Long‐Term Statin Therapy Affects the Severity of Chronic Gastritis

Abstract

Long-standing statin therapy may reduce the severity of chronic gastritis. Mild increased CRP levels in absence of obvious source can predict the severity of chronic gastritis. Further researches are needed to assess the effect of statin in chronic gastritis.

The impact of prior long-term versus short-term statin use on the mortality of bacteraemic patients

“…Although the therapeutically beneficial effects of statins in these diseases are generally attributed to their cholesterol-lowering action, the results from an increasing number of in vitro and in vivo studies indicate that statins also have anti-inflammatory effects that are independent of their hypocholesterolemic activity [2,3]. Statins have also been reported to have immunomodulatory, antioxidative, and antithrombotic actions [4][5][6].…”

Statin Decreases Helicobacter pylori Burden in Macrophages by Promoting Autophagy

“…Depletion of cellular cholesterol not only attenuates H. pylori -induced pathogenesis (Hutton et al, 2010; Lai et al, 2011) but also promotes autophagy (Cheng et al, 2006), which has been shown to contribute to immune defense against invading pathogens (Levine et al, 2011; Deretic et al, 2013; Lai et al, 2015). Statins, inhibitors of HMG-CoA reductase that are widely prescribed for lowering serum cholesterol, have also been employed to reduce the risk of certain bacterial infections (Chow et al, 2010; Nseir et al, 2010; Boyd et al, 2012; Motzkus-Feagans et al, 2012). The in vitro and ex vivo approaches utilized in this study provided evidence that statin treatment results in reduced bacterial burden in macrophages, and consequently attenuation of H. pylori pathogenesis, via activation of autophagy.…”

Involvement of Cholesterol in Campylobacter jejuni Cytolethal Distending Toxin-Induced Pathogenesis

“…Previous studies demonstrated that statins are used to reduce the risk of some bacterial infections, including Chlamydia pneumonia [51], Clostridium difficile [52], H. pylori [53], Streptococcus pneumonia [54] and Staphylococcus aureus [55]. These findings shed light on the novel approach that inhibition of cellular cholesterol may be useful to inhibit bacteria-induced pathogenesis.…”