Long-term recurrence-free survival in a patient with pancreatic carcinosarcoma: A case report with a literature review

Zhu, Weiwei; Liu, Tai-Guo; Zhu, Hong

doi:10.1007/s12032-010-9804-9

Cited by 25 publications

(28 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A radical resection, including a pancreaticoduodenectomy, left hepatic lobe resection and local resection, of the gastric mass was performed, however, the patient succumbed to multiple organ failure at 2 months post-surgery. By contrast, in other cases, survival periods of ≤20 months have been reported (10,11). However, 6 months appears to be the most common period for survival (4–7,14).…”

Section: Discussionmentioning

confidence: 90%

“…Sarcomatoid carcinoma occurs in diverse locations throughout the body (2), including the upper respiratory tract, genitourinary tract and upper and lower digestive tracts. Pancreatic carcinosarcoma is also extremely rare and only a few cases have been reported in the literature (3–11). Therefore, this disease remains a diagnostic and therapeutic challenge for surgeons.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Laparoscopic left pancreatectomy for pancreatic sarcomatoid carcinoma: A case report and review of the literature

et al. 2013

View full text Add to dashboard Cite

Sarcomatoid carcinoma of the pancreas is extremely rare. The current report presents a case of carcinosarcoma of the pancreas in a 48-year-old male. Pre-operative computed tomography scans revealed a large complex cystic and solid mass in the tail of the pancreas; the patient underwent a laparoscopic spleen-preserving left pancreatectomy. The tumor was shown to be made of cystic and solid components, with a grossly grey/ white appearance. A histological evaluation of the tumor revealed two elements separated from each other, one component was a pancreatic ductal adenocarcinoma and the other component exhibited a sarcomatous growth pattern, composed of spindle cells and multinucleated giant cells. Immunohistochemically, the epithelial area was positive for cytokeratin (CK) and negative for vimentin, while the sarcomatoid area was negative for CK and positive for vimentin. These observations confirmed a diagnosis of pancreatic carcinosarcoma. Although the patient was treated by gemcitabine following surgery, the outcome was extremely poor and the patient succumbed to sarcomatoid carcinoma three months after the treatment.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Laparoscopic left pancreatectomy for pancreatic sarcomatoid carcinoma: A case report and review of the literature

et al. 2013

View full text Add to dashboard Cite

show abstract

“…[9] Radical resection is the only possible method to cure the disease and the efficacies of chemotherapy and radiotherapy are not definitive. One case report where a patient lived for more than 20 months who received 6 cycles of chemotherapy after radical pancreaticoduodenectomy showed promising prospects in adjuvant therapy following radical resection.…”

Section: Discussionmentioning

confidence: 99%

“…One case report where a patient lived for more than 20 months who received 6 cycles of chemotherapy after radical pancreaticoduodenectomy showed promising prospects in adjuvant therapy following radical resection. [9] On the contrary, 1 patient who received 3 cycles of chemotherapy after radical surgery lived for only 4 months. [22] Although how to improve the prognosis of the PCS is still unknown, we think that comprehensive treatment based on surgery is still the most promising curative method.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic carcinosarcoma mimics malignant intraductal papillary mucinous neoplasm

Li¹,

Liu²,

Chang

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

“…Reilly reported LN metastasis in a 23 years old man with Ewing's sarcoma of pancreas (19). Zhu reported LN metastasis in a case of carcinosarcoma (20). It seems that type of sarcoma is important to decide about LN dissection.…”

Section: Discussionmentioning

confidence: 99%

Primary Pancreas Sarcoma, Optimal Treatment and Prognostic Factors

Omidvari

Nasrolahi

Kadkhodaei

et al. 2015

Rep Radiother Oncol

View full text Add to dashboard Cite

Context: Sarcoma is a rare human cancer and pancreatic sarcoma is even rarer. Its treatment and clinical history and prognosis are not well described.Evidence Acquisition: In this review, we collected all articles in the English language found in PubMed that were published between January 2000 to August 2015 to draw conclusions. We found 170 articles in total and 124 articles were excluded. The remaining 46 reports and information of 55 patients were collected and analyzed.Results: Mean age was 57.1 ± 16.7 years and male/female ratio was 27/28. The most common presenting symptom was pain. In 31 cases no adjuvant treatment was prescribed. Others received different chemotherapy agents and only two cases received radiotherapy. Mean tumor size was 9.0 ± 6.8 cm (1 -27 cm) and the most common type was leiomyosarcoma (16 patients). Nine patients had carcinosarcoma and six cases had MFH. The most common site of metastasis was liver, 14 patients had liver metastasis at presentation. Median survival was 14 months. One, three and five year overall survival were 78.4, 48.5 and 48.5 percent, respectively. We found no effective clinical factor in survival.Conclusions: Pancreatic sarcoma is a rare disease and an optimal treatment, such as surgery, chemotherapy or radiotherapy is not well defined.Keywords: Pancreas, Sarcoma, Treatment ContextMost pancreatic tumors are epithelial cancers. Adenocarcinoma is the most common malignancy in this organ. Stromal pancreatic tumors are usually GIST or neurogenic cancers. Primary sarcoma of pancreas (PS) are very rare and most be differentiated from gastrointestinal and retroperitoneal sarcoma with extension to pancreas (1). Among 15,000 patients who were referred to our center for treatment over a 10-year period (2003 -2013), 95 cases had sarcoma. Among those who had sarcoma, only one case had pancreas sarcoma. Most pancreatic sarcomas (PS) are diagnosed in autopsy (1). Presenting symptoms are nonspecific and are abdominal pain, mass, epigastric tenderness or even may present as acute pancreatitis (1, 2). In order to elucidate the clinical course and behavior and responses to treatment, we searched PubMed for information regarding primary pancreatic sarcoma. Evidence AcquisitionWe searched PubMed for primary pancreatic sarcomas. Only studies that reported clinical data were included in the study. Review articles (without reporting a new case), animal studies and genetic or radiologic studies were excluded. Keywords in the title were: "sarcoma" or "leiomyosarcoma" or "liposarcoma" or "rhabdomyosarcoma" or "mesenchymal" or "malignant fibrous histiocytomas" AND "pancreas" or "pancreatic". Articles that had no information about a new patient or were published before the year 2000 were excluded. Metastasis to pancreas (non-primary pancreatic tumors) and non-English reports were also exclusion criteria.All clinical data, including age, sex, and disease presentation, type of sarcoma, and completeness of resection, treatment, site of metastasis and survival were collected. Some studies r...

show abstract

Long-term recurrence-free survival in a patient with pancreatic carcinosarcoma: A case report with a literature review

Cited by 25 publications

References 7 publications

Laparoscopic left pancreatectomy for pancreatic sarcomatoid carcinoma: A case report and review of the literature

Laparoscopic left pancreatectomy for pancreatic sarcomatoid carcinoma: A case report and review of the literature

Pancreatic carcinosarcoma mimics malignant intraductal papillary mucinous neoplasm

Primary Pancreas Sarcoma, Optimal Treatment and Prognostic Factors

Contact Info

Product

Resources

About