][8][9]. This greater impairment of QoL in the younger age group was explained by greater work-related and family-related demands, less adequate strategies for coping with disease, and health-related restrictions.…”

Section: Age As a Sociodemographic Predictor And Oncological Predictorscontrasting

confidence: 55%

“…The selection of age, tumor size, axillary surgery, and adjuvant chemotherapy as sociodemographic and oncological impact factors on the QoL of breast cancer patients is based on clinical studies [1][2][3][4][5][6][7][8][9]. The impact of primary surgical treatment (BCT vs mastectomy), especially in relation to long-term body image, would also have been of interest [3,5], but the very small subgroup of patients treated with mastectomy (8%) did not allow statistical analysis.…”

Section: Limitations Of the Studymentioning

confidence: 99%

“…Most studies have focused on clinical factors affecting QoL in breast cancer patients, such as the type of surgery, adjuvant treatment, clinical tumor size, number of positive axillary nodes, and comorbidity [1][2][3][4][5]. Age has been examined as a possible sociodemographic impact factor affecting QoL [6][7][8][9]. Other sociodemographic factors, such as marital status, living situation, education level, and occupation have been investigated to a lesser extent [2,4].…”

Section: Introductionmentioning

confidence: 99%

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Personality traits and psychosocial stress: quality of life over 2 years following breast cancer diagnosis and psychological impact factors

Engel²,

et al. 2009

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Objective: The aim of this study was to investigate changes in the quality of life (QoL) and body image among breast cancer patients over 2 years and to examine different predictive factors for QoL 2 years after the primary operation.Methods: A total of 203 women with a primary diagnosis of breast cancer completed the questionnaires 2 weeks and 6, 12, 18, and 24 months after surgery. Quality of Life Questionnaire (QLQ-C30), Breast Cancer Specific Quality of Life Questionnaire Module (QLQ-BR23), Questionnaire on Stress in Cancer Patients (QSC-R23), Freiburg Personality Inventory (FPI-R), Life Orientation Test (LOT) were used as standardized measures.Results: The overall QoL and most functional and symptom scales improved during the 2-year period. However, cognitive functioning, body image, and the three symptom scales of insomnia, constipation, and diarrhea did not change. Age was only capable of predicting physical functioning, whereas tumor size, axillary surgery, and adjuvant chemotherapy were not predictive of the long-term QoL functional scores. Initial distress was the most potent predictive factor for long-term QoL. Baseline functioning predicted functional QoL scores 2 years later. And higher scores for neuroticism were associated with a poorer QoL. However, optimism was not capable of predicting the QoL 2 years later.Conclusion: Screening measures should be implemented at the time when breast cancer is diagnosed, in order to identify psychologically vulnerable patients and offer them professional psycho-oncological help.

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Section: Age As a Sociodemographic Predictor And Oncological Predictorscontrasting

confidence: 55%

Section: Limitations Of the Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Personality traits and psychosocial stress: quality of life over 2 years following breast cancer diagnosis and psychological impact factors

Engel²,

et al. 2009

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“…A higher score on this questionnaire indicates better body image. The average scores for the dragon boaters in the current study was 3.03 ± 0.4, (Range = 2.29-3.57), which was significantly higher than the non-dragon boating survivors (2.58 ±0.81; p = 0.018) (Kornblith et al, 2007).…”

Section: Psychosocial Measurements: Dragon Boat Racing Versus Populatmentioning

confidence: 91%

“…Scores were compared with subjects in a study of 252 breast and endometrial cancer survivors who ranged in age from 55 to 65 years old, were recruited from 2003 to 2004, and ranged from 2.9 to 4.5 years posttreatment. This population was 93% white while 78% were married (Kornblith et al, 2007). A higher score on this questionnaire indicates better body image.…”

Section: Psychosocial Measurements: Dragon Boat Racing Versus Populatmentioning

confidence: 99%

An Exploratory Investigation of the Effects of Dragon Boating on the Psychosocial Well-Being of Female Cancer Survivors

Vanherweg¹

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Effect of Unblinding on Participants' Perceptions of Risk and Confidence in a Large Double-Blind Clinical Trial of Chemotherapy for Breast Cancer

et al. 2015

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Importance Blinding patients to treatment regimen is an important component of high quality randomized clinical trials (RCT) although concern exists about how receipt of a placebo will impact participants’ views, particularly among patients with cancer. Objective To determine if unblinding of random assignment to placebo vs. experimental agent in a large adjuvant breast cancer chemotherapy randomized controlled trial was associated with perception of greater chance of cancer recurrence, and lower confidence in the decision to participate in the trial in participants who were randomized to placebo compared to those randomized to experimental therapy. Design Serial telephone based prospective surveys. Setting In ECOG5103, patients were randomized to receive standard adjuvant chemotherapy for breast cancer with either placebo or bevacizumab for either ~6 or ~12 months. Treatment assignment was unblinded by 24 weeks. Participants All patients enrolling in E5103 between 1/5-6/8/10 were included in this sub-study. Patients were surveyed after unblinding of their randomization allocation. Main Outcome and Measure Survey items including perceived risk of recurrence and confidence in study participation. Results 571 patients on this sub-study started protocol therapy, 550 were still on study at unblinding and 492 responded to the unblinding survey. At unblinding, most respondents, 70% (336/477), felt they had at most a small risk of breast cancer recurrence, 71% (342/480) reported perceiving at most a small risk of serious problem with therapy; the vast majority reported feeling very informed and having high levels of confidence in their study participation (87% for both (421/483 and 420/483 respectively)). Participants who learned they had been randomized to placebo did not have greater perception of chance of recurrence (p=0.48) or fear of recurrence (p=0.69), feel less informed (p=0.86) or have lower confidence in trial participation (p=0.31) compared to those who had been randomized to experimental therapy. Patients who learned they had been randomized to bevacizumab perceived higher risk of having a serious problem caused by treatment (p=0.01). Conclusions and Relevance In a placebo-controlled, double-blinded RCT, unblinding to randomization allocation did not significantly affect most participants’ views except for chance of a serious problem from experimental treatment, regardless of receipt of placebo or experimental anti-cancer therapy along with standard chemotherapy. Parent Trial Registration NCT00433511

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Long‐term psychosocial adjustment of older vs younger survivors of breast and endometrial cancer

Cited by 185 publications

References 36 publications

Personality traits and psychosocial stress: quality of life over 2 years following breast cancer diagnosis and psychological impact factors

Personality traits and psychosocial stress: quality of life over 2 years following breast cancer diagnosis and psychological impact factors

An Exploratory Investigation of the Effects of Dragon Boating on the Psychosocial Well-Being of Female Cancer Survivors

Effect of Unblinding on Participants' Perceptions of Risk and Confidence in a Large Double-Blind Clinical Trial of Chemotherapy for Breast Cancer

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