Long-Term Results From the Contura Multilumen Balloon Breast Brachytherapy Catheter Phase 4 Registry Trial

Cuttino, L.W.; Arthur, Douglas W.; Vicini, Frank A.; Todor, Dorin; Julian, Thomas B.; Mukhopadhyay, Nitai D.

doi:10.1016/j.ijrobp.2014.08.341

Cited by 44 publications

(11 citation statements)

References 5 publications

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“…However, using the single-channel MammoSite carries a certain risk of dosimetric limitation resulting in limited ability to shape the radiation dose to the target volume and OAR, which may in turn result in a greater risk of healthy tissue damage. The development of multi-luminal hybrid BT devices like Contura and Savi has combined the user-friendly application of MammoSite with the dosimetric advantages of MIB [51]. These new devices provide adequate targeting of the tumor bed and better control over the radiation dose to critical structures.…”

Section: Role Of Brachytherapy In Accelerated Partial Breast Irradiationmentioning

confidence: 99%

The Role of Brachytherapy in the Treatment of Breast Cancer

Kauer-Dorner

Berger

2018

Breast Care

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Radiotherapy plays an important part in the management of breast cancer. Especially after breast-conserving surgery, external whole breast irradiation, occasionally with an additional local boost, is an integral part of breast conservation. Besides external radiation techniques, brachytherapy (BT) has long been among the treatment options, especially with regard to local boost application. With the emerging implementation of accelerated partial breast irradiation (APBI), BT in general and interstitial multi-catheter BT in particular, are gaining an increasing role in the management of a selected group of early breast cancer patients. APBI is an approach to reduce the irradiated area to the former tumor bed rather than treating the whole breast tissue in patients with a low baseline local recurrence risk. After a variety of phase I-III clinical studies, it is clearly evident that APBI will play a role in the treatment of this selected patient group. In this review, we focus on the clinical development and different available techniques of breast BT and provide a preview of prospects for its use.

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Section: Role Of Brachytherapy In Accelerated Partial Breast Irradiationmentioning

confidence: 99%

The Role of Brachytherapy in the Treatment of Breast Cancer

Kauer-Dorner

Berger

2018

Breast Care

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“…Of note, subgroup analysis from these patients suggest that lack of estrogen receptor positivity as well as tumor size were associated with increased risks of IBTR (26)(27)(28). More recent data from the Contura registry trial which involved 342 patients showed similar results with a 2.2% risk of local recurrence at 3 years and an even more favorable toxicity profile with rates of symptomatic seroma and infection of 4.4% and 8.5%, respectively (29). Multiple small, single institution studies have also reported similar results for both local recurrence and toxicity, though are collectively with short follow-up periods of 2 years or less.…”

Section: Brachytherapy-based Apbimentioning

confidence: 77%

Accelerated partial breast radiotherapy: a review of the literature and future directions

Bennion¹,

Baine²,

Granatowicz³

et al. 2018

Gland Surg

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Breast conservation therapy exemplifies the tailoring of medicine in the care of patients with cancer. Akin to improvements in surgical approaches, accelerated partial breast irradiation (APBI) tailors the treatment volume and duration to the needs of well selected patients. Here, we examine the evidence supporting APBI as well as the lessons in patient selection, dose and delivery techniques. Examination of historical techniques and their associated outcomes will support more correct patient selection and treatment delivery in an era where we await the reports of several large prospective trials.

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“…While two population‐based studies found potentially higher complication rates (subsequent mastectomy) with brachytherapy (primarily AB, 5324/6952 cases) as the PBI technique, these results should be interpreted with caution as prospective trial data have not confirmed these findings . Additionally, improvements in toxicity profiles have been seen with newer brachytherapy applicators, which allow for reduced doses to normal breast tissue, the skin and chest wall . With respect to factors associated with outcomes, data from the ASBS registry have identified smaller skin spacing, development of infection, and chemotherapy receipt to be associated with cosmetic outcomes …”

Section: Discussion/observationsmentioning

confidence: 99%

Accelerated partial breast irradiation—Redefining the treatment target for women with early stage breast cancer

Shah

Vicini

2019

Breast J

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Following breast conserving surgery, the standard of care has been to deliver adjuvant radiation therapy directed to the whole breast (WBI) over a period of 3-7 weeks.Over the past decade, increasing data have supported the concept that treatment to the whole breast may not be required in selected patients, allowing for the emergence of partial breast irradiation (PBI). Multiple randomized trials with 5-10 years of follow-up have been published documenting the safety and efficacy associated with PBI using multiple techniques. Questions that remain to be answered include (a) what is the optimal PBI technique for each clinical scenario, (b) are there additional patients that can be effectively managed with PBI approaches, and (c) are there different techniques/dose schedules that allow for further reduction in treatment duration and/or toxicities? Partial breast irradiation represents a standard approach for appropriately selected patients. PBI provides comparable clinical outcomes to WBI while allowing for a reduction in the duration treatment and the potential for reduced toxicities. Future studies may also help to better define which patients require no radiation, PBI, hypofractionated WBI or conventional WBI, based upon patient, clinical, pathologic features as well as potentially using tumor genetics. K E Y W O R D Saccelerated partial breast irradiation, brachytherapy, breast cancer, breast conserving therapy, radiation therapy, whole breast irradiation | 409 SHAH And VICInI patients, offer guidelines for patient selection and discuss potential future directions for this approach.

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Long-Term Results From the Contura Multilumen Balloon Breast Brachytherapy Catheter Phase 4 Registry Trial

Cited by 44 publications

References 5 publications

The Role of Brachytherapy in the Treatment of Breast Cancer

The Role of Brachytherapy in the Treatment of Breast Cancer

Accelerated partial breast radiotherapy: a review of the literature and future directions

Accelerated partial breast irradiation—Redefining the treatment target for women with early stage breast cancer

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