Long-term side effects in irradiated patients with Hodgkin's disease

Slanina, J; Musshoff, K.; Rahner, Thomas; Stiasny, Rolf; Barmeyer, J.; Baumeister, L; Berger, WE; Dichgans, J.; Gehring, Gabriela Margraf; Grub, R.; Heite, H. J.; Hennekeuser, H. H.; Herkel, L; Krüsmann, W; Kuphal, K; Löhr, G.; Möbius, W; Roßner, R.; Schmidt-Vollmer, H.

doi:10.1016/0360-3016(77)90003-7

Cited by 106 publications

(14 citation statements)

References 20 publications

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“…All were azoospermie, but only two patients were followed for longer than 16 months. 27.5% of the men studied retrospectively [7] were either oligospermie or had a normal sperm count following similar radiation treatment and scatter dosage to the testes, but the follow-up period was longer for these latter patients suggesting that recovery of spermatogenesis may have taken place.…”

Section: Effect Of Single Dose Irradiation On Spermatogenesismentioning

confidence: 99%

Effect of Irradiation Treatment on Gonadal Function in Men Treated for Germ Cell Cancer

Shalet¹

1993

Eur Urol

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Section: Effect Of Single Dose Irradiation On Spermatogenesismentioning

confidence: 99%

Effect of Irradiation Treatment on Gonadal Function in Men Treated for Germ Cell Cancer

Shalet¹

1993

Eur Urol

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“…All were azoospermic, but only two patients were followed for longer than 16 months. Of the men studied retrospectively, 27.5% (33) were either oligospermic or had a normal sperm count following similar radiation treatment and scatter dosage to the testes, but the follow-up period was longer for these latter patients, suggesting that recovery of spermatogenesis may have taken place.…”

Section: Radiation and The Testismentioning

confidence: 99%

Effect of Radiation on the Human Reproductive System

Ogilvy-Stuart¹,

Shalet²

1993

Environmental Health Perspectives

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Irradiation may have a profound effect on reproductive function. The schedule of the delivered irradiation (total dose, number of fractions, and duration) is an important determinant ofthe radiobiological effect on the tissues involved and varies among different tissues and organs. Irradiation to the central nervous system may affect the timing of the onset of puberty, result in hyperprolactinemia, or cause gonadotropin deficiency if the hypothalamic-pituitary axis is involved in the radiation field. Direct irradiation to the testis will, in lower doses, affect the germinal epithelium: doses of irradiation greater than 0.35 Gy cause aspermia, which may be reversible. The time taken for recovery increases with larger doses; however, with doses in excess of 2 Gy aspermia may be permanent. At higher radiation doses (> 15 Gy), Leydig cell function will also be affected. In addition to radiation dose, the vulnerability ofthe testis is dependent on the age at irradiation and the pubertal status of the male. In the female, the response of the ovary to the effects of irradiation varies with age as well as dose, and separation of ovarian dysfunction into hormonal and fertility effects is not clearcut. An ovarian dose of4 Gy may cause a 30% incidence of sterility in young women, but 100% sterility in women over 40 years of age. Pelvic irradiation may also have a profound effect on the uterus, with arrested growth in the prepubertal girl, and failure of uterine expansion during pregnancy with subsequent miscarriages and premature labor.

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“…All were azoospermic but only two patients were followed for longer than 16 months (26 and 40 months). Some 27.5% of the males studied retrospectively by Slanina et al (1977) were either oligospermic or had a normal sperm count following similar radiation treatment and scatter dosage to the testes. However the follow-up period was longer in the patients studied by Slanina el al.…”

Section: Radiation-indirced Gonadal Damugementioning

confidence: 99%

Disorders of the Endocrine System Due to Radiation and Cytotoxic Chemotherapy

Shalet

1983

Clinical Endocrinology

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Long-term side effects in irradiated patients with Hodgkin's disease

Cited by 106 publications

References 20 publications

Effect of Irradiation Treatment on Gonadal Function in Men Treated for Germ Cell Cancer

Effect of Irradiation Treatment on Gonadal Function in Men Treated for Germ Cell Cancer

Effect of Radiation on the Human Reproductive System

Disorders of the Endocrine System Due to Radiation and Cytotoxic Chemotherapy

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