Long-term stability of a three-dimensional dose verification system

Sasaki, Motoharu; Ikushima, Hitoshi; Sugimoto, Wataru; Kitagawa, Kenta

doi:10.1007/s12194-020-00554-7

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…In radiotherapy, dosage verification can effectively reduce the number of errors caused by the planning software [3], hence decreasing the occurrence of radiation sickness. Dose verification in clinical radiotherapy usually includes point dose verification [4][5][6], surface dose verification [7,8], and three-dimensional dose verification [9]. In these methods, only three-dimensional dose verification can accurately reflect the stereoscopic distribution of absorbed doses in the target tissue during radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Gold-Nanoparticle-Enhanced Radio-Fluorogenic Hydrogel Sensor for Low Radiation Doses in Clinical Radiotherapy

et al. 2022

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Radio-fluorogenic hydrogel dosimeters are urgently needed in radiotherapy for 3D dose verification. However, few hydrogel sensors have been reported at low absorbed doses under 2 Gy which meets the requirements of clinical practice. Here, we report a new type of gold-nanoparticle-enhanced radio-fluorogenic agarose hydrogel with coumarin as the dose-responsive material. An optimal composition of 3 wt% of agarose, 0.5 mM of gold nanoparticles, and 0.1 mM coumarin was selected. The addition of gold nanoparticles enhanced the hydroxyl radicals generated from the radiolysis of water, which can react with coumarin and generate fluorescent 7-hydroxy-coumarin and, eventually, achieve low-dose verification of 0–2.4 Gy with a high linear correlation coefficient. These findings provide an effective method for 3D dose verification, and will inspire the development of other radio-fluorogenic sensing hydrogels as well.

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Section: Introductionmentioning

confidence: 99%

Gold-Nanoparticle-Enhanced Radio-Fluorogenic Hydrogel Sensor for Low Radiation Doses in Clinical Radiotherapy

et al. 2022

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Simplification of head and neck volumetric modulated arc therapy patient-specific quality assurance, using a Delta4 PT

Sasaki

Sugimoto

Ikushima

2020

Reports of Practical Oncology & Radiotherapy

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A review of validated techniques and tools for tumor intensity-modulated radiation therapy

Yao,

Chuan

2024

Digital Medicine

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Intensity-modulated radiation therapy (IMRT) is an advanced tumor treatment technique that enables precise three-dimensional dose distribution. However, factors such as field design, data algorithms, and machine errors may lead to deviations between the actual dose and the planned dose, potentially resulting in irradiation errors. Common dose verification methods include point dose verification, two-dimensional dose verification, and three-dimensional dose verification. This paper reviews various verification methods and focuses on the errors and limitations of each method to improve the safety and effectiveness of IMRT treatment.

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Long-term stability of a three-dimensional dose verification system

Cited by 3 publications

References 6 publications

Gold-Nanoparticle-Enhanced Radio-Fluorogenic Hydrogel Sensor for Low Radiation Doses in Clinical Radiotherapy

Gold-Nanoparticle-Enhanced Radio-Fluorogenic Hydrogel Sensor for Low Radiation Doses in Clinical Radiotherapy

Simplification of head and neck volumetric modulated arc therapy patient-specific quality assurance, using a Delta4 PT

A review of validated techniques and tools for tumor intensity-modulated radiation therapy

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