Long-term renal and overall survival of critically ill patients with acute renal injury who received continuous renal replacement therapy

Wu, Lingping; Zhang, Ping; Yang, Yi; Jiang, Hua; He, Yongchun; Xu, Chunping; Yan, Huijuan; Guo, Qi; Luo, Qun; Chen, Jianghua

doi:10.1080/0886022x.2017.1398667

Cited by 17 publications

(20 citation statements)

References 51 publications

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“…Ling ping et al conclude that sepsis-related AKI and using vasopressors were independent risk factors to increase patients' mortality [20]. Dopamine and norepinephrine are two kinds of common vasopressors widely used in curing all kinds of shocks.…”

Section: Discussionmentioning

confidence: 99%

CRRT in patients with HIV/AIDS

Guo

Liu

et al. 2020

Preprint

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Background: AKI is a common complication among human immunodeficiency virus (HIV)--infecting patients and resulting in increased morbidity and mortality. CRRT is a useful method and instrument in critically ill patients with fluid overload and metabolic disarray, especially in those who are unable to tolerate the intermittent hemodialysis. However, the epidemiology, influence factors of CRRT and mortality in patients with HIV/AIDS are still unclear in China. This study aims to study the HIV-infected patients admitted in ICU and explore the influence factors correlated with CRRT and prognosis.Methods: We performed a retrospective case-control study, in ICU of Beijing Ditan Hospital Capital Medical University, which is a top three hospital majoring in infectious diseases. From June 1,2005 to May 31,2017, 225 cases were enrolled in this research eventually.Results: 122(54.2%) patients were diagnosed with AKI during their stay in ICU, the number and percentage of AKI stage 1/2/3 were respectively 38(31.1%)/23(18.9%)/61(50%). 26.2% of AKI patients received CRRT during the stay of ICU. 56.25% CRRT patients died in ICU. The 28-day mortality was 62.5%, and the 90-day mortality was 75%. By multivariate logistics analysis, it showed that the use of vasoactive agents (OR=174.31,95% CI 1.743-65.271, p=0.018), diagnosis of PCP(OR=27.136,95% CI 1.855-397.066, p=0.016) and longer duration of CRRT (OR=1.034,95% CI 1.004-1.065, p=0.028) were independent risk factors for predicting patients’ death of CRRT in ICU. The Cox Analysis for the cumulative survival of AKI 3 patients between the CRRT and non-CRRT groups shows no significant differences (p =0.309).Conclusions: The incidence of AKI was 54.2% in HIV-infected patients admitted to the ICU, and about 26.2% AKI patients received CRRT during the stay of ICU.56.25%CRRT patients died in ICU. The 28-day mortality was 62.5%, and the 90-day mortality was 75%. The use of vasoactive agents, diagnosis of PCP were independent risk factors for predicting patients’ death of CRRT in ICU. The cumulative survival of AKI 3 patients between CRRT and non-CRRT groups shows no significant differences.

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Section: Discussionmentioning

confidence: 99%

CRRT in patients with HIV/AIDS

Guo

Liu

et al. 2020

Preprint

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“…There several studies that had shown that the following factors: age, platelet count, APACHE II score, serum creatinine level, a urine output of <0.05 mL/kg/h the first day, eGFR <45 mL/min, et al were associated with the prognosis of patients with AKI undergoing CRRT [18,19]. Moreover, there was study that reported that BMI was a risk for AKI, but was not associated with prognosis of the patients with sepsis treated with CRRT [20].…”

Section: Discussionmentioning

confidence: 99%

Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy

et al. 2019

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Background: Acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT) is a fatal and common clinical disorder in critically ill patients. Recent studies have shown that the relationship between BMI and the outcome of patients with AKI undergoing CRRT is conflicting. Methods: A retrospective cohort study based on data reuse. Univariate analysis, multi-factor regression analysis and subgroup analyses were used to explore the association of the BMI with the 28-days mortality risk in patients with AKI undergoing CRRT. Results: From January 2009 to September 2016, a total of 1120 cases met the inclusion criteria and were enrolled in this study. The univariate analysis showed that BMI was associated with 28-days mortality of patients with AKI undergoing CRRT, its HR value was 0.98 (0.96, 0.99). The multi-factor regression analysis showed that BMI was not associated with 28-days mortality of patients with AKI undergoing CRRT in the four models, the adjusted HR value of four models were 1.00 (0.96, 1.04), 1.01 (0.97, 1.04), 1.00 (0.96, 1.04) and 1.00 (0.96, 1.04), respectively. The subgroups analyses showed that the BMI was a risk factor of the 28-days mortality in patients with AKI undergoing CRRT when GFR !30 mL/min, its HR value was 1.04 (1.01, 1.09). Conclusion: Higher BMI was not a protective risk of 28-day mortality in patients with AKI undergoing CRRT. Especially, when GFR !30 mL/min, higher BMI increased the risk of the 28-day mortality rate in patients with AKI undergoing CRRT.

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“…Nephrology in the acute care setting is moving into an era of cooperation and interaction between several disciplines to address the complex needs stemming from the patients' multi-faceted problems. We should remember that in most settings, renal replacement therapy in the Intensive Care Units is still associated with at least 50% in mortality rate [10,[16][17][18] obviously, the current status quo of practice (and knowledge) is insufficient and the one thing that cannot be justified is inertia. To mention just a few examples, there is exciting literature emerging on fluid overload and volume determination in critically ill patients with acute kidney injury (AKI) [19][20][21][22], the impact of other organ failures (liver, heart) in AKI [23], on peritoneal dialysis as a viable alternative for continuous renal replacement therapy [24,25] and on the uniqueness of medication dosing in those with critical illness receiving renal replacement therapy [26,27].…”

Section: Greetings To the Readersmentioning

confidence: 99%

“…Our impact factor is currently standing at 1.44 and we look forward to attracting exciting papers on a wealth of issues but focus predominantly on AKI and aspects of critical care nephrology [17,28,29]. None of us went into Medicine hoping to find a boring job, and academic writingso it seems to so many of usis akin to a child's birth: it is immensely joyous and exhilarating to bring something into this world, which never existed before.…”

Section: Greetings To the Readersmentioning

confidence: 99%

Greetings to the readers

Fülöp

2019

Renal Failure

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Long-term renal and overall survival of critically ill patients with acute renal injury who received continuous renal replacement therapy

Cited by 17 publications

References 51 publications

CRRT in patients with HIV/AIDS

CRRT in patients with HIV/AIDS

Higher body mass index is not a protective risk factor for 28-days mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy

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