“…Additionally, RPE/FM therapy has also been reported to reduce the need of subsequent surgical treatment (Mandall et al, 2016). However, counterclockwise maxillary rotation and clockwise mandibular rotation, which can be unfavorable for patients presenting clockwise vertical growth pattern, have been associated to RPE/FM treatment (Cordasco et al, 2014;Jamilian, Cannavale, Piancino, Eslami, & Perillo, 2016;Kiliçoglu & Kirliç, 1998;Nevzatoğlu & Küçükkeleş, 2014). Taking into account that RPE/FM is an effective and minimally invasive therapy for hypoplasic Class III patients, is relevant to determine whether unfavorable mandibular rotation effects are attributable to therapy, or are rather a continuation of previously established vertical growth pattern in these patients.…”