Long‐term remission of recalcitrant tumour‐stage mycosis fungoides following chemotherapy with pegylated liposomal doxorubicin

Abstract

Advanced stage mycosis fungoides (MF) generally has a poor prognosis, and currently there is no standard treatment available. Here we report the case of a young woman with recalcitrant tumour-stage MF (T3, stage IIb) whose disease was unresponsive to several therapeutic modalities, but who has showed sustained clinical response to pegylated liposomal doxorubucin. No severe infectious complications have been observed. The use of this drug in tumour-stage MF should be investigated further.

Pegylated liposomal doxorubicin in the treatment of primary cutaneous T-cell lymphomas

“…Stage was not found to be significantly associated with PFS. This study confirms previous reports [5][6][7] which demonstrate that PegDoxo is a well tolerated, safe and effective drug in the treatment of advanced and relapsed CTCLs, often refractory to standard therapies. Adverse events were observed in 26% patients, yet grade III-IV in only 11%.…”

“…4 Experience with PegDoxo in this group of patients is encouraging but still limited to studies of single cases of groups of a maximum of 34 patients in the largest series. [5][6][7] This led therefore to the present prospective study on advanced, relapsed and refractory primary CTCLs using Peg-Doxo as single agent. Results are compared with previous experiences with this drug and other chemotherapeutic options reported in literature.…”

Prospective Multicenter Study of Pegylated Liposomal Doxorubicin Treatment in Patients With Advanced or Refractory Mycosis Fungoides or Sézary Syndrome

“…In addition to these few studies assessing the efficacy of pegylated liposomal doxorubicin in the treatment of CTCL, Tsatalas et al 23 reported a long-term complete clinical response to pegylated liposomal doxorubicin in 1 case of resistant tumor-stage MF. Also, Prince el al 24 reported 1 case of stage IB MF and 1 of SS, both previously refractory to intravenous chemotherapy, in which the disease progressed during treatment with pegylated liposomal doxorubicin.…”

Pegylated Liposomal Doxorubicin in the Treatment of Mycosis Fungoides

“…The efficacy of LD in the treatment of MF has been described in one retrospective multicentre study (6) two single-centre studies (7,8) and two case reports (9,10). The majority of studies have reported high efficacy of LD monotherapy in patients with MF (4-7), although this has been questioned by others (10).…”