Long-term risk of sarcoma following radiation treatment for breast cancer

Feasibility of Breast Conservation Therapy in Metachronous or Synchronous Bilateral Breast Cancer

“…51 Similarly, the incidence of radiation-induced sarcomas has been found to be very low (0.1% to 0.78%); however, the prognosis of patients who develop this malignancy is poor. [51][52][53][54][55][56] Even though the patients we studied were treated over an extended period (1958 through 1994), the locoregional management of these patients has not changed significantly. We continue to have good cosmesis, and the crude local recurrence rate following BCT was 11.6%, similar to rates reported by others.…”

Lymphangiosarcoma in congenital familial lymphedema (Milroy Disease)

“…The mean annual excess (obs-exp)/ 100000 person-years at risk during the same period/ 100000 3 was 9.92. This study suggests that patients treated by radiation for breast cancer have a risk of subsequent sarcomas that is higher than that of the general population [5].…”

Synchronous development of breast cancer and chest wall fibrosarcoma after previous mantle radiation for Hodgkin’s disease

“…Postradiation sarcomas are uncommon and have a grave prognosis [3][4][5]. Such tumours are generally aggressive and have a high potential for metastasizing and local recurrence.…”

“…Post-radiation sarcoma is an uncommon entity [3]. The cumulative incidence of sarcoma following irradiation of breast carcinoma was reported as 0.2% at 10 years [4]. To our knowledge, there are no published cases of synchronous development of chest wall fibrosarcoma and breast carcinoma after mantle radiotherapy for Hodgkin's disease.…”