Long‐Term Stability of Contour Augmentation in the Esthetic Zone: Histologic and Histomorphometric Evaluation of 12 Human Biopsies 14 to 80 Months After Augmentation

Jensen, Simon Storgård; Bosshardt, Dieter D.; Gruber, Reinhard; Buser, Daniel

doi:10.1902/jop.2014.140182

Cited by 75 publications

(87 citation statements)

References 36 publications

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“…When compared to no graft, the use of both grafts resulted in significantly higher implant survival rates. In various studies, the bone substitute was found to promote bone regeneration and to allow for long-term stability of the augmented volume [3, 5–8, 31–33]. A recent meta-analysis compared Geistlich Bio-Oss and autogenous bone [24]: For maxillary sinus floor augmentation, a mean implant survival rate of 98.6 ± 2.6% was found for bone substitute, 88.6 ± 4.1% for autogenous bone + bone substitute and 97.4 ± 2.2% for autogenous bone alone.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective analysis of 10,000 implants from insertion up to 20 years—analysis of implantations using augmentative procedures

Knöfler¹,

Barth²,

Graul³

et al. 2016

Int J Implant Dent

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BackgroundA sufficient amount of bone is essential to ensure long-term stability of dental implants. To support the bone regeneration process, different techniques and materials are available. It has been questioned whether these techniques and materials may compromise implant survival compared to pristine bone. To properly answer this question, long-term stability up to 20.2 years after insertion of implants placed in augmented or non-augmented sites was retrospectively analysed.MethodsRetrospective analysis included 10,158 implants from 3095 patients in three private practices who underwent implant therapy with or without bone augmentation procedures. Different graft materials and membranes were used for augmentation. If necessary, the graft was stabilised using a titanium mesh. Implant survival was evaluated analysing explantation rates and Kaplan-Meier survival curves in augmented or non-augmented sites. In additional subgroup analyses, augmentation procedures, graft materials and membranes were compared applying descriptive statistics.ResultsThe observation period varied from the day of implantation up to 20.2 years after implant insertion. The overall implant survival was 95.5% (augmented sites 96.33%; native sites 94.27%). Comparison of Kaplan-Meier survival curves revealed significantly better survival of implants in augmented sites (p = 0.0025). When comparing different augmentation procedures, the best results were found for bone condensing followed by lateral augmentation. Graft materials were used in 58.2%, membranes in 36.6% of all implant sites. The most often used graft materials were a deproteinized bovine bone mineral (53.0%) and autogenous bone particles (32.5%). Both provided the best results and showed a significantly better implant survival compared to no graft material using the Kaplan-Meier method (p = 0.0104 and p < 0.0001). A native collagen membrane was used most often (74.0% of the membrane sites) and provided the best results regarding implant survival in the log-rank test.ConclusionsThe retrospective analysis shows that implants inserted in augmented or native bone demonstrate similar implant survival under the conditions of private practice compared to prospective studies. To establish a broad base of support, further well-designed clinical trials are necessary.

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Section: Discussionmentioning

confidence: 99%

“…Among bone substitutes, deproteinized bovine bone mineral has proven effectiveness in various indications as shown in clinical studies [3–7]. The long-term stability of the augmented volume found with this material is probably due to its slow resorption rate [8]. …”

Section: Introductionmentioning

confidence: 99%

Retrospective analysis of 10,000 implants from insertion up to 20 years—analysis of implantations using augmentative procedures

Knöfler¹,

Barth²,

Graul³

et al. 2016

Int J Implant Dent

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“…Xenografts have been characterized as one of the most widely used bone grafting materials over the past 2 decades [6][7][8]. They are capable of supporting tissue ingrowth and favor long term stability of bone grafting materials.…”

Section: Introductionmentioning

confidence: 99%

Novel Natural Bovine Bone Graft with Integrated Atelo-Collagen Type I: Atelocollagen Bovine Bone Mineral (ABBM) Characterization In-vivo

Raouf¹,

Zhang²,

Caballé‐Serrano³

et al. 2017

Periodon Prosthodon

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Bone grafting materials are routinely utilized in the fields of dental and orthopedic medicine to augment lost or missing bone. While autogenous bone has been considered the gold standard for many years, a variety of alternatives have been proposed including allografts, xenografts and alloplasts to prevent the additional morbidity and limited supply for autografts. Xenografts have frequently been utilized in many countries due to their supporting osteoconductive potential as well as that in many countries, allografts are not permitted.While typically all collagen and growth factors are removed during the processing of xenografts, recently the development of a natural bone mineral containing atelocollagen type I have been proposed utilizing atelopeptidation and lyophilization technologies modifying the collagen components of bone material within bone structure to non-immunogenic atelocollagen. This relatively novel processing technique does not use heat (thermal) processing when manufacturing which has been shown to negatively impact the natural crystalline micro-structure of hydroxyapatite, causing ceramization and destroying collagen components.The lyophilization technique, involves the evaporation of water contained in a product by sublimation -a previously frozen material is placed in a vacuum, which turns the ice directly to vapor. This new processing technique for xenografts has been shown to preserve lyophilized collagen with lower humidity making the bone matrix hydrophilic. These bone grafts contain roughly 2% moisture, 65-75% hydroxyapatite, 25-35% atelo-collagen content and up to 0.1% non-collagenous proteins. Here we investigated these novel atelo-collagenized bovine bone mineral (ABBM) bone grafts using scanning electron microscopy (SEM) and evaluated their bone regenerative potential in a rat femur animal model.

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“…Advantages of locally harvesting autogenous bone chips for guided bone regeneration procedures include (1) the use of an autogenous source with no issues of immune system compatibility, (2) a bone graft containing living progenitor cells within the scaffold capable of differentiating into and/or stimulating bone forming osteoblasts, as well as (3) the ability for the graft to release a wide array of osteoinductive growth factors capable of speeding new bone formation [2]. For these reasons, favorable longterm results in implant dentistry requiring bone augmentation procedures are routinely augmented using autogenous bone chips adjacent to implant surfaces to favor faster implant osseointegration [3,4].…”

Section: Introductionmentioning

confidence: 99%

Pre-coating deproteinized bovine bone mineral (DBBM) with bone-conditioned medium (BCM) improves osteoblast migration, adhesion, and differentiation in vitro

et al. 2016

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Long‐Term Stability of Contour Augmentation in the Esthetic Zone: Histologic and Histomorphometric Evaluation of 12 Human Biopsies 14 to 80 Months After Augmentation

Cited by 75 publications

References 36 publications

Retrospective analysis of 10,000 implants from insertion up to 20 years—analysis of implantations using augmentative procedures

Retrospective analysis of 10,000 implants from insertion up to 20 years—analysis of implantations using augmentative procedures

Novel Natural Bovine Bone Graft with Integrated Atelo-Collagen Type I: Atelocollagen Bovine Bone Mineral (ABBM) Characterization In-vivo

Pre-coating deproteinized bovine bone mineral (DBBM) with bone-conditioned medium (BCM) improves osteoblast migration, adhesion, and differentiation in vitro

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