Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial

Alcalá‐Díaz, Juan F.; Peña, Yolanda Almaden; Aranda, Enrique; Larriva, Antonio P. Arenas de; Badimón, Lina; Badimón, Juan J.; Blanco-Molina, Ángeles; Blanco-Rojo, Ruth; Bolivar-Muñoz, Julia; Caballero-Villarraso, Javier; Camargo, Antonio; Chica, Javier Emílio Lazo; Corina, Andreea; Criado-García, Juan; Cruz‐Teno, Cristina; Daponte-Codina, Antonio; Galván, Eduardo de Teresa; Delgado‐Casado, Nieves; Delgado‐Lista, Javier; Estruch, Ramón; Fernández, Juan Marcelo; Fernández-Gandara, Carolina; Fuentes, Francisco; Fernandez-Pacheco, Sonia Garcia-Carpintero; García‐Rios, Antonio; Gómez-Delgado, Francisco; Gomez-Garduño, Angela; Gómez-Luna, Purificación; Gómez-Luna, Maria J.; González-Guardia, Lorena; Gonzalez-Requero, Ana I.; Gutiérrez-Mariscal, Francisco M.; Haro, Carmen; Jiménez-Lucena, Rosa; Jiménez-Morales, Ana I.; León-Acuña, Ana; López‐Miranda, José; López-Segura, Fernando; Marín-Hinojosa, Carmen; Alvarez, Maria E Meneses; Mesa-Luna, Dolores; Moya-Garrido, Maria N; Muñoz-Carvajal, Ignacio; Navarro-Martos, Vanessa; Ochoa, Juan J; Ordovás, José M.; Ortiz-Minuesa, Juan A; Ortiz-Morales, Ana M; Pan, Manuel; Peña-Orihuela, Patricia J.; Perez-Caballero, Ana I.; Perez-Corral, Isabel; Pérez-Jiménez, Francisco; Pérez‐Martínez, Pablo; Pi-Sunyer, Francesc X; Quintana-Navarro, Gracia M.; Ramirez-Lara, Irene; Rangel‐Zúñiga, Oriol A.; Rodríguez‐Artalejo, Fernando; Rodríguez-Cantalejo, Fernando; Romero, Miguel A.; Roncero-Ramos, Irene; Ruano-Ruiz, Juan; Castroviejo, Joaquín Ruiz de; Sánchez‐Villegas, Pablo; Lezo, José Suárez de; Lezo, Javier Suárez de; Torres-Peña, José D.; Vals-Delgado, Cristina; Valverde, Roberto; Visioli, Francesco; Yubero‐Serrano, Elena M.

doi:10.1016/s0140-6736(22)00122-2

Cited by 311 publications

(168 citation statements)

References 34 publications

Supporting

Mentioning

154

Contrasting

Unclassified

Order By: Relevance

“…Yubero–Serrano et al reported on evidence from the CORonary Diet Intervention with Olive oil and cardiovascular PREVention (CORDIOPREV) study (NCT00924937) [ 84 , 85 ]. CORDIOPREV was a prospective trial in a cohort of 1002 coronary heart disease (CHD) patients, primarily comparing two healthy dietary patterns: The MedDiet and the low-fat diet.…”

Section: Evidence From the Clinical Trialsmentioning

confidence: 99%

The Mediterranean Diet: An Update of the Clinical Trials

et al. 2022

View full text Add to dashboard Cite

The Mediterranean Diet (MedDiet) is a term used to identify a dietary pattern originating from the unique multi-millennial interplay between natural food resources and the eating practices of people living in the Mediterranean basin. Scientific evidence has described the healthy properties of the MedDiet and its beneficial role in several pathological conditions. Nevertheless, current socio-economic trends have moved people away from this healthy lifestyle. Thus, clinical and biological evidence supporting the benefits of the MedDiet is needed to overcome these limitations. Clinical nutrition research examines the effects of dietary interventions on biological or health-related outcomes in a determined study population. The evidence produced by these studies is useful for dietary guidance and public health messaging. We provided an update of the clinical trials registered on the database clinicaltrials.gov evaluating the effects of the MedDiet on health and specific diseases. Our findings revealed an increased number of clinical trials in the last decade and found that most disease-related studies focused on cardiovascular diseases, metabolic diseases, and cancer. The majority of MedDiet’s beneficial effects could be primarily related to its anti-inflammatory and anti-oxidant properties as well as the effectiveness of this dietary pattern in controlling waist circumference and obesity. Moreover, strict and long-lasting adherence to the MedDiet as well as the beneficial effects of specific components (e.g., olive oil or its polyphenols) seem to emerge as useful insights for interventional improvements. These findings present further insights into the MedDiet’s resources and how it could strengthen overall public health.

show abstract

Section: Evidence From the Clinical Trialsmentioning

confidence: 99%

The Mediterranean Diet: An Update of the Clinical Trials

et al. 2022

View full text Add to dashboard Cite

show abstract

“… 263 Particularly, MD alters the microbial compositions and function to benefit cardiometabolic homoeostasis, 264 , 265 and reduce diverse cardiovascular events like atherosclerosis to prevent cardiovascular disease. 266 , 267 Altogether, dietary interventions partially mediate these cardiovascular complications.…”

