Long-Term Serological Analysis and Clinical Follow-Up of Patients with Cat Scratch Disease

Metzkor-Cotter, Einat; Kletter, Yehudith; Avidor, Boaz; Varon, Merav; Golan, Yoav; Ephros, Moshe; Giladi, Michael

doi:10.1086/378738

Cited by 107 publications

(90 citation statements)

References 13 publications

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“…For example, in a study that used IgM antibodies to detect acute infections, readers needed to know the interval between blood tests for IgM antibodies so that they could judge whether some infections likely were missed because the interval between blood tests was too long. 41 In other studies where follow-up procedures differed between exposed and unexposed groups, readers might recognize substantial bias due to unequal ascertainment of events or differences in nonresponse or loss to follow-up. 42 Accordingly, we advise that researchers describe the methods used for following participants and whether those methods were the same for all participants, and that they describe the completeness of ascertainment of variables (see also item 14).…”

Section: Explanationmentioning

confidence: 99%

Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration

et al. 2007

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Much medical research is observational. The reporting of observational studies is often of insufficient quality. Poor reporting hampers the assessment of the strengths and weaknesses of a study and the generalizability of its results. Taking into account empirical evidence and theoretical considerations, a group of methodologists, researchers, and editors developed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) recommendations to improve the quality of reporting of observational studies.The STROBE Statement consists of a checklist of 22 items, which relate to the title, abstract, introduction, methods, results and discussion sections of articles. Eighteen items are common to cohort studies, case-control studies and cross-sectional studies and four are specific to each of the three study designs. The STROBE Statement provides guidance to authors about how to improve the reporting of observational studies and facilitates critical appraisal and interpretation of studies by reviewers, journal editors and readers.This explanatory and elaboration document is intended to enhance the use, understanding, and dissemination of the STROBE Statement. The meaning and rationale for each checklist item are presented. For each item, one or several published examples and, where possible, references to relevant empirical studies and methodological literature are provided. Examples of useful flow diagrams are also included. The STROBE Statement, this document, and the associated web site (http://www.strobe-statement.org) should be helpful resources to improve reporting of observational research. (Epidemiology 2007;18: 805-835) R ational health care practices require knowledge about the etiology and pathogenesis, diagnosis, prognosis and treatment of diseases. Randomized trials provide valuable evidence about treatments and other interventions. However, much of clinical or public health knowledge comes from observational research. 1 About nine of ten research papers published in clinical speciality journals describe observational research. 2,3 The STROBE StatementReporting of observational research is often not detailed and clear enough to assess the strengths and weaknesses of the investigation. 4,5 To improve the reporting of observational research, we developed a checklist of items that should be addressed: the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement (Table 1). Items relate to title, abstract, introduction, methods, results and discussion sections of articles. The STROBE Statement has recently been published in several journals. 6 Our aim is to ensure clear presentation of what was planned, done, and found in an observational study. We stress that the recommendations are not prescriptions for setting up or conducting studies, nor do they dictate methodology or mandate a uniform presentation.STROBE provides general reporting recommendations for descriptive observational studies and studies that investigate 805associations between expos...

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Section: Explanationmentioning

confidence: 99%

Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration

et al. 2007

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“…Two techniques are available to detect antibodies against BH. The immunofluorescent antibody assay (IFA) is considered more reliable and more sensitive than the enzyme-linked immunosorbent assay (EIA) (6,8). The sensitivity and specificity of immunoglobulin (Ig) G detection by IFA have been reported respectively around 88% and 97%.…”

Section: Discussionmentioning

confidence: 99%

“…The sensitivity and specificity of immunoglobulin (Ig) G detection by IFA have been reported respectively around 88% and 97%. IgM detection is slightly less sensitive and specific (respectively around 70 -90% and 87.5 -100%) (6,8). The timing is also important for the interpretation of these analyses.…”

