In ambulatory ECG records, ischemia is manifested by transient ST segment episodes which may or may not be accompanied by increase in heart rate. There are also transient heart-rate related non-ischemic ST segment episodes present which are caused by change in heart rate. The goal of this work was to classify between these two types of ST episodes. The selected features to classify the ST episodes were changes of heart rate, changes of time domain morphologic parameters of the ST segment and changes of the Legendre orthonormal polynomial coefficients of the ST segment, all obtained on 20-second intervals at the beginning and at the extrema of each ST episode. The obtained sensitivity in classifying ischemic versus heart-rate related ST episodes using the LTST DB was 77.9%, while specificity was 73.9%.
IntroductionDuring ischemia, an imbalance occurs due to increased myocardial oxygen demand (demand ischemia, heart rate increase typically precedes ischemia), or due to decreased oxygen supply (supply ischemia, heart rate increase typically follows ischemia) what can lead to injury or death of heart tissue. Early markers of ischemia are transient ST segment deviation and transient ST segment morphology change, and can be detected in 24-hour ambulatory ECG records. There can also be transient non-ischemic ST segment morphology-change episodes which are not caused by an obstruction of the blood flow to the heart, but are caused by simultaneous change in heart rate. These transient non-ischemic heart-rate related ST segment episodes complicate automatic detection of true ischemia. The goal of this work was to automatically distinguish between transient ischemic and heart-rate related ST segment episodes.
Methods
The Long-Term ST DatabaseThe Long-Term ST Database (LTST DB) [1] contains 86 2-or 3-lead 24-hour ambulatory ECG records, sampled at 250 samples s −1 per channel, and is intended for development and testing of automatic ischemia detectors. The records were collected during routine clinical practice to model significant number of real-world clinical conditions. During development of the LTST DB, a considerable preprocessing phase took place in order to derive a number of time series of diagnostic and morphologic parameters. The preprocessing phase included: ARISTO-TLE's [2] analysis yielding stable QRS complex fiducial points (FP), removal of noise, derivation of the instantaneous heart rate, automatic search for the isoelectric level, measurement of the ST segment level, derivation of the Karhunen-Loève Transform (KLT) based ST segment and QRS complex morphology feature vectors, removal of abnormal beats and their neighbors, and removal of noisy beats. Then the positions of the isoelectric level and J point were set manually by human expert annotators using time averaged heart beats computed over 16-second intervals surrounding each normal and non-noisy heart beat which passed the preprocessing phase. These positions were then used to derive the ST segment level functions, stlev(i, j), where i denotes t...