During the past decades, numerous hysteroscopic ablation techniques have been developed for the treatment of menorrhagia, all conferring relatively comparable success rates and low complication incidences. We here report an unusual, adverse, post-operative, complication of the Vesta thermoregulated radiofrequency endometrial ablation system in a 34-year-old nulliparous woman with dysfunctional uterine bleeding. Fourteen days after the procedure she presented with acute abdominal pain. At laparotomy, a small bowel perforation was identified, and the entire uterus was found to be necrotic, necessitating a total hysterectomy. This is the first report of a severe complication of this endometrial ablation system in the absence of uterine perforation. We propose that minimal myometrial thickness should be taken into consideration to improve the safety of thermoregulated radiofrequency endometrial ablation.