Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting

Gholampour, Seifollah; Frim, David M.; Yamini, Bakhtiar

doi:10.1038/s42003-022-04128-8

Cited by 13 publications

(23 citation statements)

References 92 publications

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“…In the future, more prospective multicenter studies can be used to validate our findings and elucidate the underlying mechanisms. Recent studies have reported that BP and hemodynamic changes are effective indicators in the diagnosis and treatment of large groups of brain disorders 45,46 . Therefore, with methodological adaptation (e.g., including other proposed metrics of cerebral circulation), the findings might be extended to the cohorts with other brain disorders, for example, hydrocephalus and cerebral atrophy, to enable the early detection of severe symptoms and improve the diagnosis and treatment 47 …”

Section: Discussionmentioning

confidence: 99%

Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring

Li,

Wu,

Dong

et al. 2024

J of Clinical Hypertension

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Progressive cerebral infarction (PCI) is a common complication in patients with ischemic stroke that leads to poor prognosis. Blood pressure (BP) can indicate post‐stroke hemodynamic changes which play a key role in the development of PCI. The authors aim to investigate the association between BP‐derived hemodynamic parameters and PCI. Clinical data and BP recordings were collected from 80 patients with cerebral infarction, including 40 patients with PCI and 40 patients with non‐progressive cerebral infarction (NPCI). Hemodynamic parameters were calculated from the BP recordings of the first 7 days after admission, including systolic and diastolic BP, mean arterial pressure, and pulse pressure (PP), with the mean values of each group calculated and compared between daytime and nighttime, and between different days. Hemodynamic parameters and circadian BP rhythm patterns were compared between PCI and NPCI groups using t‐test or non‐parametric equivalent for continuous variables, Chi‐squared test or Fisher's exact test for categorical variables, Cox proportional hazards regression analysis and binary logistic regression analysis for potential risk factors. In PCI and NPCI groups, significant decrease of daytime systolic BP appeared on the second and sixth days, respectively. Systolic BP and fibrinogen at admission, daytime systolic BP of the first day, nighttime systolic BP of the third day, PP, and the ratio of abnormal BP circadian rhythms were all higher in the PCI group. PCI and NPCI groups were significantly different in BP circadian rhythm pattern. PCI is associated with higher systolic BP, PP and more abnormal circadian rhythms of BP.

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Section: Discussionmentioning

confidence: 99%

Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring

Li,

Wu,

Dong

et al. 2024

J of Clinical Hypertension

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“…This work represents an innovation in the characterization of LP-based drug-delivery systems that can be extended to different types of nanoparticles for the treatment of many diseases. The formulations presented here were tested for crossing the BBB and releasing specific drugs into the diseased area of the brain; for this reason, they can be potentially developed and optimized for other neurological diseases besides AD and GBM, including the case of hydrocephalus patients, where the BBB has been a great hurdle for drug delivery to the brain [ 46 , 47 ]. Such a deep Raman analysis was proposed here for the first time to study functionalized LPs as therapeutics for brain diseases.…”

Section: Discussionmentioning

confidence: 99%

Raman Spectroscopy Characterization of Multi-Functionalized Liposomes as Drug-Delivery Systems for Neurological Disorders

et al. 2023

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The characterization of nanoparticle-based drug-delivery systems represents a crucial step in achieving a comprehensive overview of their physical, chemical, and biological features and evaluating their efficacy and safety in biological systems. We propose Raman Spectroscopy (RS) for the characterization of liposomes (LPs) to be tested for the control of neuroinflammation and microglial dysfunctions in Glioblastoma multiforme and Alzheimer’s disease. Drug-loaded LPs were functionalized to cross the blood–brain barrier and to guarantee localized and controlled drug release. The Raman spectra of each LP component were used to evaluate their contribution in the LP Raman fingerprint. Raman data analysis made it possible to statistically discriminate LPs with different functionalization patterns, showing that each molecular component has an influence in the Raman spectrum of the final LP formulation. Moreover, CLS analysis on Raman data revealed a good level of synthetic reproducibility of the formulations and confirmed their stability within one month from their synthesis, demonstrating the ability of the technique to evaluate the efficacy of LP synthesis using small amount of sample. RS represents a valuable tool for a fast, sensitive and label free biochemical characterization of LPs that could be used for quality control of nanoparticle-based therapeutics.

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“…COMSOL Multiphysics (version 5.3; COMSOL, Inc., Burlington, MA, USA) was used for geometrical modeling, mesh generation, and finite element analysis (FEA) to calculate output forces, displacements, von Mises stresses, and cation concentrations in IPMCs. FEA-based simulation is common to solve biological problems [ 23 , 24 , 25 ]. The transport of diluted species and general form partsssial differential equations were used to define Nernst–Planck and Poisson equations, respectively, during FE simulation of IPMCs.…”

Section: Methodsmentioning

confidence: 99%

Enhanced Ionic Polymer–Metal Composites with Nanocomposite Electrodes for Restoring Eyelid Movement of Patients with Ptosis

et al. 2023

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The present study aims to use enhanced ionic polymer–metal composites (IPMC) as an artificial muscle (a soft-active actuator) to restore eyelid movement of patients with ptosis. The previous eyelid movement mechanisms contained drawbacks, specifically in the lower eyelid. We used finite element analysis (FEA) to find the optimal mechanism among two different models (A and B). In addition to common electrodes of IPMC (gold and platinum), the bovine serum albumin (BSA) and microcrystalline cellulose (MCC) polymers, with optimal weight percentages of carbon nanotube (CNT) nanofiller, were also utilized as non-metallic electrodes to improve the efficiency of the IPMC actuator. In both models, IPMC with nanocomposite electrodes had higher efficiency as compared to the metallic electrodes. In model A, which moved eyelids indirectly, IPMC with MCC-CNT electrode generated a higher force (25.4%) and less stress (5.9 times) as compared to IPMC with BSA-CNT electrode. However, the use of model A (even with IPMCs) with nanocomposite electrodes can have limitations such as possible malposition issues in the eyelids (especially lower). IPMC with MCC-CNT nanocomposite electrode under model B, which moved eyelids directly, was the most efficient option to restore eyelid movement. It led to higher displacements and lower mechanical stress damage as compared to the BSA-CNT. This finding may provide surgeons with valuable data to open a window in the treatment of patients with ptosis.

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Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting

Cited by 13 publications

References 92 publications

Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring

Hemodynamic changes in progressive cerebral infarction: An observational study based on blood pressure monitoring

Raman Spectroscopy Characterization of Multi-Functionalized Liposomes as Drug-Delivery Systems for Neurological Disorders

Enhanced Ionic Polymer–Metal Composites with Nanocomposite Electrodes for Restoring Eyelid Movement of Patients with Ptosis

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