Long-term recurrence and death rates after acute pancreatitis

Abstract

We found an identical mortality rate of 15% in the two groups, the only predictive factor being age.

Biliary Pancreatitis : Deadly Threat to the Elderly : Is It a Real Threat ?

“…(1)(2)(3)(4)(5) It may involve local tissues or may spread to involve systemic organs and tissues. (6)(7) .…”

Changing Etiological Incidence of Acute Pancreatitis in AdultsSingle Tertiary Centre Study.

“…Acute pancreatitis,an inflamatory disease of pancreas,having mild self limiting course without any serious complications in 80% to a mortility upto 20% of patients [1] .Among etiological factors,biliary tract stones or sustantial alcohol abuse are associated with upto 80% of cases,the relative frequency depends on the prevalence of alcoholism in the population [2] .Stones in common bile duct account for 38% and alcohol abuse for 36% of cases in developed countries [3,4] .In our study,the commonest etiological factor for acute pancreatits is alcoholism(58%) followed by biliary tract stone(32%).This is because of high prevalence alcoholism mostly of crude home made Alcohol induced pancreatitis is more common among men [5] .In our study also men (62%) are most commonly affected.The median age of onset of alcohol induced acute pancreatitis is in between third and fourth decades [5] .In our study the maximum age incidence is in between 30-39 years(45%). A three fold or higher level of serum amylase and lipase confirms the diagnosis [6] .In our study,95% of patients have three fold or higher serum level of amylase and lipase.CECT is currently the best diagnostic method for pancreatic necrosis [7] .In our study CECT has been done in all patients to exclude pancreatic necrosis in early stage.CT severity index has a good correlation with mortality and morbidity [8] .Most episodes of acute pancreatitis(80%) are mild and self limiting [9] .Organ failure and infection of pancreatic necrosis are important determinants of mortality in patients with acute pancreatitis and the presence of either indicates severe disease [10] .In our study 86% of cases were managed conservatively without any complication,early operative intervention for infection of pancreatic necrosis in 2%,late operative intervention for pseudocyst in 4% and mortality in 4% of cases.…”

“…Acute pancreatitis is an inflamatory disease of pancreas with a wide spectrum of symptoms ranging from mild self limiting course of illness without serious complications in 80% of patients to a substantial mortality upto 20% of Patients [1] .It has a wide range of etiological factors,approximatly 80% cases are associated with biliary calculi or sustained alcohol abuse;the relative frequency of these two factors depends on the prevalence of alcoholism in the population studied [2] .In developed countries,most frequent causes of acute pancreatitis are stones in common bile duct in 38% and alcohol abuse in 36% of cases [3,4] .Gallstone pancreatitis is seen more frequently in women between 50-70 years of age,whereas alcohol-induced panceratitis is more prevalent in young men between 30-45 years of age [5] .Aim of this study was to find out the etiology of acute pancreatitis exclusively in adult patients admitted with the symptoms and signs of acute pancreatitis in the department of surgery at Rajendra Institute of medical sciences,Ranchi.…”

Exacerbated experimental pancreatitis in interleukin-19 knockout mice

“…Pancreatitis is disease characterized by inflammation, fibrosis, and general tissue disruption especially in pancreatic acinar cells, and its progression and pathogenesis are mediated by several inflammatory cytokines and antiinflammatory cytokines that are released form infiltrated monocytes and macrophages [17]. Acute pancreatitis is increasing in the world and 20% of acute pancreatitis is associated with substantial morbidity and mortality [18,19]. The commonest associations of acute pancreatitis are alcohol abuse or gallstone migration.…”