Long-term Results of Fibrin Glue Treatment for Cryptogenic Perianal Fistulas: A Multicenter Study

Haim, Nadav; Neufeld, David; Ziv, Yehiel; Tulchinsky, Hagit; Koller, Moshe; Khaikin, Marat; Zmora, Oded

doi:10.1097/dcr.0b013e318223c894

Cited by 39 publications

(16 citation statements)

References 21 publications

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“…Initial findings were encouraging, but later papers reported long-term relapses in up to 90% of cases (28)(29)(30). They may be indicated for patients with sphincteric function impairment or high surgical risk, having in mind what may be expected though.…”

Section: Discussionmentioning

confidence: 87%

Using autologous platelet-rich plasma for the treatment of complex fistulas

Moreno-Serrano¹,

García-Díaz²,

Ferrer-Márquez³

et al. 2016

Rev Esp Enferm Dig

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Objective:This study aims to demonstrate the effectiveness and safety of autologous fibrin gel rich in platelet growth factors for the treatment of complex perianal fistulas.Material and methods: Prospective epidemiological study. Patients with complex perianal fistula or perianal fistula mere alteration of continence are included. identification of both holes and the journey, curettage of it and instillation of Vivostat PRF ® in the way it is done to observe excess material by OFE. The variables analyzed were: age, sex, use of prior Seton clinic prevalent type of fistula, postoperative complications, fistula closure and impaired quality of life using the SF-36 test (v2).Results: From January 2011 to May 2013 have involved 23 patients, 12 men and 11 women, with an average age of 49 years and a minimum follow-up of 12 months. Two dropped out. 17 patients had low transsphincteric fistulas, 2 and 2 high transsphincteric intersphincteric with impaired continence. The most common symptom is the discharge. Twelve patients had a loose seton (62%), of which nine cured. Of all the patients we have operated the success rate is 62%. No patient developed incontinence after treatment. Only two reported a worse quality of life after surgery.Conclusion: This study demonstrates that there is a clear benefit to the use of Vivostat PRF ® as a treatment for complex perianal fistulas. It is a highly reproducible technique with acceptable results and does not produce impairment of continence.

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Section: Discussionmentioning

confidence: 87%

Using autologous platelet-rich plasma for the treatment of complex fistulas

Moreno-Serrano¹,

García-Díaz²,

Ferrer-Márquez³

et al. 2016

Rev Esp Enferm Dig

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“…For higher and more complex fistulae several sphincter-preserving operations are available including fibrin glue injection, anal fistula plug insertion, mucosal advancement flap, fistulectomy or ligation of the intersphincteric fistula tract. Although short-term results of fibrin glue injections seemed promising, prospective clinical trials showed recurrence rates of 46-86% [18][19][20][21]. Anal fistula plugs showed a similar trend and larger more recent studies have shown recurrence rates of 66-83% [13,22].…”

Section: Discussionmentioning

confidence: 97%

Predictive factors for recurrence of cryptoglandular fistulae characterized by preoperative three‐dimensional endoanal ultrasound

et al. 2016

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“…Treatment options for repair and eradication of anal fistula bear the risk of postoperative faecal incontinence. Minimally invasive, sphincter‐preserving treatments minimize risk of postoperative faecal incontinence, but success rates have been low . Biological infill materials used to fill and close the fistula tract can support and promote tissue healing without damage to the sphincter muscle or surrounding tissue.…”

Section: Introductionmentioning

confidence: 99%