Long-Term Results of Intraoperative Radiation Therapy for Early Breast Cancer Using a Nondedicated Linear Accelerator

Hanna, Samir Abdallah; Bevilacqua, José Luiz Barbosa; Barros, Alfredo Carlos Simões Dornellas de; Andrade, Felipe; Piato, José Roberto Morales; Pelosi, Edilson Lopes; Martella, Eduardo; Silva, João Luís Fernandes da; Carvalho, Heloísa de Andrade; Jácomo, Alfredo Luiz

doi:10.1016/j.adro.2023.101233

Cited by 2 publications

(1 citation statement)

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“…In der Subgruppenanalyse der ELIOT-Studie lag die 5‑Jahres-Rezidivrate bei Luminal-A-Histologie nach IORT bei 1,5 % (im gesamten Kollektiv bei 4,4 %; [ 2 ]). Im Rahmen der hier dargestellten Untersuchung traten im Luminal-A-Kollektiv in 4,6 % Rezidive auf [ 5 ].…”

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Die intraoperative Strahlentherapie (IORT) als mögliche Alternative zum vollständigen Verzicht auf eine adjuvante Radiotherapie nach brusterhaltender Operation bei älteren Patientinnen mit niedriger Risikokonstellation

Sonnhoff,

Blach,

Hermann

2024

Strahlenther Onkol

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Section: Kommentarunclassified

Die intraoperative Strahlentherapie (IORT) als mögliche Alternative zum vollständigen Verzicht auf eine adjuvante Radiotherapie nach brusterhaltender Operation bei älteren Patientinnen mit niedriger Risikokonstellation

Sonnhoff,

Blach,

Hermann

2024

Strahlenther Onkol

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Intraoperative radiotherapy: An alternative to whole‐breast external beam radiotherapy in the management of highly selective breast cancer: A SEER database analysis

Sun,

Lu,

Liang

et al. 2024

Cancer Medicine

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ObjectiveThis study aimed to verify if intraoperative radiotherapy (IORT) can achieve the same survival outcome as whole‐breast external beam radiotherapy (EBRT) in early breast cancer after breast‐conserving surgery (BCS), and to explore the suitable candidates that can safely receive IORT after BCS.MethodsEligible post‐BCS patients who received IORT or EBRT were included in the Surveillance, Epidemiology and End Results (SEER) database from 2010 to 2018. Risk factors that affected 5‐year overall survival (OS) or breast cancer specific survival (BCSS) were identified by Cox proportional hazards regression analysis. Clinical characteristics, OS, and BCSS were comparatively analyzed between the two treatment modalities.ResultsThe survival analysis after propensity score matching confirmed that patients who received IORT (n = 2200) had a better 5‐year OS than those who received EBRT (n = 2200) (p = 0.015). However, the two groups did not differ significantly in 5‐year BCSS (p = 0.381). This feature persisted even after multivariate analyses that took into account numerous clinical characteristics. Although there was no significant difference in BCSS between different subgroups of patients treated with IORT or EBRT, patients over 55 years of age, with T1, N0, non‐triple negative breast cancers, hormone receptor‐positive, and histologic grade II showed a better OS after receiving IORT.ConclusionIn low‐risk, early‐stage breast cancer, IORT was not inferior to EBRT considering 5‐year BCSS and OS. Considering the equivalent clinical outcome but less radiotoxicity, IORT might be a reasonable alternative to EBRT in highly selective patients undergoing BCS.

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Long-Term Results of Intraoperative Radiation Therapy for Early Breast Cancer Using a Nondedicated Linear Accelerator

Cited by 2 publications

References 38 publications

Die intraoperative Strahlentherapie (IORT) als mögliche Alternative zum vollständigen Verzicht auf eine adjuvante Radiotherapie nach brusterhaltender Operation bei älteren Patientinnen mit niedriger Risikokonstellation

Die intraoperative Strahlentherapie (IORT) als mögliche Alternative zum vollständigen Verzicht auf eine adjuvante Radiotherapie nach brusterhaltender Operation bei älteren Patientinnen mit niedriger Risikokonstellation

Intraoperative radiotherapy: An alternative to whole‐breast external beam radiotherapy in the management of highly selective breast cancer: A SEER database analysis

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