Long-term risks of invasive cervical cancer following HPV infection: follow-up of two screening cohorts in Manchester

Gilham, Clare; Sargent, Alexandra; Crosbie, Emma J.; Peto, Julian

doi:10.1038/s41416-023-02227-9

Cited by 5 publications

(3 citation statements)

References 21 publications

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“…At perimenopausal period, the hormone secretion is reduced, the imbalance of vaginal microbiota provides conditions for cervix infection ( Laniewski et al, 2020 ). Usually, increased risk of ICC is observed 15–30 years after HPV infection ( Gilham et al, 2023 ). Since HPV33 has the highest prevalence in females aged 40–44 who developed ICC.…”

Section: Discussionmentioning

confidence: 99%

Cervical HPV infection and related diseases among 149,559 women in Fujian: an epidemiological study from 2018 to 2023

Lin,

Hong,

et al. 2024

Front. Microbiol.

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ObjectivesTo comprehensively analyze the epidemiological features of human papillomavirus (HPV) and HPV-related cervical diseases in females aged 35–64 years.MethodsA total of 149,559 samples of exfoliated cervical cells screened for HPV and related cervical lesions from January 2018 to December 2023 were enrolled. The prevalence of 15 high-risk and 6 low-risk HPV genotypes were detected, and the cervical cytology were analyzed. The impact of single and multiple HPV infections was characterized, and the effect of age was studied.ResultsThe cervix cytology was normal in 86.60% of the females, while 7.13% of the females were diagnosed with cervix inflammation, 0.60% with ASC-US, 0.22% with ASC-H, 0.72% with LSIL, 0.49% with HSIL, 0.03% with ICC. The highest median age was observed in ASC-H group with 54 years old. Females with primary school education or lower have the highest positive rates. The overall HPV prevalence was 8.60%. The relatively prevalent HPV types were HPV52, 58, 16, 39, 51. HPV16, HPV18, HPV58, HPV33 and HPV52 were the top5 predominant types in ICC patients. 17.41% females suffered from multiple HPV infection with the most frequently co-infection subtypes being HPV52, HPV58 and HPV16. The prevalence of all HPV subtypes increased with age. Multiple HPV infections accounted for a larger proportion in those aged above 55 years. The peak HPV16 prevalence was observed in ICC group in cases aged 45–49 and 55–59. The peak HPV33 prevalence was observed in younger individuals aged 40–44 who developed ICC.ConclusionMore action should be taken against HPV33 infection.

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Section: Discussionmentioning

confidence: 99%

Cervical HPV infection and related diseases among 149,559 women in Fujian: an epidemiological study from 2018 to 2023

Lin,

Hong,

et al. 2024

Front. Microbiol.

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“…Various factors, such as age ( Basoya and Anjankar, 2022 ; Yuan et al, 2023 ), obesity ( Frumovitz et al, 2014 ; Coffey et al, 2016 ; Sassenou et al, 2021 ; Bohn et al, 2022 ), hormonal imbalances ( Zidi et al, 2020 ; Iversen et al, 2021 ; Lasche et al, 2022 ), genetic predisposition ( Chandra et al, 2022 ; Liu et al, 2022b ; Yadav et al, 2023a ), and environmental exposures ( Kycler et al, 2017 ; Korsakov et al, 2022 ), have been implicated in UCC development. Recently, a growing body of evidence has highlighted viral infections, particularly the Human Papillomavirus (HPV), as a key factor in UCC pathogenesis ( Figueiredo et al, 2023 ; Gilham et al, 2023 ; Smith et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Implications of viral infections and oncogenesis in uterine cervical carcinoma etiology and pathogenesis

2023

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BackgroundUterine Cervical Carcinoma (UCC) is the most prevalent gynecological malignancy globally, with a rising incidence in recent years. Accumulating evidence indicates that specific viral infections, including human papillomavirus (HPV), Epstein-Barr virus (EBV), Hepatitis B and C viruses (HBV and HCV), and human herpesvirus (HHV), may contribute to UCC development and progression. Understanding the complex interplay between viral infections and UCC risk is crucial for developing novel preventative and therapeutic interventions.MethodsThis comprehensive review investigates the association between viral infections and UCC risk by examining the roles of various viral pathogens in UCC etiology and pathogenesis, and possible molecular mechanisms. Additionally, we evaluate current diagnostic methods and potential therapeutic strategies targeting viral infections for UCC prevention or treatment.ResultsThe prevention of UCC has been significantly advanced by the emergence of self-sampling for HPV testing as a crucial tool, allowing for early detection and intervention. However, an essential challenge in UCC prevention lies in understanding how HPV and other viral coinfections, including EBV, HBV, HCV, HHV, HIV, or their concurrent presence, may potentially contribute to UCC development. The molecular mechanisms implicated in the association between viral infections and cervical cancer development include: (1) interference of viral oncogenes with cellular regulatory proteins, resulting in uncontrolled cell proliferation and malignant transformation; (2) inactivation of tumor suppressor genes by viral proteins; (3) evasion of host immune responses by viruses; (4) induction of a persistent inflammatory response, contributing to a tumor-promoting microenvironment; (5) epigenetic modifications that lead to aberrant gene expression; (6) stimulation of angiogenesis by viruses; and (7) activation of telomerase by viral proteins, leading to cellular immortalization. Additionally, viral coinfections can also enhance oncogenic potential through synergistic interactions between viral oncoproteins, employ immune evasion strategies, contribute to chronic inflammation, modulate host cellular signaling pathways, and induce epigenetic alterations, ultimately leading to cervical carcinogenesis.ConclusionRecognizing the implications of viral oncogenes in UCC etiology and pathogenesis is vital for addressing the escalating burden of UCC. Developing innovative preventative and therapeutic interventions requires a thorough understanding of the intricate relationship between viral infections and UCC risk.

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“…At perimenopausal period, the hormone secretion is reduced, the imbalance of vaginal microbiota provides conditions for cervix infection (Laniewski et al, 2020). Usually, increased risk of ICC is observed 15-30 years after HPV infection (Gilham et al, 2023). Since HPV33 has the highest prevalence in females aged 40-44 who developed ICC.…”

Section: Discussionmentioning

confidence: 99%

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Long-term risks of invasive cervical cancer following HPV infection: follow-up of two screening cohorts in Manchester

Cited by 5 publications

References 21 publications

Cervical HPV infection and related diseases among 149,559 women in Fujian: an epidemiological study from 2018 to 2023

Cervical HPV infection and related diseases among 149,559 women in Fujian: an epidemiological study from 2018 to 2023

Implications of viral infections and oncogenesis in uterine cervical carcinoma etiology and pathogenesis

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