Long-Term Results of Arterial Bypass in the Femoropopliteal Region

Suzuki, Sohei; Shimizu, Masayuki; Tanaka, Masahiko; Nomura, Shosaku; Koie, H

doi:10.1007/978-1-4612-2632-1_41

Cited by 1 publication

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“…We previously reported that the most patent bypass grafts for femoropopliteal occlusive disease due to arteriosclerosis obliterans or thromboangiitis obliterans were achieved by performing in situ vein bypass using an autogenous saphenous vein, 6 and that satisfactory POD, postoperative day a Number of patent grafts / Number of dogs killed patency was achieved in femorodistal bypass surgery. 7 On the other hand, satisfactory results for long-term patency have yet to be achieved for small-caliber artificial grafts because reocclusion frequently occurs when these grafts are used for reconstruction of the infragenicular artery, or for large-caliber artificial grafts in venous reconstruction.…”

Section: Discussionmentioning

confidence: 98%

Replacement of the Canine Inferior Vena Cava with a Seeded Graft

Shimizu¹,

Suzuki²,

Takaya³

et al. 2001

Surgery Today

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The patency and microscopic findings of gelatin-coated Dacron grafts seeded with endothelial cells and implanted into the inferior vena cava of dogs was evaluated. A total of 25 mongrel dogs were divided into four experimental groups according to whether or not an antiplatelet agent was administered and a seeded or nonseeded graft was implanted. In the groups not given antiplatelet therapy that were implanted with a nonseeded graft, occlusion of the graft occurred soon after surgery. In contrast, in the majority of animals implanted with a seeded graft and given antiplatelet therapy, graft patency was evident for up to 4 weeks postoperatively. In the latter animals, scanning electron microscopy 4 weeks after surgery showed the formation of confluent endothelial-like cells within 5 mm from the anastomosis, as well as insular endothelial-like cells in the central part of the graft. The simple centrifugal seeding method enables endothelial-like cells to adhere to grafts, suggesting that it may be useful in venous replacement.

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Section: Discussionmentioning

confidence: 98%