Long-Term Quality of Life in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma

Nies, Marloes; Hesselink, Mariëlle S Klein; Huizinga, Gea A.; Sulkers, Esther; Brouwers, Adrienne H.; Burgerhof, Johannes G. M.; Dam, Eveline W. C. M. van; Havekes, Bas; Heuvel‐Eibrink, Marry M. van den; Corssmit, Eleonora P M; Kremer, Leontien C. M.; Netea‐Maier, Romana T.; Pal, Heleen J H van der; Peeters, Robin P.; Plukker, John; Ronckers, Cécile M.; Santen, Hanneke M van; Tissing, Wim J. E.; Links, Thera P.; Bocca, Gianni

doi:10.1210/jc.2016-2246

Cited by 30 publications

(68 citation statements)

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“…However, our study has some potentially important improvements compared with these previous reports. [ 10 , 15 , 18 ] First, we compared the baseline HRQoL of 186 PTC patients with that of the 186 subjects from the general population and found that all 8 domains of HRQOL were lower in the PTC patients; 7 domains were significantly different. Second, we have identified PTC and diabetes or hypertension as risk factors for lower HRQOL scores.…”

Section: Discussionmentioning

confidence: 99%

Health-related quality-of-life assessment in surgical patients with papillary thyroid carcinoma

et al. 2017

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Even with a favorable prognosis, the health-related quality of life (HRQoL) of papillary thyroid carcinoma (PTC) patients remains unclear and conflicting. Thus, in the present study, we compared the HRQoL of PTC patients with that of the general population (GP).The study was performed in our thyroid and parathyroid surgery department, and 186 PTC patients who had undergone thyroidectomy were included. The exclusion criteria were an age < 18 years, no follow-up, and the presence of other malignant neoplasms. The control group included 186 volunteers who were matched by age, gender, and socioeconomic status. The survivor and control groups were asked to complete the Chinese version of the SF-36 questionnaire.The 186 volunteers from the GP were well matched to PTC patients with respect to the baseline demographic characteristics. PTC patients showed significantly lower scores than those of the control group in 7 domains of the HRQoL: role-physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role-emotional (RE), and mental health (MH). PTC was a risk factor for a low Physical Component Summary (PCS) score and a low Mental Component Summary (MCS) score (all P values were less than .05). Significant reductions in the scores of all 8 domains were observed at 1 month after the operation, and obvious recovery was noted at 6 months according to the PCS and MCS scores (all P values were less than .05). However, even 2 years after surgery, few domain scores had recovered to levels found in the GP, including the PCS and MCS scores (all P values were less than .05).Due to the decreased preoperative and postoperative HRQoL scores, much attention should be given to and more long-term observation should be performed for PTC patients, even those who have undergone surgery.

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Section: Discussionmentioning

confidence: 99%

Health-related quality-of-life assessment in surgical patients with papillary thyroid carcinoma

et al. 2017

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“…The favourable outcomes for young adults with phenylketonuria and females with Fabry disease could be that these diseases have few long‐term somatic effects if they are treated successfully . The excellent prognosis and low school absence rate could explain the favourable psychosocial development of young adults treated for differentiated thyroid carcinoma . With regard to vitiligo, it is interesting to note that patients who had negative experiences with their vitiligo during childhood did show any delay in their social development …”

Section: Discussionmentioning

confidence: 99%

Review about the impact of growing up with a chronic disease showed delays achieving psychosocial milestones

et al. 2019

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Aim This review aimed to provide a comprehensive overview of the psychosocial developmental trajectory of various diseases during childhood and adolescence. Methods Studies of Dutch young adults aged 18‐35 years, who had grown up with a chronic disease, were included if the Course of Life Questionnaire had been used to assess psychosocial developmental milestones in three domains: social, autonomy and psychosexual. Differences between the disease groups and the general population were presented as Cohen's d and odds ratios. Results We included 17 studies comprising 1899 young adults, who had grown up with 18 different paediatric diseases. Psychosocial development was delayed in all three questionnaire domains. Remarkable findings with regard to specific milestones were as follows: less participation in sports clubs in the social domain, less likely to have had paid jobs in the autonomy domain and later sexual intimacy in the psychosexual domain. End‐stage renal disease, galactosaemia (males), childhood cancer and orthotopic liver transplants were the most affected disease groups. Conclusion Children and adolescents with chronic diseases risked delays in psychosocial development. This should be addressed by healthcare providers, along with the physical aspects of diseases, and they should focus on the optimal psychosocial development of the patient.

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“…For the nationwide study, all patients diagnosed with DTC at age ≤18 years between 1970 and 2013 treated in the Netherlands were included ( 5 ). Exclusion criteria were, as previously reported: follow-up <5 years after diagnosis, attained age <18 years, diagnosis of DTC as a second malignant neoplasm, lack of understanding of the Dutch language, and 131-I administration within three months before evaluation ( 19 ). For the current study, survivors aged >35 years during evaluation were also excluded because the questionnaire is validated only up to the age of 35 years ( 7 ).…”

Section: Methodsmentioning

confidence: 99%

“…Although we preferred peers (e.g. friends, colleagues), we allowed inclusion of family members, provided they met the in/exclusion criteria ( 19 ). For the current substudy, peer controls aged >35 years were also excluded.…”

Section: Methodsmentioning

confidence: 99%

Psychosocial development in survivors of childhood differentiated thyroid carcinoma: a cross-sectional study

Nies¹,

Dekker²,

Sulkers³

et al. 2018

European Journal of Endocrinology

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ObjectiveThe impact of childhood differentiated thyroid carcinoma (DTC) on psychosocial development has not yet been studied. The aim of this study was to evaluate the achievement of psychosocial developmental milestones in long-term survivors of childhood DTC.Design and methodsSurvivors of childhood DTC diagnosed between 1970 and 2013 were included. Reasons for exclusion were age <18 or >35 years at follow-up, a follow-up period <5 years or diagnosis with DTC as a second malignant neoplasm. Survivors gathered peer controls of similar age and sex (n = 30). A comparison group non-affected with cancer (n = 508) and other childhood cancer survivors (CCS) were also used to compare psychosocial development. To assess the achievement of psychosocial milestones (social, autonomy and psychosexual development), the course of life questionnaire (CoLQ) was used.ResultsWe included 39 survivors of childhood DTC (response rate 83.0%, mean age at diagnosis 15.6 years, and mean age at evaluation 26.1 years). CoLQ scores did not significantly differ between survivors of childhood DTC and the two non-affected groups. CoLQ scores of childhood DTC survivors were compared to scores of other CCS diagnosed at similar ages (n = 76). DTC survivors scored significantly higher on social development than other CCS, but scores were similar on autonomy and psychosexual developmental scales.ConclusionsSurvivors of childhood DTC showed similar development on social, autonomy, and psychosexual domains compared to non-affected individuals. Social development was slightly more favorable in DTC survivors than in other CCS, but was similar on autonomy and psychosexual domains.

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Long-Term Quality of Life in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma

Abstract: Overall, long-term QoL in survivors of pediatric DTC was normal. Survivors experienced mild impairment of QoL in some domains (physical problems, mental fatigue, and various thyroid cancer-specific complaints). Factors possibly affecting QoL need further exploration.

Cited by 30 publications

References 35 publications

Health-related quality-of-life assessment in surgical patients with papillary thyroid carcinoma

Health-related quality-of-life assessment in surgical patients with papillary thyroid carcinoma

Review about the impact of growing up with a chronic disease showed delays achieving psychosocial milestones

Psychosocial development in survivors of childhood differentiated thyroid carcinoma: a cross-sectional study

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