2023
DOI: 10.1212/wnl.0000000000207480
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Long-term Risk of Stroke in Patients With Inflammatory Bowel Disease

Abstract: Background and Objectives:Patients with inflammatory bowel disease (IBD) are at an increased risk of thromboembolic events, but evidence on the long-term risk of stroke remains scarce. We aimed to explore whether patients with a biopsy-confirmed IBD had an increased long-term risk of stroke.Methods:This cohort included all biopsy-confirmed IBD patients in Sweden between 1969 and 2019, as well as up to five matched reference individuals per patient that were randomly selected from the general population and IBD… Show more

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Cited by 10 publications
(5 citation statements)
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“…A similar association has also been observed in a retrospective multicenter cohort study in China recently [7]. In addition, the potential association was further substantiated via some other observational studies and meta-analyses [8][9][10][11].…”
Section: Introductionsupporting
confidence: 80%
“…A similar association has also been observed in a retrospective multicenter cohort study in China recently [7]. In addition, the potential association was further substantiated via some other observational studies and meta-analyses [8][9][10][11].…”
Section: Introductionsupporting
confidence: 80%
“…All in all, compared with the article of Singh et al (23), the other three articles (20)(21)(22) increased the number of cohort studies and expanded the scope of the population, making their conclusions more credible and increasing the scope of application of the conclusions. However, compared with the previous four articles, our research has the largest number of cohort studies (n = 12) and the largest sample size (n = 4,495,055), especially by including newer cohort studies (26, [34][35][36]43) published in 2021 and 2023, and a more thorough statistical analysis was conducted (e.g., preselected subgroup analyses of the types of IBD, sex, age, race/ethnicity, and duration of follow-up were conducted, and the Egger test was used to evaluate publication bias). Although the findings of our research are in line with the previously published meta-analyses on IBD and stroke, based on these advantages, our study provides relatively strong evidence that IBD is significantly associated with an increased risk of stroke.…”
Section: Discussionmentioning
confidence: 92%
“…However, the studies we included did not uniformly adjust all confounding factors, which may make the results difficult to interpret or confound associations. Third, most of the articles included in the discussion highlighted the relationship between IBD subtypes and stroke risk, however, only two articles (35,37) discussed the relationship between IBD subtypes and stroke subtypes. There is a need for more research to confirm the specific relationship between the IBD subtype and stroke subtype.…”
Section: Discussionmentioning
confidence: 99%
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