Long-term results of fluorescence and indigo carmine blue dye-navigated sentinel lymph node biopsy

Asaga, Sota; Tsuchiya, Ai; Ishizaka, Yoshiharu; Miyamoto, Kaisuke; Ito, Hiroki; Isaka, Hirotsugu; Chiba, Tomohiro; Imoto, Shigeru; Kamma, Hiroshi

doi:10.1007/s10147-021-01925-9

Cited by 3 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indigo carmine blue has also been used as a dye for sentinel lymph node biopsy during breast cancer surgery. The safety of indigo carmine blue injection has also been confirmed ( 7 – 10 ). The aim of our study was to evaluate our strategy in the pre-operative localization of ectopic parathyroid adenomas (EPAs), emphasizing the contribution of a dye method (i.e., indigo carmine blue injection) and an intraoperativeb PTH assay.…”

Section: Introductionmentioning

confidence: 84%

Localization of Ectopic Mediastinal Parathyroid Adenomas Using Indigo Carmine Injection for Surgical Management: A Preliminary Report

Kammori

Kanazawa

Ogata³

et al. 2022

Front. Surg.

View full text Add to dashboard Cite

An ectopic parathyroid adenoma (EPA) is a rare entity. The aim of this study was to report our experience in the preoperative localization and surgical management of EPAs. This was a multicenter retrospective study involving patients diagnosed with an EPA (three males and seven females) from January 2005 to November 2021. The clinical features, preoperative management, and surgical procedures were analyzed. A cervical neck ultrasound was performed in all patients and showed a focus in eight patients. Cervicothoracic enhanced computed tomography was performed in all patients and showed a focus in nine patients. The 99mTc-MIBI scintigraphy was performed in eight patients and showed uptake in six of them. We performed a neck dissection and thoracotomy in one patient, a thoracoscopy in one patient, surgery with a focused approach in seven patients, four of whom were injected with indigo carmine blue, and surgery with a bilateral approach in one patient. 1 h following the parathyroidectomy, the parathyroid hormone (PTH) concentration was decreased to 40–80% of the baseline value. Establishing a preoperative diagnosis of an EPA is challenging for the surgeon, despite the progress in the morphologic assessment. An intraoperative PTH assay and injection of indigo carmine have been shown to be valuable tools in the appropriate surgical management of an EPA.

show abstract

Section: Introductionmentioning

confidence: 84%

Localization of Ectopic Mediastinal Parathyroid Adenomas Using Indigo Carmine Injection for Surgical Management: A Preliminary Report

Kammori

Kanazawa

Ogata³

et al. 2022

Front. Surg.

View full text Add to dashboard Cite

show abstract

“…To study this possible mechanism, we hope to publish a graph of disease-free survival and overall survival from the 60-month follow-up of patients participating in this research soon. Asaga et al published in 2021 a study with 565 patients with an even longer follow-up of 83 months, demonstrating results with a favorable prognosis (disease-free survival of 92.4% and overall survival of 97.3% and reiterating that the ICG technique is an alternative to the use of technetium in patients with breast cancer with clinically negative armpits [ 32 ]. Wang et al [ 33 ] published, also in 2021, a study with an even larger number of patients evaluated (969) and a mean follow-up of 5.6 years (2–9.3 years) reporting only 0.64% of axillary recurrence.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the efficacy of using indocyanine green associated with fluorescence in sentinel lymph node biopsy

da Silva Sá,

Von Ah Rodrigues,

Bugalho

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Introduction Sentinel lymph node biopsy is the technique recommended for the axillary staging of patients with breast cancer in the initial stages without clinical axillary involvement. Three techniques are widely used globally to detect sentinel lymph nodes: patent blue, the radiopharmaceutical technetium 99 with gamma probe, and the combination of these two. Objectives To evaluate the sentinel lymph node detection rate with an innovative technique: indocyanine green (ICG) associated with fluorescence in breast cancer patients, and compare it with patent blue and a combination of patent blue and indocyanine green. Methods 99 patients were sequentially (not randomly) allocated into 3 arms with 33 patients submitted to sentinel lymph node techniques. One arm underwent patent blue dying, the other indocyanine green, and the third received a combination of both. The detection rates between arms were compared. Results The detection rate in identifying the sentinel lymph node was 78.8% with patent blue, 93.9% with indocyanine green, and 100% with the combination. Indocyanine green identified two sentinel nodes in 48.5% of patients; the other groups more commonly had only one node identified. The mean time to sentinel lymph node identification was 20.6 ± 10.7 SD (standard deviation) minutes among patients submitted to the patent blue dye, 8.6 ± 6.6 minutes in the indocyanine green arm, and 10 ± 8.9 minutes in the combined group (P<0.001; Student’s test). The mean surgery time was 69.4 ± 16.9; 55.1 ± 13.9; and 69.4 ± 19.3 minutes respectively (P<0.001; Student’s test). Conclusions The sentinel lymph node detection rate by fluorescence using indocyanine green was 93.9%, considered adequate. The rates using patent blue, indocyanine green, and patent blue plus indocyanine green (combined) were significantly different, and the indocyanine green alone is also acceptable, since it has a good performance in sentinel lymph node identification and it can avoid tattooing, with a 100% sentinel lymph node detection rate when combined with patent blue.

show abstract

Indocyanine Green and Methylene Blue Dye Guided Sentinel Lymph Node Biopsy in Early Breast Cancer: A Single-Center Retrospective Survival Study in 1574 Patients

Yang¹,

Dong²,

Jiang³

et al. 2023

Clinical Breast Cancer

View full text Add to dashboard Cite

Long-term results of fluorescence and indigo carmine blue dye-navigated sentinel lymph node biopsy

Cited by 3 publications

References 33 publications

Localization of Ectopic Mediastinal Parathyroid Adenomas Using Indigo Carmine Injection for Surgical Management: A Preliminary Report

Localization of Ectopic Mediastinal Parathyroid Adenomas Using Indigo Carmine Injection for Surgical Management: A Preliminary Report

Evaluation of the efficacy of using indocyanine green associated with fluorescence in sentinel lymph node biopsy

Indocyanine Green and Methylene Blue Dye Guided Sentinel Lymph Node Biopsy in Early Breast Cancer: A Single-Center Retrospective Survival Study in 1574 Patients

Contact Info

Product

Resources

About