“…Nevertheless, although ACDFP was suggested to confer excellent immediate stability making any posterior element instability clinically insignificant [85], early changes in construct geometry and mechanical failures occur and promote a debate regarding the use of anterior, posterior or combined stabilization for patients with marked instability [29]. Using ACDFP, the incidence of loss of alignment has been reported as 13-19% [47, 54], the need for supplemental posterior stabilization as 10-21% [20,92] and revision rates average of 6.5% [10,11,20,40,41,47,51,55,59,77,82,85,95]. Early plate designs relying on NC-plate-screw interfaces were suggested to be plagued by increased mechanical failure, screw loosening and pseudoarthrosis [10,11,30,40,69,77,82,85] most notably in multilevel constructs [60].…”