Long-term recurrence of secretory breast carcinoma with metastatic sentinel lymph nodes

Tixier, Hervé; Picard, Anne; Guiu, Séverine; Coudert, Bruno; Loustalot, Catherine; Depret, Olivier; Arnould́, Laurent; Cuisenier, Jean

doi:10.1007/s00404-010-1669-9

Cited by 18 publications

(25 citation statements)

References 11 publications

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“…Secretory breast carcinoma is considered by a few researchers to be more aggressive in adult women than in children. 25,46 Wide excision is potentially adequate due to few occurrences of metastasis in children. For patients over 20 years old, an initial simple mastectomy with axillary node dissection might be adequate.…”

Section: Discussionmentioning

confidence: 99%

Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature

et al. 2012

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Secretory breast carcinoma is a rare breast cancer with indolent clinical behavior. Recent research showed that secretory breast carcinoma belongs to the phenotypic spectrum of basal-like breast carcinomas. In this study, a clinicopathological and immunophenotypic analysis of secretory breast carcinomas from 15 Chinese patients was conducted. This patient group consisted of 2 males and 13 females, with ages ranging from 10 to 67 years old (median, 36 years old). All patients presented with a painless and firm mass. Tumor size ranged from 10 to 55 mm. Most tumors were located in the outer upper quadrant of the breast. Two patients (2 of 13, 15%) displayed positive axillary lymph nodes. At the microscopic level, the presence of intracellular and extracellular secretory material was the most remarkable feature. Most cases showed mild dysplasia cytologically. All cases were negative for estrogen receptor, progesterone receptor and HER2. The expression rate of the basal-like marker (CK5/6 or epidermal growth factor receptor) was 87% (13 of 15). The basal-like phenotype was identified in 13 cases (87%). Follow-up time ranged from 10 to 55 months (median, 19 months). None of the cases had evidence of recurrence and metastasis. Our study reveals that secretory breast carcinoma is a distinct subset of invasive breast carcinoma, with expression of basal-like markers. It should be noted that secretory breast carcinoma is different from conventional basal-like breast carcinomas. Future studies are required to further understand the prognostic significance of the basal-like markers expression in secretory breast carcinomas.

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Section: Discussionmentioning

confidence: 99%

Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature

et al. 2012

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“…This cancer was originally described as juvenile carcinoma and thought to occur exclusively in children [16]. It was subsequently recognized in adults (accounting for two thirds of cases [37,45,104]) and renamed secretory carcinoma [44].…”

Section: Secretory Breast Cancermentioning

confidence: 99%

“…It was subsequently recognized in adults (accounting for two thirds of cases [37,45,104]) and renamed secretory carcinoma [44]. It represents 0.15% [16] of all breast cancers and 0.2% of male breast cancers [23]. The median age is 25-40 years [37][38][39], but it occurs earlier in males, at a median age of 17 years [23].…”

Section: Secretory Breast Cancermentioning

confidence: 99%

“…There is some controversy about the optimal surgical approach [38]. Local recurrences occurred in 33% of cases treated with breast-conserving surgery in one series (n ϭ 12) [75], and some authors advocate mastectomy [38,39,45,78,106] with lymph node sampling [16,38,45,107] as the primary surgical approach. Alternatively, it may be possible to consider breast-conserving surgery [23,37,45,107,108] provided that there are generous margins [23,45].…”

Section: Secretory Breast Cancermentioning

confidence: 99%

“…Proportion of breast cancers 0.1% [1][2][3] 0.4% [4,5] 0.1 %-0.6% [1,6,7] 0.2%-0.6% [1,[8][9][10] Ͻ0.1% [11][12][13] 0.7% [1,14,15] 0.15% [16] Male incidence Case reports [2,[17][18][19] with aggressive disease in two cases [2,19], an unremarkable clinical course in a third [18], and limited data in a series [17] No male cases noted Rare male cases have been reported [20] No male cases noted Only female cases [21] 3.5% of cases are male [22] 0.2% of male breast cancers [23]; occurs in both genders in children, but more common in girls [24,25] Age, yrs Median, 58-66 [2,3,17,26,27] Mean, 52-61 [4,28,29] Median, 54-63 [1 ,6] Median, 47-61 [1, 8-10, 30- [48,49] May arise from preexisting benign apocrine epithelium [50]; microscopically cells have abundant foamy to granular eosinophilic cytoplasm and round nuclei with prominent nucleoli …”

Section: Secretory Breast Cancermentioning

confidence: 99%

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Management of Unusual Histological Types of Breast Cancer

et al. 2012

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There is increased understanding of the heterogeneity of breast tumors, with greater emphasis now being placed on histological and molecular profiles and, in particular, their implications for prognosis and therapy. This review addresses breast cancers of unusual histological subtype with an approximate incidence <1%. Given the rarity of these tumors, the literature contains primarily case reports, small series, and population-based studies. Data are heterogeneous and almost entirely retrospective, frequently gathered over long time periods, in the context of changing pathological techniques and reporting. In addition, our understanding of the disease biology and therapeutic context has also evolved significantly over this time. There is often limited information about the specific therapies used and the rationale for choosing such an approach. Meaningful comparisons of treatment modalities are not feasible and it is not possible to define management guidelines. Instead, this review correlates the available information to give an impression of how each subgroup behaves-of the favored surgical technique, responses to therapy, and prognosis-as well as the emerging molecular data, highlighting new research areas for potential target in clinical trials. Each tumor subtype described represents a small but real cohort of patients with breast cancer, and although inferences may be made from this review, we are mindful of the paucity of data. The management of each patient must be considered in the context of their unique clinical presentation and correlated with the evidence-based principles that apply to more common breast cancer histologies. The Oncologist 2012;17:1135-1145

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Rare Breast Carcinomas

Dabbs

2017

Breast Pathology

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Long-term recurrence of secretory breast carcinoma with metastatic sentinel lymph nodes

Abstract: We present the clinical, radiological and pathological findings that led to the diagnosis.

Cited by 18 publications

References 11 publications

Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature

Secretory breast carcinoma: a clinicopathological and immunophenotypic study of 15 cases with a review of the literature

Management of Unusual Histological Types of Breast Cancer

Rare Breast Carcinomas

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