Resilient denture liners (RDLs) change their hardness in a short time. Hence, their usefulness is limited to the short term only. Therefore, this laboratory study investigated the influence of graphene oxide (GO) nanosheets incorporation on the longevity of a commercially available RDL material. An autopolymerizing acrylic-based RDL was selected for this purpose. The control group (G 0 ) was prepared as such according to the manufacturer's instructions.However, for the G 1 group, 0.1 wt/wt% of GO nanosheet was incorporated in powder of RDL. Similarly, G 2 group and G 3 group were the composites of 0.3 and 0.6 wt/wt% of the GO-resin matrix. A total of 60 disk-shaped samples were prepared, having three subgroups with 15 disks each (n = 15). Surface roughness, water contact angle, Shore A hardness, water sorption, and solubility parameters were evaluated using a two-way analysis of variance (p < .05). GO nanosheets facilitated in reducing the hardness of RDL without affecting the surface roughness and wettability properties. Additionally, statistically reduced water solubility and sorption values were observed in G 3 group, that is, 0.69 ± 0.25% and 0.93 ± 0.18%, respectively, compared to 1.17 ± 0.13% and 1.41 ± 0.18%, respectively, of the control group at the end of 14-day water immersion. The incorporation of GO nanosheets seems a viable option for the enhanced physical properties and clinical life of RDLs.