Long-term results of organ preservation in chondrosarcoma of the cricoid

Abstract

Chondrosarcoma of the larynx is rare. The posterolateral lamina of the cricoid cartilage is the site most commonly involved. Although the symptomology, radiological and histopathological diagnostic features are well known, the condition continues to be diagnosed late and recurrences after excision are common. In general, radical surgical excision can result in long-term remission, although prognosis is related to the histopathological grade of the tumor. While a conservative surgical approach in low-grade tumors is justified, unexplained hoarseness, unilateral vocal cord paralysis and dyspnea requires CT scan examination.

Laryngeal Chondrosarcoma: An Exceptional Localisation of a Not Unfrequent Bone Tumor

“…In the head and neck region, chondrosarcomas most frequently occur in the maxillary bone. It is the most frequent nonepithelial tumor in the laryngeal region, accounting for 0.07–2% of all laryngeal cancers [2–6]. …”

“…The most common hypothesis is a primary disordered ossification of the cartilages [3]. Other theories presume a status of chronic inflammation or ischemic changes in a preexisting chondroma [2, 3, 7]. Windfuhr suggests that mechanical stress might be an important causal factor since the most frequent sites (the posterior cricoid area and the infero-lateral wall of the thyroid) correspond with muscle insertions [5].…”

Cartilaginous tumors of the larynx: Endoscopic laser management using YAG/KTP

“…20 It does not metastasize but presents clinical aggressiveness. 1,6,7,10,12,14,15,[21][22][23][24][25][26] Chondrosarcomas typically affect men ranging in age from 50 to 80 years (69.7 years in our study). 5,6,12,14,21,23,[25][26][27][28] The incidence of chondrosarcoma increases with age.…”

“…If patients were older than 60 years at initial presentation, there was a negative impact on patient outcome. 1,14,23,26 The overall survival rate reported in the literature is about 92% to 95% 1,6,7,10,12,15,[21][22][23]25,26,29 with a mean follow-up of 10 years. 6,7 The 5-and 10-year disease-free survival rates reported are about 70% and 50%, respectively.…”

“…[8][9][10][11][12][13] These tumors are considered to be a low-grade neoplasm, both clinically and histologically. 14,15 Because of the indolent behavior of these tumors, the diagnosis may easily be overlooked, and symptoms may persist for many years before the correct diagnosis is made. 16,17 Surgical management is difficult, because it is necessary to find a compromise by having a low rate of recurrence with restoration of all laryngeal functions (swallowing, voice, and respiration without a tracheostomy).…”