Long-term results of radioiodine (131I) therapy in 331 patients with Graves' disease.

Kaise³

et al. 1997

Clinical Endocrinology

Self Cite

Section: Discussionsupporting

confidence: 89%

The development of transient hypothyroidism after iodine‐131 treatment in hyperthyroid patients with Graves' disease: prevalence, mechanism and prognosis

Aizawa¹,

Kaise³

et al. 1997

Clinical Endocrinology

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“…In the present study, the outcome of I3'I therapy was almost the same as we reported (Saito et al, 1980;Kaise et al, 1991) earlier. We were able to follow 73-88% of the patients in Groups 1-3.…”

Section: Dlrcur8ionsupporting

confidence: 89%

Long‐term effects of radioiodine on thyrotrophin receptor antibodies in Graves' disease

Aizawa

Kaise

et al. 1995

Clinical Endocrinology

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“…Hypothyroidism has been a problem in 131I therapy. In our previous study, the incidence of hypothyroidism was 20.7% after 10 years of 1311 therapy and 33% after 15 to 17 years after 1311 therapy [11]. Delay in controlling hyperthyroidism is another problem in patients who cannot be treated with thionamide drugs because of adverse effects.…”

Section: Discussionmentioning

confidence: 97%

Thyrotropin Receptor Antibody Activities Significantly Correlate with the Outcome of Radioiodine (131I) Therapy for Hyperthyroid Graves' Disease.

Kaise

et al. 1991

Endocrinol Japon

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The outcome of 131I therapy for 109 patients with Graves' disease was analysed according to pretreatment laboratory data including thyrotropin receptor antibody (TRAb) activities. Forty-five percent of patients became euthyroid, and 13% of patients became hypothyroid within one year after 131I therapy. Forty-two percent of patients remained hyperthyroid one year after 131I therapy. Pretreatment values for serum T4, T3, and the estimated weight of the thyroid were significantly higher in the hyperthyroid group. The mean for the TRAb index of the hyperthyroid group was significantly higher than that of the euthyroid group. Life table analysis revealed a significant effect of the TRAb index on the rate of hyperthyroidism after 3 months or later. These results appear to suggest that the TRAb index is one of the factors which influence the outcome of 131I therapy for Graves' disease.