Long-Term Studies on Regression of Left Ventricular Hypertrophy

Franz, I.-W.; Ketelhut, Reinhard G.; Behr, Ü.; Tönnesmann, U.

doi:10.1007/978-3-642-85498-9_9

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1999

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“…[1][2][3][4] In meta-analyses of prospective trials a significant difference between drug classes in the ability to reduce LV hypertrophy has been shown. 3,4 Angiotensinconverting enzyme (ACE) inhibitors have been shown to reduce LV mass more than beat-blockers and diuretics, with calcium (Ca) channel blockers in between.…”

Section: Introductionmentioning

confidence: 99%

The influence of different antihypertensive drugs on left ventricular hypertrophy in a population sample of elderly men

1999

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Aims and methods: To evaluate if the effects of longterm treatment with different antihypertensive drugs on left ventricular (LV) hypertrophy seen in meta-analysis could also be found in a cross-sectional study of elderly men, we investigated 584 70-year-old men with echocardiography of which 179 were treated for hypertension. Results: Men on antihypertensive treatment showed a significantly higher LV mass than normotensive men (143 ± 29 vs 132 ± 28 g/m 2 , P Ͻ 0.01), but no significant difference in LV mass was seen between men on one antihypertensive drug (n = 129) and those on two drugs (n = 47). Among the men on monotherapy, no differences in LV mass between the subjects who were treated with calcium-antagonists (142 ± 27 g/m 2 , n = 37),

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