Long-term results of electrical stimulation of the lower esophageal sphincter for the treatment of gastroesophageal reflux disease

Abstract

During the long term follow-up of 12 months, LES - EST was safe and effective for the treatment of GERD. There was a significant and sustained improvement in GERD symptoms, reduction in esophageal acid exposure with elimination of daily PPI usage, and no stimulation-related adverse effects.

Perspectives of Surgery for Benign Esophageal Diseases

“…The focus is also to avoid or diminish the long-term use of PPI. These include endoscopic fundoplications [17][18][19][20], the Linx magnetic esophageal sphincter augmentation [21], and electric stimulation of the lower esophageal sphincter [22]. More data are needed in order to establish the best use for each procedure.…”

Adult GORD: advances and challenges in management

“…17 Both techniques have the advantages of being less invasive, reversible, with good side-effect profiles and initial good short-term results, but have limited long-term data. They may offer an approach for patients with co-morbid limitations to more traditional surgical techniques and those who wish to avoid the potential side-effects of antireflux surgery.…”

Strategies to improve outcomes in esophageal adenocarcinoma

“…Importantly, LES stimulation is not associated with any sensation or side effects and the stimulation can be tailored to the patient's symptoms. In an open-label study, median percentage of 24-h esophageal pH <4.0 was reduced from 10.1 (7.8-13.0) to 3.3 (1.8-6.9); p < 0.001 [35,36]. Good quality randomized trials with appropriate follow-up are now required to determine the efficacy of these devices for GERD treatment, before considering neoplasia prevention.…”