T HE LESION PRODUCING THE TYPICALLY FIXED form of obstruction within the left ventricular outflow tract seemingly changes and evolves after birth. As we will discuss, patients exhibiting this characteristic exhibit some aspects of both acquired and congenital cardiac malformations. In these respects, canine subaortic stenosis is remarkably similar, especially as seen in the Newfoundland breed. Indeed, there is now a considerable literature devoted to subaortic stenosis in several mammalian species, including the cow and swine as well as the dog. 1-11 As far as the dog is concerned, the Newfoundland is but one of a number of breeds found to harbour the fascinating lesion that obstructs the left ventricular outflow tract. The lesion has also been found in boxers, rottweilers, golden retrievers, German shepherds, German shorthaired pointers, and Bouviers de Flandres. 6-11 In this review, we will discuss in detail this fixed type of subaortic stenosis as seen in the setting of an intact ventricular septum, addressing the underlying pathology, the evolving methodologies of investigation, and the results after surgical intervention. When germane, we will make comparisons with knowledge of subaortic stenosis as seen in the dog, particularly the Newfoundland. We have excluded from discussion, however, those patients with an atrioventricular septal defect in the setting of common atrioventricular junction. The Newfoundland breed The Newfoundland dog figures importantly in discussions about subaortic stenosis. The Newfoundland breed, 12,13 during the 19th century, became a status symbol for European society. Indeed, at one time this particular dog was the most popular canine import to Great Britain. The dogs themselves became instantly recognizable after Sir Edwin Landseer painted one of their numbers in 1838. The portrait was entitled "A Distinguished Member of the Humane Society" (Fig. 1). The dog in question was called Paul Pry, Landseer was paid £80 for his efforts, and the painting was eventually dedicated to the Royal Humane Society. 14,15 Historical perspective of subaortic stenosis It is the report of Norman C. Chevers, published in 1842, which is likely the earliest description of subaortic stenosis in man. 16 More than 80 years later,