Long-Term Respiratory Morbidity Among Children With Acute Respiratory Failure: Much More to Discover

Kavitha, T; Angurana, Suresh Kumar

doi:10.1097/ccm.0000000000004592

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…The increased airflow resistance stems from the narrower diameter of their airways. Resistance increases inversely with the fourth power of the airway radius ( 11 ). A minor change in the diameter of the airway can significantly increase resistance and drastically reduce airflow.…”

Section: Discussionmentioning

confidence: 99%

Analysis of risk factors for acute attacks complicated by respiratory failure in children with asthma

Han,

Jiao,

Yin

et al. 2024

Front. Pediatr.

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ObjectiveTo describe the proportion and clinical characteristics of hospitalized children with acute asthma attacks complicated by respiratory failure and to analyze the risk factors.MethodsThis retrospective study analyzed hospital admissions of children and adolescents with acute asthma attacks between January 2016 and December 2021. Inclusion criteria were used to identify eligible cases, and demographic information and disease characteristics were collected. Patients were categorized into respiratory failure group and the other group based on the result of artery blood gas analysis. Multivariate logistic regression was utilized to investigate the risk factors associated with respiratory failure resulting from acute asthma attacks. The data were analyzed using SPSS 22.0, and significance was considered at P < 0.05.ResultsOur research involved 225 participants, with 18.7% diagnosed with respiratory failure. The respiratory failure group was found to be younger and have higher percentage of male, while birth weight, nationality, and type of residence did not differ between the two groups. In the respiratory failure group, a significant difference was observed in emergency hospitalization, ICU treatment, severe to critical attack, dyspnea and allergy history. The two groups did not differ in admission season, first asthma diagnosis, respiratory infection and comorbidity. The respiratory failure group exhibited a higher proportion of atopy-only asthma and a lower proportion of T2-high asthma. The eosinophil count, and eosinophil percentage were lower in the respiratory failure group, while neutrophil count was higher. Having a history of allergies (OR = 2.46, 95% CI: 1.08–5.59) and neutrophil count (OR = 1.10, 95% CI: 1.00–1.21) were the risk factors for respiratory failure in children with asthma. There also existed that the risk of respiratory failure increases with decreasing age of the children (OR = 0.85, 95% CI: 0.73–0.99).ConclusionNotably, risk factors for respiratory failure in hospitalized asthma children include age, having a history of allergies, and neutrophil count. The identification of the above factors and the implementation of timely intervention can optimize the treatment of asthma in children.

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Section: Discussionmentioning

confidence: 99%

Analysis of risk factors for acute attacks complicated by respiratory failure in children with asthma

Han,

Jiao,

Yin

et al. 2024

Front. Pediatr.

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show abstract

“…Respiratory tract infections in children can be caused by viruses (mainly rhinovirus, respiratory syncytial virus, and influenza virus) or bacteria (2,3). Respiratory tract infections in children caused by viruses or bacteria can be treated with antibiotics (often penicillin and macrolides), and bronchodilators (e.g., salbutamol), which relax bronchial smooth muscles, dilate bronchi and relieve airflow limitation (4). Corticosteroids can reduce airway hyperresponsiveness, eliminate airway inflammation, repair damaged epithelium and promote the regeneration of airway cilia.…”

Section: Introductionmentioning

confidence: 99%