Long-Term Safety and Stability of Gold Coil Fiducial Markers in Non-Small-Cell Lung Cancer Image-Guided Radiotherapy

Reshko, Leonid B.; Shepherd, Ray W.; Weiss, Elisabeth

doi:10.15406/ijrrt.2017.03.00049

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Previous studies of liquid markers in thoracic RT have showed limitations in radio-opacity [16] , [17] or have limited data on stability throughout the RT course [18] . Furthermore, data on the post-treatment stability (migration) of fiducial markers in lungcancer patients has only been sparsely reported [6] , [19] .…”

Section: Introductionmentioning

confidence: 99%

Long term safety and visibility of a novel liquid fiducial marker for use in image guided radiotherapy of non-small cell lung cancer

Blanck

Rydhög

Larsen

et al. 2018

Clinical and Translational Radiation Oncology

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HighlightsReport on safety and clinical feasibility of a novel liquid fiducial marker for radiotherapy in lung cancer patients.No serious safety or toxicity issues related to implantation procedure, radiotherapy or follow-up period.Visible in ultrasound, kV X-ray, CT and ConeBeam CT images.Slow degradation and no migration of the marker in follow up CT images.Clinically feasible for use as a fiducial marker in radiotherapy of lung cancer patients.

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Section: Introductionmentioning

confidence: 99%

Long term safety and visibility of a novel liquid fiducial marker for use in image guided radiotherapy of non-small cell lung cancer

Blanck

Rydhög

Larsen

et al. 2018

Clinical and Translational Radiation Oncology

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“…In contrast, transbronchial FM implantation is much safer. A review of 5 studies using the transbronchial FM implantation method showed that 4 of them recorded 0% implantation-induced pneumothorax ( 14 , 15 , 29 , 30 ), and the remaining one recorded 2.3% ( 31 ). Other recent studies showed that the rate of complication is usually associated with guided transbronchial biopsies (TBBs) performed before FM implantation ( 32 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Fiducial Marker Pre-Planning for Virtual Bronchoscopic Navigation Implantation in Lung Tumour Patients Treated With CyberKnife

Lam²,

Wu³

et al. 2022

Front. Oncol.

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PurposeFor the treatment of invisible lung tumours with CyberKnife (CK), fiducial markers (FMs) were implanted as an internal surrogate under virtual bronchoscopic navigation (VBN). This research aims to study the benefits of introducing an additional procedure in assigning the optimal FM positions using a pre-procedure planning system and performing virtual simulation before implantation. The objectives were 1) to reduce the duration of the FM implantation procedure, 2) to reduce the radiation exposure in dose area product (DAP) (dGy*cm2) to patients, and 3) to increase the number of FMs implanted around the tumour.Methods and MaterialsThis study is retrospective, single-centre, and observational in nature. A total of 32 patients were divided into two groups. In Group 1, 18 patients underwent conventional VBN FM implantation. In Group 2, 14 patients underwent additional pre-procedure planning and simulation. The steps of pre-procedure planning include 1) importing CT images into the treatment planning system (Eclipse, Varian Medical Systems, Inc.) and delineating five to six FMs in their ideal virtual positions and 2) copying the FM configuration into VBN planning software (LungPoint Bronchus Medical, Inc.) for verification and simulation. Finally, the verified FMs were deployed through VBN with the guidance of the LungPoint planning software.ResultsA total of 162 FMs were implanted among 35 lesions in 32 patients aged from 37 to 92 (median = 66; 16 men and 16 women). Results showed that 1) the average FM insertion time was shortened from 41 min (SD = 2.05) to 23 min (SD = 1.25), p = 0.00; 2) the average absorbed dose of patients in DAP was decreased from 67.4 cGy*cm2 (SD = 14.48) to 25.3 cGy*cm2 (SD = 3.82), p = 0.01 (1-tailed); and 3) the average number of FMs implanted around the tumour was increased from 4.7 (SD = 0.84) to 5.6 (SD = 0.76), p = 0.00 (1-tailed).ConclusionPre-procedure planning reduces the FM implantation duration from 41.1 to 22.9 min, reduces the radiation exposure in DAP from 67.4 to 25.3 dGy*cm2, and increases the number of FMs inserted around the tumour from 4.7 to 5.6.

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Long-Term Safety and Stability of Gold Coil Fiducial Markers in Non-Small-Cell Lung Cancer Image-Guided Radiotherapy

Abstract: Background: Fiducial markers aid in tumor localization during radiotherapy of lung cancer. We investigated the long-term stability and safety of gold coil fiducial markers in non-small cell lung cancer (NSCLC) patients.

Cited by 2 publications

References 22 publications

Long term safety and visibility of a novel liquid fiducial marker for use in image guided radiotherapy of non-small cell lung cancer

Long term safety and visibility of a novel liquid fiducial marker for use in image guided radiotherapy of non-small cell lung cancer

Clinical Evaluation of Fiducial Marker Pre-Planning for Virtual Bronchoscopic Navigation Implantation in Lung Tumour Patients Treated With CyberKnife

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