Long-Term Secular Trends in the Age at Menarche in Israel: A Systematic Literature Review and Pooled Analysis

Flash-Luzzatti, Shira; Weil, Clara; Shalev, Varda; Oron, Tal; Chodick, Gabriel

doi:10.1159/000357444

Cited by 21 publications

(10 citation statements)

References 52 publications

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“…Girls who matured earlier were shorter in adulthood than girls who matured later [29]. Although we had no data on the age at pubertal onset of our cohort, after exclusion of patients with precocious puberty, age of menarche in females was similar to that of the general population [30]. The impairment of potential genetic adult height can therefore not be explained by an accelerated rate of the pubertal process, and other mechanisms must play a role.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Adolescent Obesity on Adult Height

et al. 2017

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Background: Childhood obesity is a major health concern. Excess adiposity during childhood affects growth and puberty. Our aim was to assess whether genetic adult height is compromised in adolescents with obesity. Methods: In a retrospective study of 190 obese patients followed at our Pediatric Endocrinology Institute, adult height and delta height (the difference between adult height and mid-parental height) were compared to those of 150 healthy age-matched normal-weight controls. Review of medical files yielded the relevant clinical and anthropometric data of patients, controls, and parents. Results: Of the 190 obese adolescents, 150 were morbidly obese. The median adult height of morbidly obese males was 174.3 cm, of obese males 174 cm, and of normal-weight males 176 cm (p = 0.025). Delta height of morbidly obese males was –0.5 cm, of obese males –0.8 cm, and of normal-weight males, 3 cm (p < 0.0001). The median adult height of morbidly obese females was 161.3 cm, of obese females 162.8 cm, and of normal-weight females 162 cm (p = 0.37). Delta height of morbidly obese females was –1.85 cm, of obese females –0.95 cm, and of normal-weight females 0.7 cm (p = 0.019). Impairment of potential genetic height was not associated with obesity-related comorbidities. Conclusion: Adolescents with obesity showed impairment of potential genetic adult height as compared to that of normal-weight subjects.

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Section: Discussionmentioning

confidence: 99%

The Impact of Adolescent Obesity on Adult Height

et al. 2017

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“…Of note, the females reported here had delayed puberty. The eldest sister had her menarche at the age of 17 years and the middle sister at the age of 15 years, while the mean age of menarche in Israel is about 13 years (Flash‐Luzzatti, Weil, Shalev, Oron, & Chodick, ). Hu et al () did not mention pubertal development in the 14‐year‐old affected female.…”

Section: Discussionmentioning

confidence: 99%

Homozygous mutation in PTRH2 gene causes progressive sensorineural deafness and peripheral neuropathy

Sharkia

Shalev

Zalan

et al. 2017

American J of Med Genetics Pt A

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PTRH2 is an evolutionarily highly conserved mitochondrial protein that belongs to a family of peptidyl-tRNA hydrolases. Recently, patients from two consanguineous families with mutations in the PTRH2 gene were reported. Global developmental delay associated with microcephaly, growth retardation, progressive ataxia, distal muscle weakness with ankle contractures, demyelinating sensorimotor neuropathy, and sensorineural hearing loss were present in all patients, while facial dysmorphism with widely spaced eyes, exotropia, thin upper lip, proximally placed thumbs, and deformities of the fingers and toes were present in some individuals. Here, we report a new family with three siblings affected by sensorineural hearing loss and peripheral neuropathy. Autozygosity mapping followed by exome sequencing identified a previously reported homozygous missense mutation in PTRH2 (c.254A>C; p.(Gln85Pro)). Sanger sequencing confirmed that the variant segregated with the phenotype. In contrast to the previously reported patient, the affected siblings had normal intelligence, milder microcephaly, delayed puberty, myopia, and moderate insensitivity to pain. Our findings expand the clinical phenotype and further demonstrate the clinical heterogeneity related to PTRH2 variants.

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“…72,73 Increased childhood and adolescent BMI may be associated with younger age of menarche. 74,75 Both BMI and early puberty were associated with socio-economic factors and may reflect the combined effect of genetics and environment.…”

Section: Discussionmentioning

confidence: 99%

Adolescent BMI at Northern Israel

et al. 2016

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The increasing prevalence of abnormal body mass index (BMI), mainly obesity, is becoming a significant public health problem. This cross-sectional study aimed to provide a comprehensive view of secular trends of BMI, and the associated socio-demographic variables and comorbidities among adolescents with abnormal BMI. Individuals of the study population were born mainly between 1970 and 1993, and were examined at 16 to 19 years of age during the years 1987 to 2010, at 1 conscription center in the northern district of Israel.The study population included 113,694 adolescents. Univariate and multivariable logistic regression models were used to investigate the associations between BMI categories, socio-demographic variables, and medical conditions.A downward trend in the prevalence of normal BMI among both male and female adolescents was obtained, while trends of overweight and obesity (in both genders) and underweight (only among females) rose. Socio-demographic variables such as religion, education, family-related parameters, residential environment, country of birth, and origin were all associated with different risks for abnormal BMI. Obesity was associated with higher risk for hyperlipidemia, endocrine disorders (only in males), knee disorders, and hypertension type I + II (in both genders). Overweight was associated with knee disorders (only in females). Underweight, exclusively in males, was associated with increased risk for endocrine disorders, proteinuria, and cardiac disorders. Hierarchical clustering analysis revealed the intricate relations between gender, BMI, and medical signatures. It brought to light novel clusters of diseases that were abundant among populations having above-normal BMI or underweight males. Furthermore, above-normal BMI was associated with a lower rate of cardiac anomalies and scoliosis/kyphosis, whereas being underweight was associated with a lower risk for hypertension and flat foot.This study provides a reliable and in-depth view of secular trends in height, weight, and BMI of male and female adolescents. It supports previous associations between abnormal BMI and demographic variables and comorbidities, while uncovering novel associations, mainly regarding medical signatures of each gender–BMI group. This might lead to better monitoring, early detection, prevention, and treatment of various conditions associated to abnormal BMI categories and gender groups.

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Long-Term Secular Trends in the Age at Menarche in Israel: A Systematic Literature Review and Pooled Analysis

Cited by 21 publications

References 52 publications

The Impact of Adolescent Obesity on Adult Height

The Impact of Adolescent Obesity on Adult Height

Homozygous mutation in PTRH2 gene causes progressive sensorineural deafness and peripheral neuropathy

Adolescent BMI at Northern Israel

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