Long-term response to zonisamide in patients with West syndrome

Suzuki, Yasuhiro; Imai, Kaoru S.; Toribe, Yasuhisa; Ueda, Hitoshi; Yanagihara, Kazuhiro; Shimono, Kuriko; Okinaga, Takeshi; Ono, Jiro; Nagai, Toshisaburo; Matsuoka, Taro; Tagawa, Tetsuzo; Abe, Junko; Morita, Yusuke; Fujikawa, Yasuhiro; Arai, Hidee; Mano, Toshiyuki; Okada, Shinichi

doi:10.1212/wnl.58.10.1556

Cited by 31 publications

(16 citation statements)

References 7 publications

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“…White cell number must be monitored. Good and excellent results are obtained either on spasms and/or hypsarrhythmia [113-115]. …”

Section: Treatmentmentioning

confidence: 99%

Infantile spasms: review of the literature and personal experience

Fois

2010

Ital J Pediatr

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This epileptic disorder has become a classic topic for neuropediatricians and the interest is documented by the large number of publications on this subject.The relative frequency among the epileptic syndromes is an another reason why not only neuropediatricians but also general pediatricians must be fully informed about diagnostic, clinical, imaging and genetic aspects.Early diagnosis is of paramount importance in order to obtain even complete results in patients with so called idiopathic situations. A number of problems are still to be solved. There is no agreement on the type and the schedule of treatment. A common denominator about this problem is not jet available even if some advances in this regard have been accomplished. Of paramount importance is an accurate clinical and laboratory examination as a prerequisite regarding prognosis and results of therapy in every single case.However, even if more than 170 years have elapsed since the first communication of dr. West on the peculiar syndrome that his child was suffering of, the interest of scientists on this subject has now been enriched and rewarded.

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“…White cell number must be monitored. Good and excellent results are obtained either on spasms and/or hypsarrhythmia [113-115]. …”

Section: Treatmentmentioning

confidence: 99%

Infantile spasms: review of the literature and personal experience

Fois

2010

Ital J Pediatr

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“…In another study, the long-term effectiveness of zonisamide was evaluated in 11 patients with West syndrome (7 symptomatic) who had cessation of spasms with zonisamide monotherapy. During the follow-up period (24 to 79 months), this response was maintained in 7 patients (relapse rate = 36%) 74. Recently, 6 of 23 (26%) patients with symptomatic infantile spasms became spasm-free on zonisamide 75…”

Section: Zonisamidementioning

confidence: 96%

Current trends in the treatment of infantile spasms

Tsao¹

2009

NDT

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Infantile spasms are an epilepsy syndrome with distinctive features, including age onset during infancy, characteristic epileptic spasms, and specific electroencephalographic patterns (interictal hypsarrhythmia and ictal voltage suppression). Adrenocorticotropic hormone (ACTH) was first employed to treat infantile spasms in 1958, and since then it has been tried in prospective and retrospective studies for infantile spasms. Oral corticosteroids were also used in a few studies for infantile spasms. Variable success in cessation of infantile spasms and normalization of electroencephalograms was demonstrated. However, frequent significant adverse effects are associated with ACTH and oral corticosteroids. Vigabatrin has been used since the 1990s, and shown to be successful in resolution of infantile spasms, especially for infantile spasms associated with tuberous sclerosis. It is associated with visual field constriction, which is often asymptomatic and requires perimetric visual field study to identify. When ACTH, oral corticosteroids, and vigabatrin fail to induce cessation of infantile spasms, other alternative treatments include valproic acid, nitrazepam, pyridoxine, topiramate, zonisamide, lamotrigine, levetiracetam, felbamate, ganaxolone, liposteroid, thyrotropin-releasing hormone, intravenous immunoglobulin and a ketogenic diet. Rarely, infantile spasms in association with biotinidase deficiency, phenylketonuria, and pyridoxine-dependent seizures are successfully treated with biotin, a low phenylalanine diet, and pyridoxine, respectively. For medically intractable infantile spasms, some properly selected patients may have complete cessation of infantile spasms with appropriate surgical treatments.

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“…Suzuki et al (2002) оценивали эффективность длительной терапии у 11 пациентов с синдромом Ве-ста (из них 7 -симптоматических случаев), у которых было отмечено прекращение эпилептических спазмов на монотерапии зонисамидом. За период катамнести-ческого наблюдения (от 24 до 79 мес, в среднем -53 мес) данный терапевтический ответ сохранялся у 7 пациентов (3 -симптоматические случаи синдро-ма Веста, частота рецидивов -36 %), включая 2 детей, у которых зонисамид был в дальнейшем отменен.…”

Section: эффективность зонисамида в лечении эпилепсииunclassified

“…Результаты исследования показали, что зониса-мид может быть эффективен в лечении синдрома Веста и хорошо переносится у этой категории паци-ентов [87].…”

Section: эффективность зонисамида в лечении эпилепсииunclassified

Zonisamide (Zonegran) in the Treatment of Epilepsy in Adults and Children (A Review and Clinical Case)

Мухин¹,

Пылаева²

2015

Rus. ž. det. nevrol.

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Long-term response to zonisamide in patients with West syndrome

Cited by 31 publications

References 7 publications

Infantile spasms: review of the literature and personal experience

Infantile spasms: review of the literature and personal experience

Current trends in the treatment of infantile spasms

Zonisamide (Zonegran) in the Treatment of Epilepsy in Adults and Children (A Review and Clinical Case)

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