Section: Discussionmentioning

confidence: 99%

Atypical Cat-Scratch Disease in Children: Report of Seven Presentations Ranging From Hepatosplenic Disease to Horner Syndrome

Gilliaux

Ghilain

Linden

et al. 2016

Arch Pediatr Infect Dis

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Introduction: Cat scratch disease (CSD) is an infectious disease caused by the Gram-negative rod Bartonella henselae (BH). It usually leads to subacute loco-regional lymphadenitis occasionally associated with fever. In most of the cases, it resolves spontaneously within 4 -6 weeks. However, CSD has also been associated with other atypical presentations. Case Presentation: We reported a series of seven children with unusual symptoms of CSD. In particular, we described the case of a child with ptosis, miosis and enophtalmy, suggesting Horner syndrome, associated with cervical lymphadenitis. Cat scratch was mentioned in only one patient, while four of them mentioned a recent contact with cats. We reviewed and discussed the incidence of these atypical presentations of CSD as well as the therapeutic approaches recommended and the available diagnostic tools. Conclusions: This paper highlighted the need to exclude CSD in children with unexplained symptoms such as prolonged fever, hepatosplenic lesion and osteomyelitis.

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“…Further typical histopathology findings of granulomas or plump bacilli on Warthin-Starry or similar silver staining (e.g., Steiner) may not be present during the initial inflammatory phase. Additional tests, including PCR-based assays, are now commercially available through multiple laboratories and can be even more sensitive than serologic studies (Matar et al 1999, Sander et al 1999, Murakami et al 2002, Metzkor-Cotter et al 2003. PCR of tissue is specific, but sensitivity again is variable, ranging from 40% to 70%.…”

Section: Discussionmentioning

confidence: 99%

BartonellaOsteomyelitis of the Acetabulum: Case Report and Review of the Literature

Puri

Kreppel

Schlaudecker

2015

Vector-Borne and Zoonotic Diseases

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Introduction: Bartonella henselae commonly involves the mononuclear phagocyte system (MPS), and its most common presentation is lymphadenitis. Rarely, it can cause isolated osteomyelitis. We present a case of a 3 year old with constitutional symptoms and new onset of limp. Previously reported cases of osteomyelitis due to B. henselae are also reviewed here, keeping the index case in mind. Methods: We conducted a Medline search using MeSH subject headings Bartonella and osteomyelitis, limited to humans. Results: The index case is a 3-year-old female who had a subacute presentation with new-onset leg pain and fever. Subsequent imaging demonstrated osteomyelitis of the acetabulum. Multiple diagnostic attempts were unsuccessful, and the patient did not respond to empiric therapy. Despite indeterminate serology, the diagnosis of Bartonella osteomyelitis was eventually confirmed by PCR on bone biopsy of the lesion. The literature search revealed 48 publications, which were reduced to 28 when limiting articles to the English language and the pediatric population. After a report of 36 pediatric cases in 2007, there have been an additional 12 pediatric cases since 1998. Generally, these patients had a subacute presentation with relatively mild constitutional symptoms. Most commonly, bone involvement occurred as osteolytic lesions of the axial skeleton. Of the total 48 cases reported, only four reported involvement of the axial skeleton. Conclusion: We present the first case, to our knowledge, of pediatric osteomyelitis of the pelvis due to B. henselae with indeterminate serologic and positive PCR results. Bartonella osteomyelitis should be included in the differential diagnosis when typical pathogens are not identified or if the patient is slow to respond to standard therapies. The sensitivity of tissue PCR for Bartonella osteomyelitis is now better than the current gold standard of serology, and new management guidelines may need to reflect this.

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Long-Term Serological Analysis and Clinical Follow-Up of Patients with Cat Scratch Disease

Cited by 107 publications

References 13 publications

Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration

Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration

Atypical Cat-Scratch Disease in Children: Report of Seven Presentations Ranging From Hepatosplenic Disease to Horner Syndrome

BartonellaOsteomyelitis of the Acetabulum: Case Report and Review of the Literature

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