Long-term structural remodeling in Aplysia sensory neurons requires de novo protein synthesis during a critical time period

O'Leary, Fidelma A.; Byrne, John H.; Cleary, Len

doi:10.1523/jneurosci.15-05-03519.1995

Cited by 38 publications

(28 citation statements)

References 56 publications

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“…Whereas this idea at present is speculative, there is already some evidence in Aplysia that the long-term domain of memory for sensitization may be composed of separable phases. For example, O'Leary et al (1995) found that the time window during which protein synthesis was required for long-term (24 h) structural remodeling of Aplysia SNs was extended several hours beyond that required for LTF (24 h) at SN-MN synapses described by Montarolo and colleagues (1986). These results raised the possibility that at least one component of LTF (and LTM) may be independent of structural plasticity.…”

Section: Multiphasic Organization Of Memory Processingmentioning

confidence: 96%

Interaction between Amount and Pattern of Training in the Induction of Intermediate- and Long-Term Memory for Sensitization in Aplysia

Sutton¹,

Ide²,

Masters³

et al. 2002

Learn. Mem.

119

118

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In Aplysia, three distinct phases of memory for sensitization can be dissociated based on their temporal and molecular features. A single training trial induces short-term memory (STM, lasting <30 min), whereas five trials delivered at 15-min intervals induces both intermediate-term memory (ITM, lasting >90 min) and long-term memory (LTM, lasting >24 h). Here, we explore the interaction of amount and pattern of training in establishing ITM and LTM by examining memory for sensitization after different numbers of trials (each trial = one tail shock) and different patterns of training (massed vs. spaced). Under spaced training patterns, two trials produced STM exclusively, whereas four or five trials each produced both ITM and LTM. Three spaced trials failed to induce LTM but did produce an early decaying form of ITM (E-ITM) that was significantly shorter and weaker in magnitude than the late-decaying ITM (L-ITM) observed after four to five trials. In addition, E-ITM was induced after three trials with both massed and spaced patterns of training. However, L-ITM and LTM after four to five trials require spaced training: Four or five massed trials failed to induce LTM and produced only E-ITM. Collectively, our results indicate that in addition to three identified phases of memory for sensitization-STM, ITM, and LTM-a unique temporal profile of memory, E-ITM, is revealed by varying either the amount or pattern of training.

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Section: Multiphasic Organization Of Memory Processingmentioning

confidence: 96%

Interaction between Amount and Pattern of Training in the Induction of Intermediate- and Long-Term Memory for Sensitization in Aplysia

Sutton¹,

Ide²,

Masters³

et al. 2002

Learn. Mem.

119

118

View full text Add to dashboard Cite

show abstract

“…However, no attempt has yet been made to integrate experimental data concerning the kinetics of activation of these transcription factors into a model. CREB can bind to Ca 2+ /cAMP-responsive elements (CREs) to induce the transcription of genes crucial for neuronal plasticity (Bartsch et al, 1995;O'Leary et al, 1995;Yin and Tully, 1996;Femino et al, 1998). Proteins related to CREB, such as CREB2, are transcriptional repressors that bind to the same CRE sequence as CREB (Sassone-Corsi, 1995).…”

Section: 1mentioning

confidence: 99%

Modeling Transcriptional Control in Gene Networks—Methods, Recent Results, and Future Directions

Smolen

Baxter

Byrne

2000

Bulletin of Mathematical Biology

280

161

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Mathematical models are useful for providing a framework for integrating data and gaining insights into the static and dynamic behavior of complex biological systems such as networks of interacting genes. We review the dynamic behaviors expected from model gene networks incorporating common biochemical motifs, and we compare current methods for modeling genetic networks. A common modeling technique, based on simply modeling genes as ON-OFF switches, is readily implemented and allows rapid numerical simulations. However, this method may predict dynamic solutions that do not correspond to those seen when systems are modeled with a more detailed method using ordinary differential equations. Until now, the majority of gene network modeling studies have focused on determining the types of dynamics that can be generated by common biochemical motifs such as feedback loops or protein oligomerization. For example, these elements can generate multiple stable states for gene product concentrations, state-dependent responses to stimuli, circadian rhythms and other oscillations, and optimal stimulus frequencies for maximal transcription. In the future, as new experimental techniques increase the ease of characterization of genetic networks, qualitative modeling will need to be supplanted by quantitative models for specific systems.

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“…However, the requirement for gene expression is not limited to the induction phase. The necessity of prolonged transcription and translation persists for at least 7-9 h after induction (Alberini et al, 1994;O'Leary et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

cAMP Response Element-Binding Protein 1 Feedback Loop Is Necessary for Consolidation of Long-Term Synaptic Facilitation inAplysia

Liu¹,

Fioravante²,

Shah³

et al. 2008

J. Neurosci.

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The transcription factor cAMP response element (CRE)-binding protein (CREB) plays an essential role in the induction of many forms of long-term synaptic plasticity. Levels of CREB1, the Aplysia homolog of CREB, show sustained elevations for several hours after the induction of long-term synaptic facilitation (LTF). Furthermore, CREB1 binds to the promoter of its own gene. These results suggest the existence of a CREB1-positive feedback loop that contributes to the consolidation of LTF. In the present study, we provide a detailed, quantitative characterization of the dynamics of CREB1 mRNA and protein as well as CREB1 phosphorylation after LTF induction. Injections of CRE oligonucleotides prevented the increase in CREB1 in response to 5-HT, corroborating the existence of the CREB1 feedback loop. This loop probably sustains CRE-dependent gene transcription, which remains elevated for at least 12 h after LTF induction. LTF is blocked by injection of CREB1 antibody after the induction phase, suggesting that the CREB1-positive feedback is required for consolidation of LTF.

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Long-term structural remodeling in Aplysia sensory neurons requires de novo protein synthesis during a critical time period

Cited by 38 publications

References 56 publications

Interaction between Amount and Pattern of Training in the Induction of Intermediate- and Long-Term Memory for Sensitization in Aplysia

Interaction between Amount and Pattern of Training in the Induction of Intermediate- and Long-Term Memory for Sensitization in Aplysia

Modeling Transcriptional Control in Gene Networks—Methods, Recent Results, and Future Directions

cAMP Response Element-Binding Protein 1 Feedback Loop Is Necessary for Consolidation of Long-Term Synaptic Facilitation inAplysia

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