Section: Dietary Intervention In Tissue Health and Diseasementioning

confidence: 99%

Dietary regulation in health and disease

Gao

et al. 2022

Sig Transduct Target Ther

View full text Add to dashboard Cite

Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan and delaying ageing in various species such as yeast, drosophila, rodent, primate and human. It emerges to develop the precision-nutrition therapeutics to slow age-related biological processes and treat diverse diseases. However, the nutritive advantages frequently diversify among individuals as well as organs and tissues, which brings challenges in this field. In this review, we summarize the different forms of dietary interventions extensively prescribed for healthspan improvement and disease treatment in pre-clinical or clinical. We discuss the nutrient-mediated mechanisms including metabolic regulators, nutritive metabolism pathways, epigenetic mechanisms and circadian clocks. Comparably, we describe diet-responsive effectors by which dietary interventions influence the endocrinic, immunological, microbial and neural states responsible for improving health and preventing multiple diseases in humans. Furthermore, we expatiate diverse patterns of dietotheroapies, including different fasting, calorie-restricted diet, ketogenic diet, high-fibre diet, plants-based diet, protein restriction diet or diet with specific reduction in amino acids or microelements, potentially affecting the health and morbid states. Altogether, we emphasize the profound nutritional therapy, and highlight the crosstalk among explored mechanisms and critical factors to develop individualized therapeutic approaches and predictors.

show abstract

“…Aligned to these clinical outcomes, the Mediterranean diet significantly decreased markers of atherosclerosis progression compared to the low-fat diet, including reduction in intima-media thickness of both common carotid arteries and carotid plaque height [23]. Importantly, in this secondary prevention cohort who were receiving standard medical treatment, there was no effect of dietary intervention on cholesterol, blood glucose levels or weight [22 ▪▪ ], which postulates that the Mediterranean diet influenced atherosclerosis through other mechanisms such as reducing circulating inflammation [24].…”

Section: Introductionmentioning

confidence: 76%

“…Recently published data from a landmark secondary prevention single-blinded randomized controlled trial, the CORDIOPREV study, supports this. In 1002 people with existing coronary heart disease, it was demonstrated that adjunct to usual treatment, Mediterranean diet intervention significantly reduced risk of composite major cardiovascular events compared with low-fat diet after 7 years (hazard ratio [HR] 0.734 (0.55–0.97) in the total cohort and HR 0.67 (0.49–0.92) in men) [22 ▪▪ ]. Aligned to these clinical outcomes, the Mediterranean diet significantly decreased markers of atherosclerosis progression compared to the low-fat diet, including reduction in intima-media thickness of both common carotid arteries and carotid plaque height [23].…”

Section: Introductionmentioning

confidence: 99%

The anti-inflammatory effects of a Mediterranean diet: a review

Itsiopoulos

Mayr

Thomas

2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

View full text Add to dashboard Cite

Purpose of reviewChronic noncommunicable diseases remain the leading cause of morbidity and mortality worldwide and the majority are preventable with a healthy diet and lifestyle, but controversy remains as to the best approach. Greater adherence to a traditional Mediterranean diet has consistently been associated with lower morbidity and mortality from cardiovascular disease, diabetes and many cancers, and lower all-cause mortality. Despite the well known benefits on chronic disease risk there remains some scepticism as to the effects of this dietary pattern across populations outside the Mediterranean and the mechanisms of action of this traditional plant-based dietary pattern.This narrative review aims to summarize the latest evidence on the health protective effects of a traditional Mediterranean diet on chronic noncommunicable diseases, specifically focussing on the anti-inflammatory effects of this highly published dietary pattern.Recent findingsRecent high-quality evidence now supports a Mediterranean diet in secondary prevention of cardiovascular disease with impacts on atherosclerosis progression, likely through reduction of systemic inflammation and irrespective of changes in cholesterol or weight. The Mediterranean diet has a low Dietary Inflammatory Index illustrating its anti-inflammatory potential. This dietary pattern beneficially modulates the gut microbiota and immune system, including emerging evidence for efficacy against severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019). Emerging evidence shows clinicians are not routinely recommending a Mediterranean diet despite well known evidence due to barriers such as lack of training, patient materials and concerns about potential patient adherence.SummaryThe physiological mechanisms of action of this healthy diet pattern are becoming better understood to be multisystem and involving the gut. Larger controlled trials investigating mechanistic effects in broader non-Mediterranean populations are warranted. Although reflected in therapeutic guidelines for chronic disease management worldwide there are individual, clinical practice and health system barriers to its implementation that need a multisectoral approach to address.

show abstract

Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial

Cited by 311 publications

References 34 publications

The Mediterranean Diet: An Update of the Clinical Trials

The Mediterranean Diet: An Update of the Clinical Trials

Dietary regulation in health and disease

The anti-inflammatory effects of a Mediterranean diet: a review

Contact Info

Product

Resources

About