Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners

Scholten, Shane D.; Сергеев, И. Н.

doi:10.2147/oajsm.s39632

Cited by 21 publications

(17 citation statements)

References 31 publications

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“…However, PO max increased 19% in the post-supplementation period compared to baseline values, although this was not statistically significant.These findings are consistent with published values on the ergogenic effect of quercetin supplementation in humans [16][17][18][19], although contrary findings have also been reported [20,38,39]. Furthermore, Scholten&Sergeev have found that quercetin supplementation (6 week, 1000 mg/day) did not enhance performance as measured by VO2 peak running economy, heart rate, and rating of perceived exertion but quercetin can reduced oxidative stress as measured by malondialdehyde as a marker of lipid peroxidation [40]. Ganio et al found that 5 days of quercetin supplementation did not improve VO2max in untrained, sedantary individuals [38].…”

Section: Discussionsupporting

confidence: 90%

The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response

Pündük¹,

Hişmioğulları²,

Yavuz

et al. 2015

AJSS

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The effect of antioxidant supplementation on exercise performance has not been clearly defined in trained or untrained individuals. The purpose of this investigation was to test the effects of quercetin-resveratrol combination on plasma anti-inflammatory response and exercise performance in untrained men. After baseline cycling performance testing, the subjects (n=8) were supplemented daily with 500gr quercetin and 500 gr resveratrol for 21 days. The complete blood counts, creatinine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), interleukin-6 (IL-6), Neutrophil gelatinase-associated lipocalin (NGAL) and exercise performance parameters were evaluated at baseline, after 21 days of supplementation and 15 days after the end of the study. The maximal aerobic power (POmax) was increased (19%) in the post-supplementation period compare to baseline and washout period. In the post-supplementation period, the time trial score (TTscore), maximal and average speed significantly increased in the 10 km time trial cycling test compare to the baseline level. Importantly, in response to supplementation, the serum IL-6 and N-GAL levels were upregulated post-supplementation and these levels returned to baseline levels at the end of the washout period. These results suggest that dieatary combination of quercetin and resveretrol may act as a potential tool for enhancing exercise performance by regulation IL-6, NGAL level in untrained men.

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Section: Discussionsupporting

confidence: 90%

The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response

Pündük¹,

Hişmioğulları²,

Yavuz

et al. 2015

AJSS

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“…We previously reported that supplementation of trained participants with 1,000 mg/d of quercetin for 6 weeks tends to increase VO 2 max , suggesting a slight improvement in cardiorespiratory fitness through reducing oxidative stress. 18 …”

Section: Discussionmentioning

confidence: 99%

“… 12 – 14 However, it remains unclear whether quercetin supplementation increases antioxidant status or reduces oxidative stress, leading to enhanced physical performance. 4 , 15 – 18 …”

Section: Introductionmentioning

confidence: 99%

Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults

Scholten¹,

Сергеев²,

Song³

et al. 2015

OAJSM

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IntroductionVitamin D and the antioxidant quercetin, are promising agents for improving physical performance because of their possible beneficial effects on muscular strength and cardiorespiratory fitness.PurposeThe purpose of this study was to determine the effects of increased intakes of vitamin D, quercetin, and their combination on antioxidant status, the steroid hormone regulators of muscle function, and measures of physical performance in apparently healthy male adults engaged in moderate-to-vigorous-intensity exercise training.MethodsA total of 40 adult male participants were randomized to either 4,000 IU vitamin D/d, 1,000 mg/d quercetin, vitamin D plus quercetin, or placebo for 8 weeks. Measures of cardiorespiratory fitness and muscle function, blood markers for antioxidant and vitamin D status, and hormones 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and testosterone were measured pre- and postsupplementation.ResultsAt enrollment, 88.6% of participants were vitamin D sufficient (serum 25-hydroxyvitamin D >50 nmol/L) and had normal serum testosterone levels. Supplementation with vitamin D significantly increased serum 25(OH)D concentration (by 87.3% in the vitamin D group, P<0.001) and was associated with an increasing trend of testosterone concentration. There were no changes in concentration of 1,25(OH)2D3 and markers of antioxidant status associated with vitamin D or quercetin supplementation. No improvements in physical performance measures associated with vitamin D and quercetin supplementation were found.ConclusionThe findings obtained demonstrate that long-term vitamin D and quercetin supplementation, alone or in combination, does not improve physical performance in male adults with adequate vitamin D, testosterone, and antioxidant status.

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“…We did not identify any adaptations in response to quercetin treatment that would exert an ergogenic effect on endurance performance. While many studies have reported quercetin's ergogenic effect on endurance exercise [6][7][8][9], other studies have shown no effect of chronic quercetin treatment [11,36,37]. Importantly, Casuso et al [27] demonstrated that chronic quercetin treatment and exercise training impaired training-induced citrate synthase adaptation in skeletal muscle.…”

Section: Discussionmentioning

confidence: 99%

Effect of Quercetin Treatment on Mitochondrial Biogenesis and Exercise-Induced AMP-Activated Protein Kinase Activation in Rat Skeletal Muscle

et al. 2020

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The purpose of this study was to evaluate the effect of chronic quercetin treatment on mitochondrial biogenesis, endurance exercise performance and activation levels of AMP-activated protein kinase (AMPK) in rat skeletal muscle. Rats were assigned to a control or quercetin group and were fed for 7 days. Rats treated with quercetin showed no changes in the protein levels of citrate synthase or cytochrome C oxidase IV or those of sirtuin 1, peroxisome proliferator-activated receptor gamma coactivator-1α or phosphorylated AMPK. After endurance swimming exercise, quercetin-treated rats demonstrated no differences in blood and muscle lactate levels or glycogen utilization speed compared to control rats. These results indicate that quercetin treatment does not stimulate mitochondrial biogenesis in skeletal muscle and does not influence metabolism in a way that might enhance endurance exercise capacity. On the other hand, the AMPK phosphorylation level immediately after exercise was significantly lower in quercetin-treated muscles, suggesting that quercetin treatment might provide a disadvantage to muscle adaptation when administered with exercise training. The molecular results of this study indicate that quercetin treatment may not be advantageous for improving endurance exercise performance, at least after high-dose and short-term therapy.

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Long-term quercetin supplementation reduces lipid peroxidation but does not improve performance in endurance runners

Cited by 21 publications

References 31 publications

The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response

The Dietary Combination of Quercetin and Resveratrol Supplementation May Improve Exercise Tolerance in Young Untrained Males by Modulating IL-6 and NGAL Response

Effects of vitamin D and quercetin, alone and in combination, on cardiorespiratory fitness and muscle function in physically active male adults

Effect of Quercetin Treatment on Mitochondrial Biogenesis and Exercise-Induced AMP-Activated Protein Kinase Activation in Rat Skeletal Muscle

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