Long-term retention of a poorly learned saccharin aversion : Evidence for an incubation effect

Marcant, Pierre; Schmaltz, G.; Roy, J.C.; Leconte, Pierre

doi:10.1016/0376-6357(85)90098-1

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…This includes data showing incubation of CTA similar to what is observed in conditioned fear. These results show moderate LiCl-induced CTA 1-2 days after conditioning that weakens within the first week after conditioning, followed by an increase in strength thereafter (Biederman et al, 1974;Marcant et al, 1985). Notably, both studies observed strong incubation of CTA 14 days after conditioning, which corresponds to the duration of vapor exposure in the present study.…”

Section: Discussionsupporting

confidence: 77%

Attenuated incubation of ethanol-induced conditioned taste aversion in a model of dependence

Ramirez,

Przybysz,

Pitock

et al. 2023

Preprint

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Rationale: Preclinical studies report attenuated ethanol-induced conditioned taste aversion (CTA) following chronic ethanol exposure, suggesting that tolerance develops to the aversive properties of ethanol. However, these studies are confounded by pre-exposure to the unconditioned stimulus (US; ethanol), which is well known to hinder conditioning. Objectives: This study was designed to determine whether chronic ethanol exposure produces tolerance to the aversive properties of ethanol in the absence of a US pre-exposure confound. Methods: CTA was performed in adult male and female Long-Evans rats by pairing 0.1% ingested saccharin with an intraperitoneal injection of ethanol (1.5 or 2.0 g/kg) or saline. Rats were then rendered ethanol dependent using chronic intermittent ethanol (CIE) vapor exposure. Controls were exposed to room air (AIR). The effect of chronic ethanol on CTA expression and reconditioning were examined following vapor exposure. Results: Prior to vapor exposure, both sexes developed CTA to a comparable degree with 2.0 g/kg producing greater CTA than 1.5 g/kg ethanol. Following vapor exposure, AIR controls exhibited an increase in CTA magnitude compared to pre-vapor levels. This effect was absent in CIE-exposed rats. These group differences were eliminated upon re-conditioning after vapor exposure. Conclusions: These data suggest that chronic ethanol does not facilitate tolerance to the aversive properties of ethanol but rather, attenuates incubation of ethanol-induced CTA. Loss of CTA incubation suggests that CIE exposure disrupts circuits encoding aversion.

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Section: Discussionsupporting

confidence: 77%

Attenuated incubation of ethanol-induced conditioned taste aversion in a model of dependence

Ramirez,

Przybysz,

Pitock

et al. 2023

Preprint

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“…This view is consistent with the autoshaping analysis, because Pavlovian investigators have extensively documented that Pavlovian CRs are retained across long retention intervals with little or no degradation of CR performance (Mackintosh, 1974). Longterm retention of autoshaping CR performance has been reported in Pavlovian feature learning in pigeons (Nakajima, 1997), and food-getting autoshaping in carp (Aoki, 1985), as well as in other Pavlovian conditioning procedures (Coulter et al, 1976;Marcant et al, 1985;Schreurs, 1993;Solomon et al, 1995;Rosas and Alonso, 1997;Solomon et al, 1998).…”

Section: Discussionmentioning

confidence: 92%

Pairings of Ethanol Sipper With Food Induces Pavlovian Autoshaping of Ethanol Drinking in Rats: Evidence of Long-Term Retention and Effects of Sipper Duration

Tomie

Sparta

Silberman³

et al. 2002

Alcohol and Alcoholism

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These data reveal that these sipper CS-food US autoshaping procedures induce drinking in rats that is durable and negatively related to increasing CS duration. The effects of both variables are consistent with the hypothesis that drinking from the sipper CS is a Pavlovian autoshaping CR. Autoshaping of drinking in the Water group is observed despite the absence of water deprivation, and even more fluid is consumed by the Ethanol group than by the Water group. The high volumes of ethanol consumed during brief daily sessions suggest that Pavlovian autoshaping procedures may provide an animal learning model of binge drinking.

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“…But, incubation has been observed in conditioned taste aversion (Biederman, Milgram, Heighington, Stockman, & O'Neill, 1974;Marcant, Schmaltz, Roy, & Leconte, 1985).…”

Section: Discussionmentioning

confidence: 99%

US postexposure effect on conditioned flavor preference in the rat

Kawai

Nakajima

1997

Psychol Rec

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Long-term retention of a poorly learned saccharin aversion : Evidence for an incubation effect

Cited by 9 publications

References 13 publications

Attenuated incubation of ethanol-induced conditioned taste aversion in a model of dependence

Attenuated incubation of ethanol-induced conditioned taste aversion in a model of dependence

Pairings of Ethanol Sipper With Food Induces Pavlovian Autoshaping of Ethanol Drinking in Rats: Evidence of Long-Term Retention and Effects of Sipper Duration

US postexposure effect on conditioned flavor preference in the rat

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